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Open Access 01-12-2020 | Urothelial Cancer | Research

BK polyomavirus infection promotes growth and aggressiveness in bladder cancer

Authors: Yigang Zeng, Jiajia Sun, Juan Bao, Tongyu Zhu

Published in: Virology Journal | Issue 1/2020

Abstract

Background

Recent studies have confirmed the integration of the BK polyomavirus (BKPyV) gene into the cellular genome of urothelial carcinomas in transplant recipients, further confirming the correlation between BKPyV and urothelial carcinomas after transplantation. However, the role BKPyV infections play in the biological function of bladder cancer remains unclear.

Methods

We developed a BKPyV-infected bladder cancer cell model and a mice tumor model to discuss the role of BKPyV infections.

Results

Our research proves that BKPyV infections promote the proliferation, invasion and migration of bladder cancer cells, while the activation of β-catenin signaling pathway is one of its mediation mechanisms.

Conclusions

We first described BKPyV infection promotes the proliferation, invasion and migration of bladder cancer. We verified the role of β-catenin signaling pathway and Epithelial-Mesenchymal Transition effect in BKPyV-infected bladder cancer. These results provide meaningful information towards the diagnosis and treatment of clinical bladder cancer.

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Title: BK polyomavirus infection promotes growth and aggressiveness in bladder cancer
Authors: Yigang Zeng
Jiajia Sun
Juan Bao
Tongyu Zhu
Publication date: 01-12-2020
Publisher: BioMed Central
Keywords: Urothelial Cancer
Urothelial Cancer
Published in: Virology Journal / Issue 1/2020
Electronic ISSN: 1743-422X
DOI: https://doi.org/10.1186/s12985-020-01399-7

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