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01-03-2009 | Urogenital

Endorectal magnetic resonance imaging at 1.5 Tesla to assess local recurrence following radical prostatectomy using T2-weighted and contrast-enhanced imaging

Authors: Stefano Cirillo, Massimo Petracchini, Lorenza Scotti, Teresa Gallo, Annalisa Macera, Maria Cristina Bona, Cinzia Ortega, Pietro Gabriele, Daniele Regge

Published in: European Radiology | Issue 3/2009

Abstract

To evaluate diagnostic performance of endorectal magnetic resonance (eMR) for diagnosing local recurrence of prostate cancer (PC) in patients with previous radical prostatectomy (RP) and to assess whether contrast-enhanced (CE)-eMR improved diagnostic accuracy in comparison to unenhanced study. Unenhanced eMR data of 72 male patients (mean of total PSA: 1.23 ± 1.3 ng/ml) with previous RP were interpreted retrospectively and classified either as normal or suspicious for local recurrence. All eMR examinations were re-evaluated also on CE-eMR 4 months after the first reading. Images were acquired on a 1.5-T system. These data were compared to the standard of reference for local recurrence: prostatectomy bed biopsy results; choline positron emission tomography results; PSA reduction or increase after pelvic radiotherapy; PSA modification during active surveillance. Sensitivity, specificity, predictive positive value, negative predictive value and accuracy were 61.4%, 82.1%, 84.4%, 57.5% and 69.4% for unenhanced eMR and 84.1%, 89.3%, 92.5%, 78.1% and 86.1% for CE-eMR. A statistically significant difference was found between accuracy and sensitivity of the two evaluations (χ² = 5.33; p = 0.02 and χ² = 9.00; p = 0.0027). EMR had great accuracy for visualizing local recurrence of PC after RP. CE-eMR improved diagnostic performance in comparison with T2-weighted imaging alone.

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Title: Endorectal magnetic resonance imaging at 1.5 Tesla to assess local recurrence following radical prostatectomy using T2-weighted and contrast-enhanced imaging
Authors: Stefano Cirillo
Massimo Petracchini
Lorenza Scotti
Teresa Gallo
Annalisa Macera
Maria Cristina Bona
Cinzia Ortega
Pietro Gabriele
Daniele Regge
Publication date: 01-03-2009
Publisher: Springer-Verlag
Published in: European Radiology / Issue 3/2009
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-008-1174-8

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Endorectal magnetic resonance imaging at 1.5 Tesla to assess local recurrence following radical prostatectomy using T2-weighted and contrast-enhanced imaging

Abstract

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

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