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Radiation Oncology
Published in: Radiation Oncology 1/2015

Open Access 01-12-2015 | Research

Pelvic MRI findings in relapsed prostate cancer after radical prostatectomy

Authors: D. Hernandez, D. Salas, D. Giménez, P. Buitrago, S. Esquena, J. Palou, P. de la Torre, J. Pernas, I. Gich, G. Gómez de Segura, J. Craven-Bartle, G. Sancho

Published in: Radiation Oncology | Issue 1/2015

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Abstract

Purpose/Objective

Little is known about the clinical impact of using multiparametric MRI to plan early salvage radiotherapy after radical prostatectomy. We aimed to evaluate the incidence and location of recurrence based on pelvic multiparametric MRI findings and to identify clinical variables predictive of positive imaging results.

Materials and methods

We defined radiological criteria of local and lymph node malignancy and reviewed records and MRI studies of 70 patients with PSA recurrence after radical prostatectomy. We performed univariate and multivariate analysis to identify any association between clinical, pathological and treatment-related variables and imaging results.

Results

Multiparametric MRI was positive in 33/70 patients. We found local and lymph node recurrence in 27 patients and 7 patients, respectively, with a median PSA value of 0.38 ng/ml. We found no statistically significant differences between patients with positive and negative multiparametric MRI for any variable. Shorter PSADT was associated with positive lymph nodes (median PSADT: 5.12 vs 12.70 months; p: 0.017).

Conclusions

Nearly half the patients had visible disease in multiparametric MRI despite low PSA. Positive lymph nodes incidence should be considered when planning salvage radiotherapy, particularly in patients with a short PSADT.
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Metadata
Title
Pelvic MRI findings in relapsed prostate cancer after radical prostatectomy
Authors
D. Hernandez
D. Salas
D. Giménez
P. Buitrago
S. Esquena
J. Palou
P. de la Torre
J. Pernas
I. Gich
G. Gómez de Segura
J. Craven-Bartle
G. Sancho
Publication date
01-12-2015
Publisher
BioMed Central
Published in
Radiation Oncology / Issue 1/2015
Electronic ISSN: 1748-717X
DOI
https://doi.org/10.1186/s13014-015-0574-6

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