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Virology Journal
Published in: Virology Journal 1/2021

Open Access 01-12-2021 | Hepatitis B | Research

Cross-sectional retrospective analysis of clinical characteristics of chronic hepatitis B patients with oral antiviral treatment in eastern China

Authors: Jueqing Gu, Guodong Yu, Xiaoli Zhang, Shanyan Zhang, Huan Cai, Chanyuan Ye, Yida Yang, Dezhou Li, Zhaowei Tong, Huajiang Shen, Huazhong Chen, Feng Ding, Xijie Lai, Junyan Liu, Meiling Xu, Weiti Wu

Published in: Virology Journal | Issue 1/2021

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Abstract

Background

In China, more than 20 million patients with chronic hepatitis B need antiviral treatment. Side effects of antiviral treatment such as renal complications can be problematic, particularly in an aging population.

Methods

The data were retrospectively extracted from the hospital medical charts of five centers in eastern China from January 1 to December 31, 2018.

Results

A total of 8309 patients with CHB was enrolled in this study. The median age of the patients was 46 years. The prevalence of diabetes mellitus, hypertension, and hepatic cirrhosis was respectively 3.49%, 4.42%, and 23.72%. The prevalence of these comorbidities increased with age (P < 0.001). Of the patients with CHB, 5332 had complete renal function results. Among them, patients with an estimated glomerular filtration rate of < 60 mL/min/1.73m2 accounted for 4.14%, and those with proteinuria for 8.33%. According to the definition of chronic kidney disease, the proportion of patients with chronic kidney disease was 11.37%. The prevalence of chronic kidney disease increased with age (P < 0.001). In a multivariate analysis, age group [odds ratio (OR) = 2.387], diabetes mellitus (OR = 1.486), hypertension (OR = 2.557), hepatic cirrhosis (OR = 1.295), and a history of exposure to adefovir dipivoxil (OR = 1.644) were significantly associated with CKD (P < 0.05). Among patients with CKD, 17.66% (107/606) had a history of lamivudine exposure, and 34.65% (210/606) had a history of nucleotide analogue exposure

Conclusion

The management of Chinese patients with CHB should take into consideration age, previous medication history, and renal impairment.
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Metadata
Title
Cross-sectional retrospective analysis of clinical characteristics of chronic hepatitis B patients with oral antiviral treatment in eastern China
Authors
Jueqing Gu
Guodong Yu
Xiaoli Zhang
Shanyan Zhang
Huan Cai
Chanyuan Ye
Yida Yang
Dezhou Li
Zhaowei Tong
Huajiang Shen
Huazhong Chen
Feng Ding
Xijie Lai
Junyan Liu
Meiling Xu
Weiti Wu
Publication date
01-12-2021
Publisher
BioMed Central
Published in
Virology Journal / Issue 1/2021
Electronic ISSN: 1743-422X
DOI
https://doi.org/10.1186/s12985-021-01491-6

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