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Radiation Oncology
Published in: Radiation Oncology 1/2020

01-12-2020 | Metastasis | Research

Missed radiation therapy sessions in first three weeks predict distant metastasis and less favorable outcomes in surgically treated patients with oral cavity squamous cell carcinoma

Authors: Yin-Yin Chiang, Yung-Chih Chou, Kai-Ping Chang, Chun-Ta Liao, Yao-Yu Wu, Wing-Keen Yap, Ping-Ching Pai, Joseph Tung-Chieh Chang, Chien-Yu Lin, Kang-Hsing Fan, Bing-Shen Huang, Tsung-Min Hung, Ngan-Ming Tsang

Published in: Radiation Oncology | Issue 1/2020

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Abstract

Background

We sought to investigate the prognostic impact of missed RT sessions in patients who had undergone surgery for oral cavity squamous cell carcinoma (OCSCC).

Methods

The study sample consisted of 905 patients with surgically treated OCSCC who fulfilled criteria of RT course ≤8 weeks. The study participants were divided into three groups based on the characteristics of missed RT, as follows: 1) early missed RT, 2) late missed RT, and 3) RT as scheduled.

Results

The 5-year overall survival (OS) rates in the early missed RT, late missed RT, and RT as scheduled groups were 53.0, 58.1, and 64.5%, respectively (p = 0.046). In multivariate analysis, early missed RT was independently associated with both OS (hazard ratio (HR) = 1.486; 95% confidence interval (CI): 1.122–1.966; p = 0.006) and the occurrence of distant metastasis (HR = 1.644; 95% CI: 1.047–2.583; p = 0.031).

Conclusion

Early missed RT was independently associated with a higher occurrence of distant metastasis and less favorable OS in patients who had undergone surgery for OCSCC.
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Metadata
Title
Missed radiation therapy sessions in first three weeks predict distant metastasis and less favorable outcomes in surgically treated patients with oral cavity squamous cell carcinoma
Authors
Yin-Yin Chiang
Yung-Chih Chou
Kai-Ping Chang
Chun-Ta Liao
Yao-Yu Wu
Wing-Keen Yap
Ping-Ching Pai
Joseph Tung-Chieh Chang
Chien-Yu Lin
Kang-Hsing Fan
Bing-Shen Huang
Tsung-Min Hung
Ngan-Ming Tsang
Publication date
01-12-2020
Publisher
BioMed Central
Published in
Radiation Oncology / Issue 1/2020
Electronic ISSN: 1748-717X
DOI
https://doi.org/10.1186/s13014-020-01632-1

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