Skip to main content
Top
Published in: Reproductive Biology and Endocrinology 1/2015

Open Access 01-12-2015 | Short communication

Luteal phase ovarian stimulation following oocyte retrieval: is it helpful for poor responders?

Author: John Zhang

Published in: Reproductive Biology and Endocrinology | Issue 1/2015

Login to get access

Abstract

Background

Poor ovarian response and retrieval of no oocytes following ovarian stimulation for in vitro fertilization (IVF) is a challenging problem for both the patient and the clinician.

Findings

Recent evidence indicates that folliculogenesis occurs in a wave-like fashion indicating that there are multiple follicular recruitment waves in the same menstrual cycle. This relatively new scientific concept provides new opportunities for the utilization of ovarian stimulation in women with poor ovarian response. This communication reports on the social and scientific rationale for the use of luteal phase ovarian stimulation following oocyte retrieval in the same cycle (also called double stimulation).

Conclusions

Data to date showed that double ovarian stimulation in poor responders provides shorter time for retrieving mature oocytes with the potential formation of good quality embryos, and thus healthy pregnancies.
Literature
1.
go back to reference van Loendersloot LL, van Wely M, Repping S, Bossuyt PM, van der Veen F. Individualized decision-making in IVF: calculating the chances of pregnancy. Hum Reprod. 2013;28:2972–80.PubMedCrossRef van Loendersloot LL, van Wely M, Repping S, Bossuyt PM, van der Veen F. Individualized decision-making in IVF: calculating the chances of pregnancy. Hum Reprod. 2013;28:2972–80.PubMedCrossRef
2.
go back to reference Gleicher N, Barad D. “Ovarian age-based” stimulation of young women with diminished ovarian reserve results in excellent pregnancy rates with in vitro fertilization. Fertil Steril. 2006;86:1621–5.PubMedCrossRef Gleicher N, Barad D. “Ovarian age-based” stimulation of young women with diminished ovarian reserve results in excellent pregnancy rates with in vitro fertilization. Fertil Steril. 2006;86:1621–5.PubMedCrossRef
3.
go back to reference Check JH, Brasile D, Choe JK, Amui J, Wilson C. The effect of cetrorelix vs. ganirelix on pregnancy outcome using minimal gonadotropin stimulation in women with elevated day 3 serum follicle stimulating hormone levels. Clin Exp Obstet Gynecol. 2009;36:148–9.PubMed Check JH, Brasile D, Choe JK, Amui J, Wilson C. The effect of cetrorelix vs. ganirelix on pregnancy outcome using minimal gonadotropin stimulation in women with elevated day 3 serum follicle stimulating hormone levels. Clin Exp Obstet Gynecol. 2009;36:148–9.PubMed
4.
go back to reference Lamazou F, Fuchs F, Grynberg M, Gallot V, Herzog E, Fanchin R, et al. Cancellation of IVF-ET cycles: poor prognosis, poor responder, or variability of the response to controlled ovarian hyperstimulation? An analysis of 142 cancellations. J Gynecol Obstet Biol Reprod. 2012;41:41–7.CrossRef Lamazou F, Fuchs F, Grynberg M, Gallot V, Herzog E, Fanchin R, et al. Cancellation of IVF-ET cycles: poor prognosis, poor responder, or variability of the response to controlled ovarian hyperstimulation? An analysis of 142 cancellations. J Gynecol Obstet Biol Reprod. 2012;41:41–7.CrossRef
5.
go back to reference Baerwald AR, Adams GP, Pierson RA. A new model for ovarian follicular development during the human menstrual cycle. Fertil Steril. 2003;80:116–22.PubMedCrossRef Baerwald AR, Adams GP, Pierson RA. A new model for ovarian follicular development during the human menstrual cycle. Fertil Steril. 2003;80:116–22.PubMedCrossRef
6.
go back to reference Baerwald AR, Adams GP, Pierson RA. Characterization of ovarian follicular wave dynamics in women. Biol Reprod. 2003;69:1023–31.PubMedCrossRef Baerwald AR, Adams GP, Pierson RA. Characterization of ovarian follicular wave dynamics in women. Biol Reprod. 2003;69:1023–31.PubMedCrossRef
7.
go back to reference Ben-Shlomo I, Schiff E, Levran D, Ben-Rafael Z, Mashiach S, Dor J. Failure of oocyte retrieval during in vitro fertilization: a sporadic event rather than a syndrome. Fertil Steril. 1991;55:324–7.PubMed Ben-Shlomo I, Schiff E, Levran D, Ben-Rafael Z, Mashiach S, Dor J. Failure of oocyte retrieval during in vitro fertilization: a sporadic event rather than a syndrome. Fertil Steril. 1991;55:324–7.PubMed
8.
go back to reference Beck-Fruchter R, Weiss A, Lavee M, Geslevich Y, Shalev E. Empty follicle syndrome: successful treatment in a recurrent case and review of the literature. Hum Reprod. 2012;27:1357–67.PubMedCrossRef Beck-Fruchter R, Weiss A, Lavee M, Geslevich Y, Shalev E. Empty follicle syndrome: successful treatment in a recurrent case and review of the literature. Hum Reprod. 2012;27:1357–67.PubMedCrossRef
9.
go back to reference Aktas M, Beckers NG, van Inzen WG, Verhoeff A, de Jong D. Oocytes in the empty follicle: a controversial syndrome. Fertil Steril. 2005;84:1643–8.PubMedCrossRef Aktas M, Beckers NG, van Inzen WG, Verhoeff A, de Jong D. Oocytes in the empty follicle: a controversial syndrome. Fertil Steril. 2005;84:1643–8.PubMedCrossRef
10.
go back to reference Bustillo M. Unsuccessful oocyte retrieval: technical artefact or genuine ‘empty follicle syndrome’? Reprod Biomed Online. 2004;8:59–67.PubMedCrossRef Bustillo M. Unsuccessful oocyte retrieval: technical artefact or genuine ‘empty follicle syndrome’? Reprod Biomed Online. 2004;8:59–67.PubMedCrossRef
11.
go back to reference Reichman DE, Hornstein MD, Jackson KV, Racowsky C. Empty follicle syndrome--does repeat administration of hCG really work? Fertil Steril. 2010;94:375–7.PubMedCrossRef Reichman DE, Hornstein MD, Jackson KV, Racowsky C. Empty follicle syndrome--does repeat administration of hCG really work? Fertil Steril. 2010;94:375–7.PubMedCrossRef
12.
go back to reference Baerwald AR, Adams GP, Pierson RA. Ovarian antral folliculogenesis during the human menstrual cycle: a review. Hum Reprod Update. 2012;18:73–91.PubMedCrossRef Baerwald AR, Adams GP, Pierson RA. Ovarian antral folliculogenesis during the human menstrual cycle: a review. Hum Reprod Update. 2012;18:73–91.PubMedCrossRef
13.
go back to reference Hillier SG. Current concepts of the roles of follicle stimulating hormone and luteinizing hormone in folliculogenesis. Hum Reprod. 1994;9:188–91.PubMed Hillier SG. Current concepts of the roles of follicle stimulating hormone and luteinizing hormone in folliculogenesis. Hum Reprod. 1994;9:188–91.PubMed
14.
go back to reference Yang DZ, Yang W, Li Y, He Z. Progress in understanding human ovarian folliculogenesis and its implications in assisted reproduction. J Assist Reprod Genet. 2013;30:213–9.PubMedCentralPubMedCrossRef Yang DZ, Yang W, Li Y, He Z. Progress in understanding human ovarian folliculogenesis and its implications in assisted reproduction. J Assist Reprod Genet. 2013;30:213–9.PubMedCentralPubMedCrossRef
15.
go back to reference de Mello Bianchi PH, Serafini P, Monteiro da Rocha A, Assad Hassun P, Alves da Motta EL, Sampaio Baruselli P, et al. Review: follicular waves in the human ovary: a new physiological paradigm for novel ovarian stimulation protocols. Reprod Sci. 2010;17:1067–76.PubMedCrossRef de Mello Bianchi PH, Serafini P, Monteiro da Rocha A, Assad Hassun P, Alves da Motta EL, Sampaio Baruselli P, et al. Review: follicular waves in the human ovary: a new physiological paradigm for novel ovarian stimulation protocols. Reprod Sci. 2010;17:1067–76.PubMedCrossRef
16.
go back to reference Kuang Y, Chen Q, Hong Q, Lyu Q, Ai A, Fu Y, et al. Double stimulations during the follicular and luteal phases of poor responders in IVF/ICSI programmes (Shanghai protocol). Reprod Biomed Online. 2014;29:684–91.PubMedCrossRef Kuang Y, Chen Q, Hong Q, Lyu Q, Ai A, Fu Y, et al. Double stimulations during the follicular and luteal phases of poor responders in IVF/ICSI programmes (Shanghai protocol). Reprod Biomed Online. 2014;29:684–91.PubMedCrossRef
17.
go back to reference Takasaki A, Tamura H, Taketani T, Shimamura K, Morioka H, Sugino N. A pilot study to prevent a thin endometrium in patients undergoing clomiphene citrate treatment. J Ovarian Res. 2013;6:94.PubMedCentralPubMedCrossRef Takasaki A, Tamura H, Taketani T, Shimamura K, Morioka H, Sugino N. A pilot study to prevent a thin endometrium in patients undergoing clomiphene citrate treatment. J Ovarian Res. 2013;6:94.PubMedCentralPubMedCrossRef
18.
go back to reference Reynolds K, Khoury J, Sosnowski J, Thie J, Hofmann G. Comparison of the effect of tamoxifen on endometrial thickness in women with thin endometrium (<7 mm) undergoing ovulation induction with clomiphene citrate. Fertil Steril. 2010;93:2091–3.PubMedCrossRef Reynolds K, Khoury J, Sosnowski J, Thie J, Hofmann G. Comparison of the effect of tamoxifen on endometrial thickness in women with thin endometrium (<7 mm) undergoing ovulation induction with clomiphene citrate. Fertil Steril. 2010;93:2091–3.PubMedCrossRef
19.
go back to reference Kato K, Takehara Y, Segawa T, Kawachiya S, Okuno T, Kobayashi T, et al. Minimal ovarian stimulation combined with elective single embryo transfer policy: age-specific results of a large, single-centre, Japanese cohort. Reprod Biol Endocrinol. 2012;10:35.PubMedCentralPubMedCrossRef Kato K, Takehara Y, Segawa T, Kawachiya S, Okuno T, Kobayashi T, et al. Minimal ovarian stimulation combined with elective single embryo transfer policy: age-specific results of a large, single-centre, Japanese cohort. Reprod Biol Endocrinol. 2012;10:35.PubMedCentralPubMedCrossRef
20.
go back to reference Rombauts L, Suikkari AM, MacLachlan V, Trounson AO, Healy DL. Recruitment of follicles by recombinant human follicle-stimulating hormone commencing in the luteal phase of the ovarian cycle. Fertil Steril. 1998;69:665–9.PubMedCrossRef Rombauts L, Suikkari AM, MacLachlan V, Trounson AO, Healy DL. Recruitment of follicles by recombinant human follicle-stimulating hormone commencing in the luteal phase of the ovarian cycle. Fertil Steril. 1998;69:665–9.PubMedCrossRef
21.
go back to reference Kansal Kalra S, Ratcliffe S, Gracia CR, Martino L, Coutifaris C, Barnhart KT. Randomized controlled pilot trial of luteal phase recombinant FSH stimulation in poor responders. Reprod Biomed Online. 2008;17:745–50.PubMedCrossRef Kansal Kalra S, Ratcliffe S, Gracia CR, Martino L, Coutifaris C, Barnhart KT. Randomized controlled pilot trial of luteal phase recombinant FSH stimulation in poor responders. Reprod Biomed Online. 2008;17:745–50.PubMedCrossRef
Metadata
Title
Luteal phase ovarian stimulation following oocyte retrieval: is it helpful for poor responders?
Author
John Zhang
Publication date
01-12-2015
Publisher
BioMed Central
Published in
Reproductive Biology and Endocrinology / Issue 1/2015
Electronic ISSN: 1477-7827
DOI
https://doi.org/10.1186/s12958-015-0076-2

Other articles of this Issue 1/2015

Reproductive Biology and Endocrinology 1/2015 Go to the issue