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Diagnostic Pathology

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Open Access 01-12-2014 | Review

Different approaches for interpretation and reporting of immunohistochemistry analysis results in the bone tissue – a review

Authors: Nickolay Fedchenko, Janin Reifenrath

Published in: Diagnostic Pathology | Issue 1/2014

Abstract

Background

Immunohistochemistry (IHC) is a well-established, widely accepted method in both clinical and experimental parts of medical science. It allows receiving valuable information about any process in any tissue, and especially in bone. Each year the amount of data, received by IHC, grows in geometric progression. But the lack of standardization, especially on the post-analytical stage (interpreting and reporting of results), makes the comparison of the results of different studies impossible.

Methods

Comprehensive PubMED literature search with a combination of search words “immunohistochemistry” and “scoring system” was performed and 773 articles describing IHC results were identified. After further manual analysis 120 articles were selected for detailed evaluation of used approaches.

Results

Six major approaches to the interpretation and presentation of IHC analysis results were identified, analyzed and described.

Conclusions

The overview of the existing approaches in evaluation and interpretation of IHC data, which are provided in the article, can be used in bone tissue research and for either better understanding of existing scoring systems or developing a new one. Standard multiparametric, semiquantitative IHC scoring systems should simplify and clarify the process of interpretation and reporting of received data.

Virtual slides

The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/13000_2014_221

Available only for authorised users

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Title: Different approaches for interpretation and reporting of immunohistochemistry analysis results in the bone tissue – a review
Authors: Nickolay Fedchenko
Janin Reifenrath
Publication date: 01-12-2014
Publisher: BioMed Central
Published in: Diagnostic Pathology / Issue 1/2014
Electronic ISSN: 1746-1596
DOI: https://doi.org/10.1186/s13000-014-0221-9

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Different approaches for interpretation and reporting of immunohistochemistry analysis results in the bone tissue – a review

Abstract

Background

Methods

Results

Conclusions

Virtual slides

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

Virtual slides

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