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Radiation Oncology

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Open Access 01-12-2013 | Research

Accuracy of deformable image registration for contour propagation in adaptive lung radiotherapy

Authors: Nicholas Hardcastle, Wouter van Elmpt, Dirk De Ruysscher, Karl Bzdusek, Wolfgang A Tomé

Published in: Radiation Oncology | Issue 1/2013

Abstract

Background

Deformable image registration (DIR) is an attractive method for automatic propagation of regions of interest (ROIs) in adaptive lung radiotherapy. This study investigates DIR for automatic contour propagation in adaptive Non Small Cell Lung Carcinoma patients.

Methods

Pre and mid-treatment fan beam 4D-kVCT scans were taken for 17 NSCLC patients. Gross tumour volumes (GTV), nodal-GTVs, lungs, esophagus and spinal cord were delineated on all kVCT scans. ROIs were propagated from pre- to mid-treatment images using three DIR algorithms. DIR-propagated ROIs were compared with physician-drawn ROIs on the mid-treatment scan using the Dice score and the mean slicewise Hausdorff distance to agreement (MSHD). A physician scored the DIR-propagated ROIs based on clinical utility.

Results

Good agreement between the DIR-propagated and physician drawn ROIs was observed for the lungs and spinal cord. Agreement was not as good for the nodal-GTVs and esophagus, due to poor soft-tissue contrast surrounding these structures. 96% of OARs and 85% of target volumes were scored as requiring no or minor adjustments.

Conclusions

DIR has been shown to be a clinically useful method for automatic contour propagation in adaptive radiotherapy however thorough assessment of propagated ROIs by the treating physician is recommended.

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Title: Accuracy of deformable image registration for contour propagation in adaptive lung radiotherapy
Authors: Nicholas Hardcastle
Wouter van Elmpt
Dirk De Ruysscher
Karl Bzdusek
Wolfgang A Tomé
Publication date: 01-12-2013
Publisher: BioMed Central
Published in: Radiation Oncology / Issue 1/2013
Electronic ISSN: 1748-717X
DOI: https://doi.org/10.1186/1748-717X-8-243

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Accuracy of deformable image registration for contour propagation in adaptive lung radiotherapy

Abstract

Background

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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