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Virology Journal
Published in: Virology Journal 1/2017

Open Access 01-12-2017 | Short report

The sense behind retroviral anti-sense transcription

Authors: Mamneet Manghera, Alycia Magnusson, Renée N. Douville

Published in: Virology Journal | Issue 1/2017

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Abstract

Retroviruses are known to rely extensively on the expression of viral proteins from the sense proviral genomic strand. Yet, the production of regulatory retroviral proteins from antisense-encoded viral genes is gaining research attention, due to their clinical significance. This report will discuss what is known about antisense transcription in Retroviridae, and provide new information about antisense transcriptional regulation through a comparison of Human Immunodeficiency Virus (HIV), Human T-cell Lymphotrophic Virus (HTLV-1) and endogenous retrovirus-K (ERVK) long terminal repeats (LTRs). We will attempt to demonstrate that the potential for antisense transcription is more widespread within retroviruses than has been previously appreciated, with this feature being the rule, rather than the exception.
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Metadata
Title
The sense behind retroviral anti-sense transcription
Authors
Mamneet Manghera
Alycia Magnusson
Renée N. Douville
Publication date
01-12-2017
Publisher
BioMed Central
Published in
Virology Journal / Issue 1/2017
Electronic ISSN: 1743-422X
DOI
https://doi.org/10.1186/s12985-016-0667-3

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