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01-12-2020 | Rheumatoid Arthritis | Review

Accelerated immunosenescence in rheumatoid arthritis: impact on clinical progression

Author: Moisés E. Bauer

Published in: Immunity & Ageing | Issue 1/2020

Abstract

Patients with rheumatoid arthritis (RA) develop features of accelerated ageing, including immunosenescence. These changes include decreased thymic functionality, expansion of late-differentiated effector T cells, increased telomeric attrition, and excessive production of cytokines (senescence-associated secretory phenotype). The progression of RA has been associated with the early development of age-related co-morbidities, including osteoporosis, cardiovascular complications, and cognitive impairment. Here I review data supporting the hypothesis that immune-senescence contributes to the aggravation of both articular and extra-articular manifestations. Of note, poor cognitive functions in RA were associated with senescent CD28- T cells, inflammaging, and autoantibodies against brain antigens. The pathways of immune-to-brain communication are discussed and provide the rationale for the cognitive impairment reported in RA.

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Title: Accelerated immunosenescence in rheumatoid arthritis: impact on clinical progression
Author: Moisés E. Bauer
Publication date: 01-12-2020
Publisher: BioMed Central
Keywords: Rheumatoid Arthritis
Cytokines
Published in: Immunity & Ageing / Issue 1/2020
Electronic ISSN: 1742-4933
DOI: https://doi.org/10.1186/s12979-020-00178-w

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