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Journal of Translational Medicine
Published in: Journal of Translational Medicine 1/2022

Open Access 01-12-2022 | Obesity | Research

Effects of high-intensity interval training on improving arterial stiffness in Chinese female university students with normal weight obese: a pilot randomized controlled trial

Authors: Jingyun Hu, Min Liu, Ruoyu Yang, Liyan Wang, Leichao Liang, Yuanyuan Yang, Shihao Jia, Ruiyi Chen, Qianle Liu, Yu Ren, Lei Zhu, Ming Cai

Published in: Journal of Translational Medicine | Issue 1/2022

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Abstract

Background

High intensity interval training (HIIT) has been reported to exert better effects on cardiovascular fitness in obesity, but little known about the arterial stiffness (AS) in female university students with normal weight obesity (NWO). Thus, this study aimed to investigate the effects of HIIT on the body composition, heart rate (HR), blood pressure (BP), blood lipids metabolism as well as the novel parameters of propensity for AS (arterial velocity pulse index [AVI], arterial pressure volume index [API]) for female university students with NWO.

Methods

Forty female university students with NWO were randomly assigned to control group (n = 20) and HIIT group (3 bouts of 9‑min intervals at 90% of the maximal heart rate [HRmax], interspersed by 1 min rest, 5 days a week, n = 20). Tests were performed before and after 4 weeks of training. Repeated measures ANOVA and simple effect test analysis were used to analyze dependent variable changes.

Results

After 4 weeks HIIT statistically significantly improved the body composition by decreasing the body mass index, body fat percent, total body fat mass (BFM), BFM of left arm, measured circumference of left arm, and obesity degree, and increasing the total body skeletal muscle mass, protein content, total body water, fat free mass, body cell mas, and InBody score. HIIT also statistically significantly decreased the HR and BP. As for the lipid profile, HIIT obviously ameliorated the blood lipids metabolism by decreasing the levels of total cholesterol (TC), triglyceride, low-density lipoprotein, and TC/HDL, and increasing the levels of high-density lipoprotein (HDL). In addition, the AVI and API were markedly decreased via HIIT intervention.

Conclusions

HIIT produced significant and meaningful benefits for body composition, HR, BP, and blood lipids metabolism, and could decrease AS in female university students with NWO. This suggests that HIIT may effectively reduce the risk of arteriosclerosis and protect the cardiovascular function for female university students with NWO.
Trial registration ChiCTR2100050711. Registered 3 September 2021. Retrospectively registered.
Literature
1.
Oliveros E, Somers VK, Sochor O, Goel K, Lopez-Jimenez F. The concept of normal weight obesity. Prog Cardiovasc Dis. 2014;56:426–33.PubMed
2.
Maitiniyazi G, Chen Y, Qiu YY, Xie ZX, He JY, Xia SF. Characteristics of body composition and lifestyle in Chinese University students with normal-weight obesity: a cross-sectional study. Diabetes Metab Syndr Obes. 2021;14:3427–36.PubMedPubMedCentral
3.
4.
5.
Juarascio A, Forman E, Timko CA, Butryn M, Goodwin C. The development and validation of the food craving acceptance and action questionnaire (FAAQ). Eat Behav. 2011;12:182–7.PubMed
6.
Zhang M, Schumann M, Huang T, Tormakangas T, Cheng S. Normal weight obesity and physical fitness in Chinese university students: an overlooked association. BMC Public Health. 2018;18:1334.PubMedPubMedCentral
7.
Tian Q, Wang H, Kaudimba KK, Guo S, Zhang H, Gao S, Wang R, Luan X, Lee JKW, Chen P, et al. Characteristics of physical fitness and cardiometabolic risk in Chinese university students with normal-weight obesity: a cross-sectional study. Diabetes Metab Syndr Obes. 2020;13:4157–67.PubMedPubMedCentral
8.
Yusuf S, Hawken S, Ounpuu S, Bautista L, Franzosi MG, Commerford P, Lang CC, Rumboldt Z, Onen CL, Lisheng L, et al. Obesity and the risk of myocardial infarction in 27,000 participants from 52 countries: a case-control study. Lancet. 2005;366:1640–9.PubMed
9.
Despres JP, Lemieux I. Abdominal obesity and metabolic syndrome. Nature. 2006;444:881–7.PubMed
10.
De Lorenzo A, Martinoli R, Vaia F, Di Renzo L. Normal weight obese (NWO) women: an evaluation of a candidate new syndrome. Nutr Metab Cardiovasc Dis. 2006;16:513–23.PubMed
11.
12.
Kim S, Kyung C, Park JS, Lee SP, Kim HK, Ahn CW, Kim KR, Kang S. Normal-weight obesity is associated with increased risk of subclinical atherosclerosis. Cardiovasc Diabetol. 2015;14:58.PubMedPubMedCentral
13.
Fujiwara K, Shimada K, Nishitani-Yokoyama M, Kunimoto M, Matsubara T, Matsumori R, Abulimiti A, Aikawa T, Ouchi S, Shimizu M, et al. Arterial stiffness index and exercise tolerance in patients undergoing cardiac rehabilitation. Int Heart J. 2021;62:230–7.PubMed
14.
Sueta D, Yamamoto E, Tanaka T, Hirata Y, Sakamoto K, Tsujita K, Kojima S, Nishiyama K, Kaikita K, Hokimoto S, et al. The accuracy of central blood pressure waveform by novel mathematical transformation of non-invasive measurement. Int J Cardiol. 2015;189:244–6.PubMed
15.
Komine H, Asai Y, Yokoi T, Yoshizawa M. Non-invasive assessment of arterial stiffness using oscillometric blood pressure measurement. Biomed Eng Online. 2012;11:6.PubMedPubMedCentral
16.
Okamoto M, Nakamura F, Musha T, Kobayashi Y. Association between novel arterial stiffness indices and risk factors of cardiovascular disease. BMC Cardiovasc Disord. 2016;16:211.PubMedPubMedCentral
17.
Zhang Y, Yin P, Xu Z, Xie Y, Wang C, Fan Y, Liang F, Yin Z. Non-invasive assessment of early atherosclerosis based on new arterial stiffness indices measured with an upper-arm oscillometric device. Tohoku J Exp Med. 2017;241:263–70.PubMed
18.
Zhang H, Tong TK, Kong Z, Shi Q, Liu Y, Nie J. Exercise training-induced visceral fat loss in obese women: the role of training intensity and modality. Scand J Med Sci Sports. 2021;31:30–43.PubMed
19.
Robinson MM, Lowe VJ, Nair KS. Increased brain glucose uptake after 12 weeks of aerobic high-intensity interval training in young and older adults. J Clin Endocrinol Metab. 2018;103:221–7.PubMed
20.
Nokia MS, Lensu S, Ahtiainen JP, Johansson PP, Koch LG, Britton SL, Kainulainen H. Physical exercise increases adult hippocampal neurogenesis in male rats provided it is aerobic and sustained. J Physiol. 2016;594:1855–73.PubMedPubMedCentral
21.
Campbell WW, Kraus WE, Powell KE, Haskell WL, Janz KF, Jakicic JM, Troiano RP, Sprow K, Torres A, Piercy KL, et al. High-intensity interval training for cardiometabolic disease prevention. Med Sci Sports Exerc. 2019;51:1220–6.PubMedPubMedCentral
22.
Keating SE, Johnson NA, Mielke GI, Coombes JS. A systematic review and meta-analysis of interval training versus moderate-intensity continuous training on body adiposity. Obes Rev. 2017;18:943–64.PubMed
23.
Miguet M, Fearnbach NS, Metz L, Khammassi M, Julian V, Cardenoux C, Pereira B, Boirie Y, Duclos M, Thivel D. Effect of HIIT versus MICT on body composition and energy intake in dietary restrained and unrestrained adolescents with obesity. Appl Physiol Nutr Metab. 2020;45:437–45.PubMed
24.
Garcia-Hermoso A, Cerrillo-Urbina AJ, Herrera-Valenzuela T, Cristi-Montero C, Saavedra JM, Martinez-Vizcaino V. Is high-intensity interval training more effective on improving cardiometabolic risk and aerobic capacity than other forms of exercise in overweight and obese youth? A meta-analysis. Obes Rev. 2016;17:531–40.PubMed
25.
Su L, Fu J, Sun S, Zhao G, Cheng W, Dou C, Quan M. Effects of HIIT and MICT on cardiovascular risk factors in adults with overweight and/or obesity: a meta-analysis. PLoS ONE. 2019;14: e0210644.PubMedPubMedCentral
26.
Bartlett JD, Close GL, MacLaren DP, Gregson W, Drust B, Morton JP. High-intensity interval running is perceived to be more enjoyable than moderate-intensity continuous exercise: implications for exercise adherence. J Sports Sci. 2011;29:547–53.PubMed
27.
Reitlo LS, Sandbakk SB, Viken H, Aspvik NP, Ingebrigtsen JE, Tan X, Wisloff U, Stensvold D. Exercise patterns in older adults instructed to follow moderate- or high-intensity exercise protocol - the generation 100 study. BMC Geriatr. 2018;18:208.PubMedPubMedCentral
28.
Anderson JW, Konz EC. Obesity and disease management: effects of weight loss on comorbid conditions. Obes Res. 2001;9(Suppl 4):326S-334S.PubMed
29.
Kosmala W, Jedrzejuk D, Derzhko R, Przewlocka-Kosmala M, Mysiak A, Bednarek-Tupikowska G. Left ventricular function impairment in patients with normal-weight obesity: contribution of abdominal fat deposition, profibrotic state, reduced insulin sensitivity, and proinflammatory activation. Circ Cardiovasc Imaging. 2012;5:349–56.PubMed
30.
Tanaka H, Dinenno FA, Monahan KD, Clevenger CM, DeSouza CA, Seals DR. Aging, habitual exercise, and dynamic arterial compliance. Circulation. 2000;102:1270–5.PubMed
31.
Grassi G. Impact of heart rate on arterial stiffness: virtual vs. real assessment. J Hypertens. 2020;38:2382–3.PubMed
32.
Liu JJ, Liu S, Gurung RL, Ang K, Ee Tang W, Sum CF, Tavintharan S, Hadjadj S, Lim SC. Arterial stiffness modulates the association of resting heart rate with rapid renal function decline in individuals with type 2 diabetes mellitus. Arterioscler Thromb Vasc Biol. 2019;39:2437–44.PubMed
33.
Giannoglou GD, Chatzizisis YS, Zamboulis C, Parcharidis GE, Mikhailidis DP, Louridas GE. Elevated heart rate and atherosclerosis: an overview of the pathogenetic mechanisms. Int J Cardiol. 2008;126:302–12.PubMed
34.
Wu S, Jin C, Li S, Zheng X, Zhang X, Cui L, Gao X. Aging, arterial stiffness, and blood pressure association in chinese adults. Hypertension. 2019;73:893–9.PubMed
35.
Mitchell GF, Parise H, Benjamin EJ, Larson MG, Keyes MJ, Vita JA, Vasan RS, Levy D. Changes in arterial stiffness and wave reflection with advancing age in healthy men and women: the Framingham Heart Study. Hypertension. 2004;43:1239–45.PubMed
36.
Zhang Y, Gu Y, Chen Y, Huang Z, Li M, Jiang W, Chen J, Rao W, Luo S, Chen Y, et al. Dingxin Recipe IV attenuates atherosclerosis by regulating lipid metabolism through LXR-alpha/SREBP1 pathway and modulating the gut microbiota in ApoE(-/-) mice fed with HFD. J Ethnopharmacol. 2021;266: 113436.PubMed
37.
Peters EB, Kibbe MR. Nanomaterials to resolve atherosclerosis. ACS Biomater Sci Eng. 2020;6:3693–712.PubMed
38.
39.
Gupta M, Blumenthal C, Chatterjee S, Bandyopadhyay D, Jain V, Lavie CJ, Virani SS, Ray KK, Aronow WS, Ghosh RK. Novel emerging therapies in atherosclerosis targeting lipid metabolism. Expert Opin Investig Drugs. 2020;29:611–22.PubMed
40.
Sandesara PB, Virani SS, Fazio S, Shapiro MD. The forgotten lipids: triglycerides, remnant cholesterol, and atherosclerotic cardiovascular disease risk. Endocr Rev. 2019;40:537–57.PubMed
41.
42.
Agirbasli M, Tanrikulu A, Acar Sevim B, Azizy M, Bekiroglu N. Total cholesterol-to-high-density lipoprotein cholesterol ratio predicts high-sensitivity C-reactive protein levels in Turkish children. J Clin Lipidol. 2015;9:195–200.PubMed
43.
Yamanashi H, Koyamatsu J, Nagayoshi M, Shimizu Y, Kawashiri SY, Kondo H, Fukui S, Tamai M, Maeda T. Screening validity of arterial pressure-volume index and arterial velocity-pulse index for preclinical atherosclerosis in Japanese Community-dwelling adults: the Nagasaki Islands study. J Atheroscler Thromb. 2018;25:792–8.PubMedPubMedCentral
44.
Ueda T, Miura S, Suematsu Y, Shiga Y, Kuwano T, Sugihara M, Ike A, Iwata A, Nishikawa H, Fujimi K, Saku K. Association of arterial pressure volume index with the presence of significantly stenosed coronary vessels. J Clin Med Res. 2016;8:598–604.PubMedPubMedCentral
45.
Sasaki-Nakashima R, Kino T, Chen L, Doi H, Minegishi S, Abe K, Sugano T, Taguri M, Ishigami T. Successful prediction of cardiovascular risk by new non-invasive vascular indexes using suprasystolic cuff oscillometric waveform analysis. J Cardiol. 2017;69:30–7.PubMed
46.
Aroor AR, Jia G, Sowers JR. Cellular mechanisms underlying obesity-induced arterial stiffness. Am J Physiol Regul Integr Comp Physiol. 2018;314:R387–98.PubMed
47.
Jean N, Somers VK, Sochor O, Medina-Inojosa J, Llano EM, Lopez-Jimenez F. Normal-weight obesity: implications for cardiovascular health. Curr Atheroscler Rep. 2014;16:464.PubMed
48.
Vaccari F, Passaro A, D’Amuri A, Sanz JM, Di Vece F, Capatti E, Magnesa B, Comelli M, Mavelli I, Grassi B, et al. Effects of 3-month high-intensity interval training vs. moderate endurance training and 4-month follow-up on fat metabolism, cardiorespiratory function and mitochondrial respiration in obese adults. Eur J Appl Physiol. 2020;120:1787–803.PubMed
49.
Lazzer S, Tringali G, Caccavale M, De Micheli R, Abbruzzese L, Sartorio A. Effects of high-intensity interval training on physical capacities and substrate oxidation rate in obese adolescents. J Endocrinol Invest. 2017;40:217–26.PubMed
50.
MacInnis MJ, Gibala MJ. Physiological adaptations to interval training and the role of exercise intensity. J Physiol. 2017;595:2915–30.PubMed
51.
Blue MNM, Smith-Ryan AE, Trexler ET, Hirsch KR. The effects of high intensity interval training on muscle size and quality in overweight and obese adults. J Sci Med Sport. 2018;21:207–12.PubMed
52.
Plavsic L, Knezevic OM, Sovtic A, Minic P, Vukovic R, Mazibrada I, Stanojlovi O, Hrncic D, Rasic-Markovic A, Macut D. Effects of high-intensity interval training and nutrition advice on cardiometabolic markers and aerobic fitness in adolescent girls with obesity. Appl Physiol Nutr Metab. 2020;45:294–300.PubMed
53.
Ramírez-Vélez R, Hernández-Quiñones PA, Tordecilla-Sanders A, Álvarez C, Ramírez-Campillo R, Izquierdo M, Correa-Bautista JE, Garcia-Hermoso A, Garcia RG. Effectiveness of HIIT compared to moderate continuous training in improving vascular parameters in inactive adults. Lipids Health Dis. 2019;8:42.
54.
Maillard F, Rousset S, Pereira B, Traore A, Del Amaze PD, Boirie Y, Duclos M, Boisseau N. High-intensity interval training reduces abdominal fat mass in postmenopausal women with type 2 diabetes. Diabetes Metab. 2016;42:433–41.PubMed
55.
Cvetkovic N, Stojanovic E, Stojiljkovic N, Nikolic D, Scanlan AT, Milanovic Z. Exercise training in overweight and obese children: Recreational football and high-intensity interval training provide similar benefits to physical fitness. Scand J Med Sci Sports. 2018;28(Suppl 1):18–32.PubMed
56.
Christensen RH, Wedell-Neergaard AS, Lehrskov LL, Legaard GE, Dorph E, Larsen MK, Launbo N, Fagerlind SR, Seide SK, Nymand S, et al. Effect of aerobic and resistance exercise on cardiac adipose tissues: secondary analyses from a randomized clinical trial. JAMA Cardiol. 2019;4:778–87.PubMedPubMedCentral
57.
Frimpong E, Dafkin C, Donaldson J, Millen AME, Meiring RM. The effect of home-based low-volume, high-intensity interval training on cardiorespiratory fitness, body composition and cardiometabolic health in women of normal body mass and those with overweight or obesity: protocol for a randomized controlled trial. BMC Sports Sci Med Rehabil. 2019;11:39.PubMedPubMedCentral
58.
Wewege M, van den Berg R, Ward RE, Keech A. The effects of high-intensity interval training vs. moderate-intensity continuous training on body composition in overweight and obese adults: a systematic review and meta-analysis. Obes Rev. 2017;18:635–46.PubMed
59.
James PA, Oparil S, Carter BL, Cushman WC, Dennison-Himmelfarb C, Handler J, Lackland DT, LeFevre ML, MacKenzie TD, Ogedegbe O, et al. 2014 Evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8). JAMA. 2014;311:507–20.PubMed
60.
Batacan RB Jr, Duncan MJ, Dalbo VJ, Tucker PS, Fenning AS. Effects of high-intensity interval training on cardiometabolic health: a systematic review and meta-analysis of intervention studies. Br J Sports Med. 2017;51:494–503.PubMed
61.
Liu J, Zhu L, Su Y. Comparative effectiveness of high-intensity interval training and moderate-intensity continuous training for cardiometabolic risk factors and cardiorespiratory fitness in childhood obesity: a meta-analysis of randomized controlled trials. Front Physiol. 2020;11:214.PubMedPubMedCentral
62.
Way KL, Sultana RN, Sabag A, Baker MK, Johnson NA. The effect of high Intensity interval training versus moderate intensity continuous training on arterial stiffness and 24h blood pressure responses: a systematic review and meta-analysis. J Sci Med Sport. 2019;22:385–91.PubMed
63.
Plavsic L, Knezevic OM, Sovtic A, Minic P, Vukovic R, Mazibrada I, Stanojlovic O, Hrncic D, Rasic-Markovic A, Macut D. Effects of high-intensity interval training and nutrition advice on cardiometabolic markers and aerobic fitness in adolescent girls with obesity. Appl Physiol Nutr Metab. 2020;45:294–300.PubMed
64.
Delgado-Floody P, Izquierdo M, Ramirez-Velez R, Caamano-Navarrete F, Moris R, Jerez-Mayorga D, Andrade DC, Alvarez C. Effect of high-intensity interval training on body composition, cardiorespiratory fitness, blood pressure, and substrate utilization during exercise among prehypertensive and hypertensive patients with excessive adiposity. Front Physiol. 2020;11: 558910.PubMedPubMedCentral
65.
Costa EC, Hay JL, Kehler DS, Boreskie KF, Arora RC, Umpierre D, Szwajcer A, Duhamel TA. Effects of high-intensity interval training versus moderate-intensity continuous training on blood pressure in adults with pre- to established hypertension: a systematic review and meta-analysis of randomized trials. Sports Med. 2018;48:2127–42.PubMed
66.
Davis RAH, Halbrooks JE, Watkins EE, Fisher G, Hunter GR, Nagy TR, Plaisance EP. High-intensity interval training and calorie restriction promote remodeling of glucose and lipid metabolism in diet-induced obesity. Am J Physiol Endocrinol Metab. 2017;313:E243–56.PubMedPubMedCentral
67.
68.
Fisher G, Brown AW, Bohan Brown MM, Alcorn A, Noles C, Winwood L, Resuehr H, George B, Jeansonne MM, Allison DB. High intensity interval- vs Moderate intensity—training for improving cardiometabolic health in overweight or obese males: a randomized controlled trial. PLoS ONE. 2015;10: e0138853.PubMedPubMedCentral
69.
Gripp F, Nava RC, Cassilhas RC, Esteves EA, Magalhaes COD, Dias-Peixoto MF, de Castro MF, Amorim FT. HIIT is superior than MICT on cardiometabolic health during training and detraining. Eur J Appl Physiol. 2021;121:159–72.PubMed
70.
Matsuo T, So R, Shimojo N, Tanaka K. Effect of aerobic exercise training followed by a low-calorie diet on metabolic syndrome risk factors in men. Nutr Metab Cardiovasc Dis. 2015;25:832–8.PubMed
71.
da Silva MR, Waclawovsky G, Perin L, Camboim I, Eibel B, Lehnen AM. Effects of high-intensity interval training on endothelial function, lipid profile, body composition and physical fitness in normal-weight and overweight-obese adolescents: a clinical trial. Physiol Behav. 2020;213: 112728.PubMed
72.
Kong Z, Sun S, Liu M, Shi Q. Short-term high-intensity interval training on body composition and blood glucose in overweight and obese young women. J Diabetes Res. 2016;2016:4073618.PubMedPubMedCentral
73.
Sawyer BJ, Tucker WJ, Bhammar DM, Ryder JR, Sweazea KL, Gaesser GA. Effects of high-intensity interval training and moderate-intensity continuous training on endothelial function and cardiometabolic risk markers in obese adults. J Appl Physiol (1985). 2016;121:279–88.
74.
Ramos JS, Dalleck LC, Tjonna AE, Beetham KS, Coombes JS. The impact of high-intensity interval training versus moderate-intensity continuous training on vascular function: a systematic review and meta-analysis. Sports Med. 2015;45:679–92.PubMed
75.
Boutcher SH. High-intensity intermittent exercise and fat loss. J Obes. 2011;2011: 868305.PubMed
Metadata
Title
Effects of high-intensity interval training on improving arterial stiffness in Chinese female university students with normal weight obese: a pilot randomized controlled trial
Authors
Jingyun Hu
Min Liu
Ruoyu Yang
Liyan Wang
Leichao Liang
Yuanyuan Yang
Shihao Jia
Ruiyi Chen
Qianle Liu
Yu Ren
Lei Zhu
Ming Cai
Publication date
01-12-2022
Publisher
BioMed Central
Published in
Journal of Translational Medicine / Issue 1/2022
Electronic ISSN: 1479-5876
DOI
https://doi.org/10.1186/s12967-022-03250-9

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