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Journal of Translational Medicine
Published in: Journal of Translational Medicine 1/2022

Open Access 01-12-2022 | Nutrition | Research

Combined association of triglyceride-glucose index and systolic blood pressure with all-cause and cardiovascular mortality among the general population

Authors: Yu Yu, Min Gu, Hao Huang, Sijing Cheng, Yu Deng, Chi Cai, Xuhua Chen, Hongxia Niu, Xiaohui Ning, Wei Hua

Published in: Journal of Translational Medicine | Issue 1/2022

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Abstract

Background

The combined association of triglyceride-glucose (TyG) index and different systolic blood pressure (SBP) levels with all-cause and cardiovascular mortality among the general population remains unclear.

Methods

In this study, 6245 individuals were from the National Health and Nutrition Examination Survey (1999–2002). The study endpoints were all-cause and cardiovascular mortality. Multivariate Cox proportional hazards regression models were used to explore the combined association of TyG index and different SBP levels with all-cause and cardiovascular mortality.

Results

During a mean follow-up period of 66.8 months, a total of 284 all-cause deaths (331/100000 person-years) and 61 cardiovascular deaths (66/100000 person-years) were recorded. Multivariate Cox regression analysis revealed that the combination of low TyG index and low SBP (< 120 mmHg and < 130 mmHg) was associated with a reduced risk of all-cause and cardiovascular mortality than others. However, survival benefit was not observed in the combined group with the low TyG index and SBP < 140 mmHg. Furthermore, the mortality rate in the combined group of low TyG index and low SBP gradually increased with the elevation of SBP level.

Conclusion

The combination of low TyG index and low SBP (< 120 mmHg and < 130 mmHg) was associated with a lower risk of all-cause and cardiovascular mortality. However, no survival benefit was observed in the combined group of low TyG index and SBP < 140 mmHg.
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Metadata
Title
Combined association of triglyceride-glucose index and systolic blood pressure with all-cause and cardiovascular mortality among the general population
Authors
Yu Yu
Min Gu
Hao Huang
Sijing Cheng
Yu Deng
Chi Cai
Xuhua Chen
Hongxia Niu
Xiaohui Ning
Wei Hua
Publication date
01-12-2022
Publisher
BioMed Central
Keyword
Nutrition
Published in
Journal of Translational Medicine / Issue 1/2022
Electronic ISSN: 1479-5876
DOI
https://doi.org/10.1186/s12967-022-03678-z

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