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Virology Journal
Published in: Virology Journal 1/2017

Open Access 01-12-2017 | Research

Genome-wide analysis of codon usage bias in Bovine Coronavirus

Authors: Matías Castells, Matías Victoria, Rodney Colina, Héctor Musto, Juan Cristina

Published in: Virology Journal | Issue 1/2017

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Abstract

Background

Bovine coronavirus (BCoV) belong to the genus Betacoronavirus of the family Coronaviridae. BCoV are widespread around the world and cause enteric or respiratory infections among cattle, leading to important economic losses to the beef and dairy industry worldwide. To study the relation of codon usage among viruses and their hosts is essential to understand host-pathogen interaction, evasion from host’s immune system and evolution.

Methods

We performed a comprehensive analysis of codon usage and composition of BCoV.

Results

The global codon usage among BCoV strains is similar. Significant differences of codon preferences in BCoV genes in relation to codon usage of Bos taurus host genes were found. Most of the highly frequent codons are U-ending. G + C compositional constraint and dinucleotide composition also plays a role in the overall pattern of BCoV codon usage.

Conclusions

The results of these studies revealed that mutational bias is a leading force shaping codon usage in this virus. Additionally, relative dinucleotide frequencies, geographical distribution, and evolutionary processes also influenced the codon usage pattern.
Appendix
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Metadata
Title
Genome-wide analysis of codon usage bias in Bovine Coronavirus
Authors
Matías Castells
Matías Victoria
Rodney Colina
Héctor Musto
Juan Cristina
Publication date
01-12-2017
Publisher
BioMed Central
Published in
Virology Journal / Issue 1/2017
Electronic ISSN: 1743-422X
DOI
https://doi.org/10.1186/s12985-017-0780-y

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