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Radiation Oncology
Published in: Radiation Oncology 1/2017

Open Access 01-12-2017 | Research

Dose tracking assessment for image-guided radiotherapy of the prostate bed and the impact on clinical workflow

Authors: Lucia Clara Orlandini, Marianna Coppola, Christian Fulcheri, Luna Cernusco, Pei Wang, Luca Cionini

Published in: Radiation Oncology | Issue 1/2017

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Abstract

Background

The cumulative dose was compared with the planned dose among fourteen patients undergoing image-guided, intensity-modulated radiotherapy of the prostate bed. Moreover, we investigated the feasibility of adding dose tracking to the routine workflow for radiotherapy.

Methods

Daily cone beam computed tomography was conducted for image-guided radiotherapy, and weekly cumulative delivered doses were calculated for dose tracking. Deformable image registration was applied to map weekly dose distributions to the original treatment plan and to create a cumulative dose distribution. The dose–volume histogram (DVH) cut-off points for the rectum and bladder and the planning target volume (PTV), were used to compare the planned and cumulative delivered doses. The additional time required by the departmental staff to complete these duties was recorded.

Results

The PTV coverage of the delivered treatment did not satisfy the expected goal for three patients (V98% >98%). In another three patients, the DVH cut-off point for the bladder was higher than the limits, while for the rectum, treatment was as expected in all cases (two patients failed both their bladder constraints and the PTV coverage). Overall, four patients did not satisfy one or more criteria at the end of their treatment.

Conclusions

A well-defined strategy for dose tracking assessment is feasible, would have minimal impact on the workload of a radiotherapy department, and may offer objective information to support radiation oncologists in making decisions about adaptive procedures.
Literature
1.
Bauman G, Rumble RB, Chen J, Loblaw A, Warde P. Intensity-modulated radiotherapy in the treatment of prostate cancer. Clin Oncol. 2012;24(7):461–73.CrossRef
2.
Kame’enui EJ, Simmons DC. Knowledge-based IMRT treatment planning for prostate cancer. Med Phys. 2011;38(5):2515–22.CrossRef
3.
Veldeman L, Madani I, Hulstaert F, De MG, Mareel M, De NW. Evidence behind use of intensity-modulated radiotherapy: a systematic review of comparative clinical studies. Lancet Oncol. 2008;9(4):367.CrossRefPubMed
4.
Frank SJ, Dong L, Kudchadker RJ, De CR, Lee AK, Cheung R, et al. Quantification of prostate and seminal vesicle interfraction variation during IMRT. Int J Radiat Oncol Biol Phys. 2008;71(3):813.CrossRefPubMed
5.
Hoogeman MS, Van HM, De BJ, Lebesque JV. Strategies to reduce the systematic error due to tumor and rectum motion in radiotherapy of prostate cancer. Radiother Oncol. 2005;74(2):177–85.CrossRefPubMed
6.
Kupelian PA, Langen KM, Willoughby TR, Wagner TH, Zeidan OA, Meeks SL. Daily variations in the position of the prostate bed in patients with prostate cancer receiving postoperative external beam radiation therapy. Int J Radiat Oncol Biol Phys. 2006;66(2):593–6.CrossRefPubMed
7.
Reddy NM, Nori D, Chang H, Lange CS, Ravi A. Prostate and seminal vesicle volume based consideration of prostate cancer patients for treatment with 3D-conformal or intensity-modulated radiation therapy. Med Phys. 2010;37(7):3791–801.CrossRefPubMed
8.
Bylund KC, Bayouth JE, Smith MC, Hass AC, Bhatia SK, Buatti JM. Analysis of interfraction prostate motion using megavoltage cone beam computed tomography. Int J Radiat Oncol Biol Phys. 2008;72(3):949–56.CrossRefPubMed
9.
Kupelian P, Meyer JL. Image-guided, adaptive radiotherapy of prostate cancer: toward New standards of radiotherapy practice. Front Radiat Ther Oncol. 2011;43:344–68.CrossRefPubMed
10.
11.
Han Liu QW. Evaluations of an adaptive planning technique incorporating dose feedback in image-guided radiotherapy of prostate cancer. Med Phys. 2011;38(12):6362–70.CrossRefPubMedPubMedCentral
12.
Nuver TT, Hoogeman MS, Remeijer P, Van HM, Lebesque JV. An adaptive off-line procedure for radiotherapy of prostate cancer. Int J Radiat Oncol Biol Phys. 2007;67(5):1559–67.CrossRefPubMed
13.
Wu Q, Liang J, Yan D. Application of dose compensation in image-guided radiotherapy of prostate cancer. Phys Med Biol. 2006;51(6):1405–19.CrossRefPubMed
14.
Michalski JM, Lawton C, El NI, Ritter M, O’Meara E, Seider MJ, et al. Development of RTOG consensus guidelines for the definition of the clinical target volume for postoperative conformal radiation therapy for prostate cancer. Int J Radiat Oncol Biol Phys. 2010;76(2):361–8.CrossRefPubMed
15.
Johnson M. Patient dose and image quality from mega-voltage cone beam computed tomography imaging. Med Phys. 2007;34(2):499–506.CrossRefPubMed
16.
Morin O, Gillis A, Descovich M, Chen J, Aubin M, Aubry JF, et al. Patient dose considerations for routine megavoltage cone-beam CT imaging. Med Phys. 2007;34(5):1819–27.CrossRefPubMed
17.
Miften M, Gayou O, Reitz B, Fuhrer R, Leicher B, Parda DS. IMRT planning and delivery incorporating daily dose from mega‐voltage cone‐beam computed tomography imaging. Med Phys. 2007;34(10):3760–7.CrossRefPubMed
18.
Hodapp N. The ICRU Report 83: prescribing, recording and reporting photon-beam intensity-modulated radiation therapy (IMRT). Strahlenther Onkol. 2012;188(1):97.CrossRefPubMed
19.
Jackson A, Marks LB, Bentzen SM, Eisbruch A, Yorke ED, Ten Haken RK, et al. The lessons of QUANTEC: recommendations for reporting and gathering data on dose-volume dependencies of treatment outcome. Int J Radiat Oncol Biol Phys. 2010;76(3):155–60.CrossRef
20.
Lee WR, Dignam JJ, Amin M, Bruner D, Low D, Swanson GP, et al. NRG Oncology RTOG 0415: A randomized phase III non-inferiority study comparing two fractionation schedules in patients with low-risk prostate cancer. Int J Radiat Oncol Biol Phys. 2016;94(1):3–4.CrossRef
21.
Morin O, Gillis A, Chen J, Aubin M, Bucci MK, Iii MR, et al. Megavoltage cone-beam CT: System description and clinical applications. Med Dosim. 2006;31(1):51–61.CrossRefPubMed
22.
García-Mollá R, De M-BN, Bonaque J, Vidueira L, López-Tarjuelo J, Perez-Calatayud J. Validation of a deformable image registration produced by a commercial treatment planning system in head and neck. Phys Med. 2015;31(3):219–23.CrossRefPubMed
23.
Hardcastle N, Elmpt WV, Ruysscher DD, Bzdusek K, Tomé WA. Accuracy of deformable image registration for contour propagation in adaptive lung radiotherapy. Radiat Oncol. 2013;8(1):1–8.CrossRef
24.
Sarrut D. Deformable registration for image-guided radiation therapy. Zeitschrift Für Medizinische Physik. 2006;16(4):285.CrossRefPubMed
25.
Schreibmann E, Pantalone P, Waller A, Fox T. A measure to evaluate deformable registration fields in clinical settings. J Appl Clin Med Phys. 2012;13(5):3829.CrossRefPubMed
26.
Mzenda B, Mugabe KV, Sims R, Godwin G, Loria D. Modeling and dosimetric performance evaluation of the RayStation treatment planning system. J Appl Clin Med Phys. 2014;15(5):29–46.CrossRef
27.
Weistrand O, Svensson S. The ANACONDA algorithm for deformable image registration in radiotherapy. Med Phys. 2015;42:40.CrossRefPubMed
28.
Sumida I. Megavoltage cone beam computed tomography dose and the necessity of reoptimization for imaging dose-integrated intensity-modulated radiotherapy for prostate cancer. Int J Radiat Oncol Biol Phys. 2012;82(5):1715.CrossRefPubMed
29.
Morgan-Fletcher SL. Prescribing, recording and reporting photon beam therapy (supplement to ICRU report 50), ICRU report 62. ICRU, pp. ix + 52, 1999 (ICRU Bethesda, MD). Br J Radiol. 2001;74(879):294.CrossRef
30.
Teh BS, Mcgary JE, Dong L, Mai WY, Carpenter LS, Lu HH, et al. The use of rectal balloon during the delivery of intensity modulated radiotherapy (IMRT) for prostate cancer: more than just a prostate gland immobilization device? Cancer J. 2002;8(6):476–83.CrossRefPubMed
31.
Qin A, Sun Y, Liang J, Yan D. Evaluation of online/offline image guidance/adaptation approaches for prostate cancer radiation therapy. Int J Radiat Oncol Biol Phys. 2015;91(5):1026.CrossRefPubMed
32.
Stanley K, Eade T, Kneebone A, Booth JT. Investigation of an adaptive treatment regime for prostate radiation therapy. Pract Radiat Oncol. 2014;5(1):e23–e9.CrossRefPubMed
Metadata
Title
Dose tracking assessment for image-guided radiotherapy of the prostate bed and the impact on clinical workflow
Authors
Lucia Clara Orlandini
Marianna Coppola
Christian Fulcheri
Luna Cernusco
Pei Wang
Luca Cionini
Publication date
01-12-2017
Publisher
BioMed Central
Published in
Radiation Oncology / Issue 1/2017
Electronic ISSN: 1748-717X
DOI
https://doi.org/10.1186/s13014-017-0815-y

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