Skip to main content
Top
Published in: Radiation Oncology 1/2019

Open Access 01-12-2019 | Radiotherapy | Case report

Radiotherapy for recurrent central Giant cell granuloma: a case report

Authors: Qi Zhang, Zelai He, Gengming Wang, Hao Jiang

Published in: Radiation Oncology | Issue 1/2019

Login to get access

Abstract

Background

Central giant cell granuloma (CGCG) is a rare, non-neoplastic, benign lesion that exhibits expansive and osteolytic biological behavior. CGCG treatment and management is challenging for clinicians.

Case presentation

This report presents the treatment and management of recurrent, aggressive CGCG after surgical resection. After informed consent was obtained, the patient underwent radiotherapy. The lesion size was reduced significantly, with no evidence of recurrence or malignant transformation.

Conclusions

This treatment experience indicates that radiotherapy can be used as a rescue treatment for complicated CGCG involving vital neurovascular structures of the cranial base.
Literature
1.
go back to reference Reddy V, Saxena S, Aggarwal P, Sharma P, Reddy M. Incidence of central giant cell granuloma of the jaws with clinical and histological confirmation: an archival study in northern India. Br J Oral Maxillofac Surg. 2012;50(7):668–72.CrossRef Reddy V, Saxena S, Aggarwal P, Sharma P, Reddy M. Incidence of central giant cell granuloma of the jaws with clinical and histological confirmation: an archival study in northern India. Br J Oral Maxillofac Surg. 2012;50(7):668–72.CrossRef
2.
go back to reference Rihani J, Kutz JW, Isaacson B. Hearing outcomes after surgical drainage of petrous apex cholesterol granuloma. J Neurol Surg B. 2015;76(03):171–5.CrossRef Rihani J, Kutz JW, Isaacson B. Hearing outcomes after surgical drainage of petrous apex cholesterol granuloma. J Neurol Surg B. 2015;76(03):171–5.CrossRef
3.
go back to reference Katherine T, Grigoris V, George K, Fotis I. Central Giant cell granuloma of the jaws: a clinical study of 17 cases and a review of the literature. Ann Otol Rhinol Laryngol. 2011;120(3):167–74.CrossRef Katherine T, Grigoris V, George K, Fotis I. Central Giant cell granuloma of the jaws: a clinical study of 17 cases and a review of the literature. Ann Otol Rhinol Laryngol. 2011;120(3):167–74.CrossRef
4.
go back to reference Jaffe HL. Giant-cell reparative granuloma, traumatic bone cyst, and fibrous (fibro-osseous) dysplasia of the jawbones. Oral Surg Oral Med Oral Pathol. 1953;6(1):159–75.CrossRef Jaffe HL. Giant-cell reparative granuloma, traumatic bone cyst, and fibrous (fibro-osseous) dysplasia of the jawbones. Oral Surg Oral Med Oral Pathol. 1953;6(1):159–75.CrossRef
5.
go back to reference Murphey MD, Nomikos GC, Flemming DJ, Gannon FH, Temple HT, Kransdorf MJ. From the archives of AFIP. Imaging of giant cell tumor and giant cell reparative granuloma of bone: radiologic-pathologic correlation. Radiographics. 2001;21(5):1283–309.CrossRef Murphey MD, Nomikos GC, Flemming DJ, Gannon FH, Temple HT, Kransdorf MJ. From the archives of AFIP. Imaging of giant cell tumor and giant cell reparative granuloma of bone: radiologic-pathologic correlation. Radiographics. 2001;21(5):1283–309.CrossRef
6.
go back to reference Csillag A, Pharoah M, Gullane P, Mancer K, Disney TV. A central giant cell granuloma influenced by pregnancy. Dentomaxillofac Radiol. 1997;26(6):357–60.CrossRef Csillag A, Pharoah M, Gullane P, Mancer K, Disney TV. A central giant cell granuloma influenced by pregnancy. Dentomaxillofac Radiol. 1997;26(6):357–60.CrossRef
7.
go back to reference Dos Santos LA, Campos PS, Laranjeira AL, Bonan PR, Martelli H Jr, Cardoso SV. Effectiveness of computed tomography to evaluate central giant cell lesion. Dentomaxillofac Radiol. 2007;36(8):522–5.CrossRef Dos Santos LA, Campos PS, Laranjeira AL, Bonan PR, Martelli H Jr, Cardoso SV. Effectiveness of computed tomography to evaluate central giant cell lesion. Dentomaxillofac Radiol. 2007;36(8):522–5.CrossRef
8.
go back to reference Tarsitano A, Del Corso G, Pizzigallo A, Marchetti C. Aggressive central Giant cell granuloma of the mandible treated with conservative surgical enucleation and interferon-alpha-2a: complete remission with long-term follow-up. J Oral Maxillofac Surg. 2015;73(11):2149–54.CrossRef Tarsitano A, Del Corso G, Pizzigallo A, Marchetti C. Aggressive central Giant cell granuloma of the mandible treated with conservative surgical enucleation and interferon-alpha-2a: complete remission with long-term follow-up. J Oral Maxillofac Surg. 2015;73(11):2149–54.CrossRef
9.
go back to reference Bird P, Souter M. Giant cell reparative granuloma of the temporal bone treated with calcitonin--10 years on. Otol Neurotol. 2015;36(7):1296.CrossRef Bird P, Souter M. Giant cell reparative granuloma of the temporal bone treated with calcitonin--10 years on. Otol Neurotol. 2015;36(7):1296.CrossRef
10.
go back to reference Tabrizi R, Fardisi S, Zamiri B, Amanpour S, Karagah T. Can calcitonin nasal spray reduce the risk of recurrence of central giant cell granuloma of the jaws? A double-blind clinical trial. Int J Oral Maxillofac Surg. 2016;45(6):756–9.CrossRef Tabrizi R, Fardisi S, Zamiri B, Amanpour S, Karagah T. Can calcitonin nasal spray reduce the risk of recurrence of central giant cell granuloma of the jaws? A double-blind clinical trial. Int J Oral Maxillofac Surg. 2016;45(6):756–9.CrossRef
11.
go back to reference Bredell M, Rordorf T, Kroiss S, Rucker M, Zweifel DF, Rostetter C. Denosumab as a treatment alternative for central Giant cell granuloma: a long-term retrospective cohort study. J Oral Maxillofac Surg. 2018;76(4):775–84.CrossRef Bredell M, Rordorf T, Kroiss S, Rucker M, Zweifel DF, Rostetter C. Denosumab as a treatment alternative for central Giant cell granuloma: a long-term retrospective cohort study. J Oral Maxillofac Surg. 2018;76(4):775–84.CrossRef
12.
go back to reference Schreuder WH, van den Berg H, Westermann AM, Peacock ZS, de Lange J. Pharmacological and surgical therapy for the central giant cell granuloma: a long-term retrospective cohort study. J Craniomaxillofac Surg. 2017;45(2):232–43.CrossRef Schreuder WH, van den Berg H, Westermann AM, Peacock ZS, de Lange J. Pharmacological and surgical therapy for the central giant cell granuloma: a long-term retrospective cohort study. J Craniomaxillofac Surg. 2017;45(2):232–43.CrossRef
13.
go back to reference Chien MC, Mascarenhas L, Hammoudeh JA, Venkatramani R. Zoledronic acid for the treatment of children with refractory central Giant cell granuloma. J Pediatr Hematol Oncol. 2015;37(6):e399–401.CrossRef Chien MC, Mascarenhas L, Hammoudeh JA, Venkatramani R. Zoledronic acid for the treatment of children with refractory central Giant cell granuloma. J Pediatr Hematol Oncol. 2015;37(6):e399–401.CrossRef
14.
go back to reference Findlay JM, Chiasson D, Hudson AR, Chui M. Giant-cell tumor of the middle cranial fossa. Case report. J Neurosurg. 1987;66(6):924–8.CrossRef Findlay JM, Chiasson D, Hudson AR, Chui M. Giant-cell tumor of the middle cranial fossa. Case report. J Neurosurg. 1987;66(6):924–8.CrossRef
15.
go back to reference D'Ambrosio AL, Williams SC, Lignelli A, Salchow DJ, Spicer G, Libien J, Chin SS, Liebsch NJ, Kazim M, Bruce JN, et al. Clinicopathological review: giant cell reparative granuloma of the orbit. Neurosurgery. 2005;57(4):773–8 discussion 773-778.CrossRef D'Ambrosio AL, Williams SC, Lignelli A, Salchow DJ, Spicer G, Libien J, Chin SS, Liebsch NJ, Kazim M, Bruce JN, et al. Clinicopathological review: giant cell reparative granuloma of the orbit. Neurosurgery. 2005;57(4):773–8 discussion 773-778.CrossRef
16.
go back to reference Wiatrak BJ, Gluckman JL, Fabian RL, Wesseler TA. Giant cell reparative granuloma of the ethmoid sinus. Otolaryngol Head Neck Surg. 1987;97(5):504–9.CrossRef Wiatrak BJ, Gluckman JL, Fabian RL, Wesseler TA. Giant cell reparative granuloma of the ethmoid sinus. Otolaryngol Head Neck Surg. 1987;97(5):504–9.CrossRef
Metadata
Title
Radiotherapy for recurrent central Giant cell granuloma: a case report
Authors
Qi Zhang
Zelai He
Gengming Wang
Hao Jiang
Publication date
01-12-2019
Publisher
BioMed Central
Published in
Radiation Oncology / Issue 1/2019
Electronic ISSN: 1748-717X
DOI
https://doi.org/10.1186/s13014-019-1336-7

Other articles of this Issue 1/2019

Radiation Oncology 1/2019 Go to the issue