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Virology Journal
Published in: Virology Journal 1/2023

Open Access 01-12-2023 | Acute Gastroenteritis | Research

Molecular epidemiology analysis of symptomatic and asymptomatic norovirus infections in Chinese infants

Authors: Li-Na Chen, Si-Jie Wang, Song-Mei Wang, Xiao-Li Fu, Wen-Jing Zheng, Zhi-Yong Hao, Hai-Song Zhou, Xin-Jiang Zhang, Yu-Liang Zhao, Chao Qiu, Lorenz von Seidlein, Tian-Yi Qiu, Xuan-Yi Wang

Published in: Virology Journal | Issue 1/2023

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Abstract

Background

Norovirus is a leading cause of acute gastroenteritis among children. Previous studies based on symptomatic infections indicated that mutations, rather than recombination drove the evolution of the norovirus ORF2. These characteristics were found in hospital-based symptomatic infections, whereas, asymptomatic infections are frequent and contribute significantly to transmission.

Methods

We conducted the first norovirus molecular epidemiology analysis covering both symptomatic and asymptomatic infections derived from a birth cohort study in the northern China.

Results

During the study, 14 symptomatic and 20 asymptomatic norovirus infections were detected in 32 infants. Out of the 14 strains that caused symptomatic infections, 12 strains were identified as GII.3[P12], and others were GII.4[P31]. Conversely, 17 asymptomatic infections were caused by GII.4[P31], two by GII.2[P16], and one by GII.4[P16]. Regardless of symptomatic and asymptomatic infections, the mutations were detected frequently in the ORF2 region, and almost all recombination were identified in the RdRp-ORF2 region. The majority of the mutations were located around the predefined epitope regions of P2 subdomain indicating a potential for immune evasion.

Conclusion

The role of symptomatic as well as asymptomatic infections in the evolution of norovirus needs to be evaluated continuously.
Appendix
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Metadata
Title
Molecular epidemiology analysis of symptomatic and asymptomatic norovirus infections in Chinese infants
Authors
Li-Na Chen
Si-Jie Wang
Song-Mei Wang
Xiao-Li Fu
Wen-Jing Zheng
Zhi-Yong Hao
Hai-Song Zhou
Xin-Jiang Zhang
Yu-Liang Zhao
Chao Qiu
Lorenz von Seidlein
Tian-Yi Qiu
Xuan-Yi Wang
Publication date
01-12-2023
Publisher
BioMed Central
Published in
Virology Journal / Issue 1/2023
Electronic ISSN: 1743-422X
DOI
https://doi.org/10.1186/s12985-023-02024-z

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