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Virology Journal
Published in: Virology Journal 1/2016

Open Access 01-12-2016 | Review

Flavivirus NS1: a multifaceted enigmatic viral protein

Authors: Meghana Rastogi, Nikhil Sharma, Sunit Kumar Singh

Published in: Virology Journal | Issue 1/2016

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Abstract

Flaviviruses are emerging arthropod-borne viruses representing an immense global health problem. The prominent viruses of this group include dengue virus, yellow fever virus, Japanese encephalitis virus, West Nile virus tick borne encephalitis virus and Zika Virus. These are endemic in many parts of the world. They are responsible for the illness ranging from mild flu like symptoms to severe hemorrhagic, neurologic and cognitive manifestations leading to death. NS1 is a highly conserved non-structural protein among flaviviruses, which exist in diverse forms. The intracellular dimer form of NS1 plays role in genome replication, whereas, the secreted hexamer plays role in immune evasion. The secreted NS1 has been identified as a potential diagnostic marker for early detection of the infections caused by flaviviruses. In addition to the diagnostic marker, the importance of NS1 has been reported in the development of therapeutics. NS1 based subunit vaccines are at various stages of development. The structural details and diverse functions of NS1 have been discussed in detail in this review.
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Metadata
Title
Flavivirus NS1: a multifaceted enigmatic viral protein
Authors
Meghana Rastogi
Nikhil Sharma
Sunit Kumar Singh
Publication date
01-12-2016
Publisher
BioMed Central
Published in
Virology Journal / Issue 1/2016
Electronic ISSN: 1743-422X
DOI
https://doi.org/10.1186/s12985-016-0590-7

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