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Open Access 01-12-2017 | Research

Comparison of three different anti-Xa assays in major orthopedic surgery patients treated with direct oral anticoagulant

Authors: Makoto Ikejiri, Hideo Wada, Shine Tone, Hiroki Wakabayashi, Masahiro Hasegawa, Takeshi Matsumoto, Naoki Fujimoto, Norikazu Yamada, Masaaki Ito, Kaname Nakatani, Akihiro Sudo

Published in: Thrombosis Journal | Issue 1/2017

Abstract

Background

Measurement of edoxaban plasma concentration has been gathering attention in major orthopedic surgery patients receiving edoxaban for the prevention of venous thromboembolism (VTE).

Methods

The anti-Xa activity was measured one hour after edoxaban intake using 3 different assays in 200 patients after major orthopedic surgery.

Results

The anti-Xa activities on Day 8 were significantly higher than those on Day 4 and those on Day 4 were significantly higher than those on Day 1. The anti-Xa activities in two assays closely correlated with each other, but the other anti-Xa assay did not correlated with other two assays. The anti-Xa activities as detected in the three Xa assays were significantly higher in the patients without deep vein thrombosis (DVT) than in those with DVT on Day 4. Additionally, there were no significant differences in the anti-Xa activities of assays A, B and C between patients with and without massive bleeding (MB) on Days 1, 4, 8 and 15.

Conclusion

The results of this study suggest that anti-Xa level could be predictive of the risk of VTE, but not of the risk of massive bleeding.

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Title: Comparison of three different anti-Xa assays in major orthopedic surgery patients treated with direct oral anticoagulant
Authors: Makoto Ikejiri
Hideo Wada
Shine Tone
Hiroki Wakabayashi
Masahiro Hasegawa
Takeshi Matsumoto
Naoki Fujimoto
Norikazu Yamada
Masaaki Ito
Kaname Nakatani
Akihiro Sudo
Publication date: 01-12-2017
Publisher: BioMed Central
Published in: Thrombosis Journal / Issue 1/2017
Electronic ISSN: 1477-9560
DOI: https://doi.org/10.1186/s12959-017-0150-4

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Comparison of three different anti-Xa assays in major orthopedic surgery patients treated with direct oral anticoagulant

Abstract

Background

Methods

Results

Conclusion

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Abstract

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