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Published in: Thrombosis Journal 1/2016

Open Access 01-10-2016 | Research

Aspirin plus tirofiban inhibit the thrombosis induced by Russell’s viper venom

Authors: Ren-Chieh Wu, Ping-Tse Chou, Li-Kuang Chen

Published in: Thrombosis Journal | Special Issue 1/2016

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Abstract

Background

Thrombosis and coagulopathy are the commonest hematological manifestations of envenomation of Russell’s viper venom (RVV). Factor X is activated by a factor X-activating enzyme from Russell’s viper venom (RVV-X) to start the coagulation cascade. We established an animal model with local ischemic effects induced by RVV. We tried to treat RVV envenomation with antiplatelets and anticoagulants without recourse to antivenom.

Methods

RVV was injected into the foot pad of mice. We observed the effects at different intervals and compared local changes in ischemia with drug treatment after 30 min.

Results

A combination of aspirin plus tirofiban could prevent the ischemic change induced by RVV. The antithrombotic effects of single-use of aspirin or tirofiban were better than single-use of heparin or clopidogrel.

Conclusion

The aspirin + tirofiban group had a better outcome with respect to prevention of tissue ischemia and gangrene. This indicates that the activation and aggregation of platelets is the major cause of thrombosis induced by RVV.
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Metadata
Title
Aspirin plus tirofiban inhibit the thrombosis induced by Russell’s viper venom
Authors
Ren-Chieh Wu
Ping-Tse Chou
Li-Kuang Chen
Publication date
01-10-2016
Publisher
BioMed Central
Published in
Thrombosis Journal / Issue Special Issue 1/2016
Electronic ISSN: 1477-9560
DOI
https://doi.org/10.1186/s12959-016-0093-1

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