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Open Access 01-12-2017 | Short Paper

Comparison of the sagittal sinus cross-sectional area between patients with multiple sclerosis, hydrocephalus, intracranial hypertension and spontaneous intracranial hypotension: a surrogate marker of venous transmural pressure?

Authors: Grant A. Bateman, Jeannette Lechner-Scott, Ross Copping, Christopher Moeskops, Swee Leong Yap

Published in: Fluids and Barriers of the CNS | Issue 1/2017

Abstract

There is evidence that patients with multiple sclerosis (MS) and hydrocephalus share some common pathophysiological mechanisms. Alterations in CSF pressure are known to affect cerebral venous sinus geometry. To further explore these mechanisms, we measured the superior sagittal sinus (SSS) cross-sectional area 3 cm above the torcular using T2 images in 20 MS, 10 spontaneous intracranial hypotension (SIH), 21 hydrocephalus and 20 idiopathic intracranial hypertension (IIH) patients and compared with 20 matched controls. The SSS area was reduced by 25% in hydrocephalus (p = 0.0008), increased by 22% (p = 0.037) in SIH and unchanged in IIH compared to matched controls. In MS there was a 16% increase in SSS area (p = 0.01).The findings suggest that changes in SSS cross-sectional are common between MS and SIH patients, while in hydrocephalus and IIH these are different.

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Title: Comparison of the sagittal sinus cross-sectional area between patients with multiple sclerosis, hydrocephalus, intracranial hypertension and spontaneous intracranial hypotension: a surrogate marker of venous transmural pressure?
Authors: Grant A. Bateman
Jeannette Lechner-Scott
Ross Copping
Christopher Moeskops
Swee Leong Yap
Publication date: 01-12-2017
Publisher: BioMed Central
Published in: Fluids and Barriers of the CNS / Issue 1/2017
Electronic ISSN: 2045-8118
DOI: https://doi.org/10.1186/s12987-017-0066-1

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Comparison of the sagittal sinus cross-sectional area between patients with multiple sclerosis, hydrocephalus, intracranial hypertension and spontaneous intracranial hypotension: a surrogate marker of venous transmural pressure?

Abstract

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