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Open Access 01-12-2017 | Case report

A case of pulmonary thromboembolism due to coagulation factor V Leiden in Japan ~ usefulness of next generation sequencing~

Authors: Daisuke Sueta, Miwa Ito, Mitsuhiro Uchiba, Kenji Sakamoto, Eiichiro Yamamoto, Yasuhiro Izumiya, Sunao Kojima, Koichi Kaikita, Satoru Shinriki, Seiji Hokimoto, Hirotaka Matsui, Kenichi Tsujita

Published in: Thrombosis Journal | Issue 1/2017

Abstract

Background

Because the venous thromboembolisms (VTEs) due to the coagulation factor V R506Q (FV Leiden) mutation is often seen in Caucasians, the VTE onset in Japan has not been reported.

Case presentation

A 34-year-old man from north Africa experiencing sudden dyspnea went to a hospital for advice.

The patient had pain in his right leg and a high plasma D-dimer level. A contrast-enhanced computed tomography scan revealed a contrast deficit in the bilateral pulmonary artery and in the right lower extremity. The patient was diagnosed with VTE, and anticoagulation therapy was initiated. Our targeted gene panel sequencing revealed that the occurrence of VTE was attributed to a presence of the FV Leiden mutation.

Conclusions

This is the first report demonstrating VTE caused by the FV Leiden mutation in Japan.

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Title: A case of pulmonary thromboembolism due to coagulation factor V Leiden in Japan ~ usefulness of next generation sequencing~
Authors: Daisuke Sueta
Miwa Ito
Mitsuhiro Uchiba
Kenji Sakamoto
Eiichiro Yamamoto
Yasuhiro Izumiya
Sunao Kojima
Koichi Kaikita
Satoru Shinriki
Seiji Hokimoto
Hirotaka Matsui
Kenichi Tsujita
Publication date: 01-12-2017
Publisher: BioMed Central
Published in: Thrombosis Journal / Issue 1/2017
Electronic ISSN: 1477-9560
DOI: https://doi.org/10.1186/s12959-017-0132-6

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A case of pulmonary thromboembolism due to coagulation factor V Leiden in Japan ~ usefulness of next generation sequencing~

Abstract

Background

Case presentation

Conclusions

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Abstract

Background

Case presentation

Conclusions

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