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Reproductive Biology and Endocrinology
Published in: Reproductive Biology and Endocrinology 1/2019

Open Access 01-12-2019 | Estrogens | Review

The role of SCF ubiquitin-ligase complex at the beginning of life

Authors: Jiayan Xie, Yimei Jin, Guang Wang

Published in: Reproductive Biology and Endocrinology | Issue 1/2019

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Abstract

As the largest family of E3 ligases, the Skp1-cullin 1-F-box (SCF) E3 ligase complex is comprised of Cullins, Skp1 and F-box proteins. And the SCF E3 ubiquitin ligases play an important role in regulating critical cellular processes, which promote degradation of many cellular proteins, including signal transducers, cell cycle regulators, and transcription factors. We review the biological roles of the SCF ubiquitin-ligase complex in gametogenesis, oocyte-to-embryo transition, embryo development and the regulation for estrogen and progestin. We find that researches about the SCF ubiquitin-ligase complex at the beginning of life are not comprehensive, thus more in-depth researches will promote its eventual clinical application.
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Metadata
Title
The role of SCF ubiquitin-ligase complex at the beginning of life
Authors
Jiayan Xie
Yimei Jin
Guang Wang
Publication date
01-12-2019
Publisher
BioMed Central
Keyword
Estrogens
Published in
Reproductive Biology and Endocrinology / Issue 1/2019
Electronic ISSN: 1477-7827
DOI
https://doi.org/10.1186/s12958-019-0547-y

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