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Open Access 01-12-2017 | Short report

Low expression of CD39 and CD73 genes in centenarians compared with octogenarians

Authors: Almudena Crooke, Juan Martínez-Henández, Joaquín Martínez-López, Alfonso Cruz-Jentoft, Fernando Huete-Toral, Jesús Pintor

Published in: Immunity & Ageing | Issue 1/2017

Abstract

Ageing involves a progressive decline of the body’s regulatory systems including immune system. Adenosine regulates immune function by interaction with its receptors, mainly adenosine A2A receptor, present on the surface of immune cells. Furthermore, cellular response to this nucleoside is highly dependent on its extracellular concentration that is regulated by ecto-enzymes such as CD39 and CD73. Therefore, the aim of this study was to investigate the effect of age on adenosine A2A receptor, CD39 and CD73 gene expression. Changes in mRNA were measured by quantitative PCR from peripheral blood of young, middle-aged and older adults as well as centenarians. Centenarians showed a prominent decrease of CD39 and CD73 mRNA in comparison with older adults. Regarding to adenosine A2A receptor, we detected two subgroups of centenarians with high and low level of transcript. Additionally, adenosine A2A receptor mRNA level of centenarians, did not correlate with their cognitive impairment. In summary, our pilot study suggests that unlike of adenosine A2A receptor, the level of CD39 as well as CD73 mRNA could be a hallmark of successful human ageing.

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Title: Low expression of CD39 and CD73 genes in centenarians compared with octogenarians
Authors: Almudena Crooke
Juan Martínez-Henández
Joaquín Martínez-López
Alfonso Cruz-Jentoft
Fernando Huete-Toral
Jesús Pintor
Publication date: 01-12-2017
Publisher: BioMed Central
Published in: Immunity & Ageing / Issue 1/2017
Electronic ISSN: 1742-4933
DOI: https://doi.org/10.1186/s12979-017-0094-3

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