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Open Access 01-12-2018 | Research

Evaluation of candidate genes associated with hepatitis A and E virus infection in Chinese Han population

Authors: Maolin Gu, Jing Qiu, Daoxia Guo, Yunfang Xu, Xingxiang Liu, Chong Shen, Chen Dong

Published in: Virology Journal | Issue 1/2018

Abstract

Background

Recent GWAS-associated studies reported that single nucleotide polymorphisms (SNPs) in ABCB1, TGFβ1, XRCC1 genes were associated with hepatitis A virus (HAV) infection, and variants of APOA4 and APOE genes were associated with and hepatitis E virus (HEV) infection in US population. However, the associations of these loci with HAV or HEV infection in Chinese Han population remain unclear.

Methods

A total of 3082 Chinese Han persons were included in this study. Anti-HAV IgG and anti-HEV IgG were detected by enzyme-linked immunosorbent assay (ELISA). Genotypes in ABCB1, TGFβ1, XRCC1, APOA4 and APOE SNPs were determined by TaqMan MGB technology.

Results

In Chinese Han population, rs1045642 C to T variation in ABCB1 was significantly associated with the decreased risk of HAV infection (P < 0.05). However, the effect direction was different with the previous US study. Rs1001581 A to G variation in XRCC1, which was not identified in US population, was significantly associated with the protection against HAV infection in our samples (P < 0.05). In addition, our results suggested that rs7412 C to T variation in APOE was significantly associated with lower risk of HEV infection in males (adjusted OR < 1.0, P < 0.05) but not in females.

Conclusions

ABCB1 and XRCC1 genes variants are significantly associated with the protection against HAV infection. Additionally, Chinese Han males with rs7412 C to T variation in APOE gene are less prone to be infected by HEV.

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Title: Evaluation of candidate genes associated with hepatitis A and E virus infection in Chinese Han population
Authors: Maolin Gu
Jing Qiu
Daoxia Guo
Yunfang Xu
Xingxiang Liu
Chong Shen
Chen Dong
Publication date: 01-12-2018
Publisher: BioMed Central
Published in: Virology Journal / Issue 1/2018
Electronic ISSN: 1743-422X
DOI: https://doi.org/10.1186/s12985-018-0962-2

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Evaluation of candidate genes associated with hepatitis A and E virus infection in Chinese Han population

Abstract

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Results

Conclusions

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Abstract

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