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Virology Journal
Published in: Virology Journal 1/2016

Open Access 01-12-2016 | Short report

Immunohistochemical insights into Saffold virus infection of the brain of juvenile AG129 mice

Authors: Shawn Zheng Kai Tan, Mookkan Prabakaran

Published in: Virology Journal | Issue 1/2016

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Abstract

Background

Saffold Virus (SAFV) is a human cardiovirus that is suspected of causing infection of the central nervous system (CNS) in children. While recent animal studies have started to elucidate the pathogenesis of SAFV, very little is known about the mechanisms behind it.

Method

In this study, we attempted to elucidate some of the mechanisms of the pathogenesis of SAFV in the brain of a juvenile mouse model by using immunohistochemical methods.

Results

We first showed that SAFV is able to infect both neuronal and glial cells in the brain of 2 week-old AG129 mice. We then showed that SAFV is able to induce apoptosis in both neuronal and glial cells in the brain. Lastly, we showed that SAFV infection does not show any signs of gross demyelination in the brain.

Conclusion

Overall, our results provide important insights into the mechanisms of SAFV in the brain.
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Metadata
Title
Immunohistochemical insights into Saffold virus infection of the brain of juvenile AG129 mice
Authors
Shawn Zheng Kai Tan
Mookkan Prabakaran
Publication date
01-12-2016
Publisher
BioMed Central
Published in
Virology Journal / Issue 1/2016
Electronic ISSN: 1743-422X
DOI
https://doi.org/10.1186/s12985-016-0654-8

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