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World Journal of Emergency Surgery
Published in: World Journal of Emergency Surgery 1/2019

Open Access 01-12-2019 | Computed Tomography | Research article

Prediction of arterial extravasation in pelvic fracture patients with stable hemodynamics using coagulation biomarkers

Authors: Makoto Aoki, Takayuki Ogura, Shuichi Hagiwara, Mitsunobu Nakamura, Kiyohiro Oshima

Published in: World Journal of Emergency Surgery | Issue 1/2019

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Abstract

Background

Determining the presence of an active arterial hemorrhage in the acute phase is important as a treatment strategy in patients with pelvic fracture. The purpose of this study was to evaluate whether coagulation biomarkers could predict arterial extravasation, especially in pelvic fracture patients with stable hemodynamics.

Methods

We studied patients with a pelvic fracture who had a systolic blood pressure above 90 mmHg and lactate level less than 5.0 mmol/L on hospital arrival. Patients were divided into two groups: those with arterial extravasation on enhanced computed tomography (CT) or angiography (extravasation [+] group) and those without arterial extravasation (extravasation [−] group). Coagulation biomarkers measured on arrival were statistically compared between the two groups. Predictive ability of arterial extravasation using coagulation biomarkers was evaluated by receiver-operating characteristic analyses provided area under the receiver-operating characteristic curves (AUROC) and diagnostic indicators with optimal cutoff point including sensitivity, specificity, positive and negative predictive values, and diagnostic odds ratio (DOR).

Results

Sixty patients were analyzed. Fibrin degradation products (FDP), D-dimer, prothrombin time–international normalized ratio (PT–INR), and the ratio of FDP to fibrinogen were significantly higher in the extravasation (+) group than in the extravasation (−) group (FDP, 242 μg/mL [145–355] vs. 96 μg/mL [58–153]; D-dimer, 81 μg/mL [41–140] vs. 39 μg/mL [21–75]; PT–INR, 1.09 [1.05–1.24] vs. 1.02 [0.98–1.08]; and ratio of FDP to fibrinogen, 1.06 [0.85–2.01] vs. 0.46 [0.25–0.74]). The highest AUROC was with a ratio of FDP to fibrinogen of 0.777 (95% confidence interval, 0.656–0.898), and the highest predictive ability in terms of DOR was with a ratio of FDP to fibrinogen (sensitivity, 0.76; specificity, 0.76; DOR 9.90).

Conclusion

Coagulation biomarker could predict of arterial extravasation in pelvic fracture patients with stable hemodynamics.
Appendix
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Metadata
Title
Prediction of arterial extravasation in pelvic fracture patients with stable hemodynamics using coagulation biomarkers
Authors
Makoto Aoki
Takayuki Ogura
Shuichi Hagiwara
Mitsunobu Nakamura
Kiyohiro Oshima
Publication date
01-12-2019
Publisher
BioMed Central
Published in
World Journal of Emergency Surgery / Issue 1/2019
Electronic ISSN: 1749-7922
DOI
https://doi.org/10.1186/s13017-019-0234-5

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