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Open Access 01-12-2018 | Research

Multimodal treatment of pediatric patients with Askin’s tumors: our experience

Authors: Silvia Triarico, Giorgio Attinà, Palma Maurizi, Stefano Mastrangelo, Lorenzo Nanni, Vito Briganti, Elisa Meacci, Stefano Margaritora, Mario Balducci, Antonio Ruggiero

Published in: World Journal of Surgical Oncology | Issue 1/2018

Abstract

Background

We report our experience and outcomes about the management of Askin’s tumors [AT], which are rare primitive neuroectodermal tumors (PNETs) that develop within the soft tissue of the thoracopulmonary region, typically in children and adolescents.

Methods

We retrospectively analyzed the charts of 9 patients affected by AT (aged 6–15 years), treated at the Paediatric Oncology Unit of Gemelli University Hospital in Rome between January 2001 and December 2016.

Results

All nine patients underwent to biopsy followed by neoadjuvant chemotherapy. At the end of the neoadjuvant chemotherapy, they underwent to surgical removal of the residual tumor. Five patients with positive tumor margins and/or necrosis< 90% received local radiotherapy. Two patients with metastasis received an intensified treatment, with the addition of high dose adjuvant chemotherapy followed by peripheral blood stem cells rescue. No statistically significant correlation was found between outcome and gender; the presence of any metastasis and the radiotherapy. The overall survival was 65.14 months (95% confidence interval [95%CI], 45.81–84.48), and the 5 years survival was 60%, at a median follow-up of 53.1 months.

Conclusion

Our study confirms that a multimodal treatment with surgery, chemotherapy, and radiotherapy may increase the survival in AT pediatric patients.

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Title: Multimodal treatment of pediatric patients with Askin’s tumors: our experience
Authors: Silvia Triarico
Giorgio Attinà
Palma Maurizi
Stefano Mastrangelo
Lorenzo Nanni
Vito Briganti
Elisa Meacci
Stefano Margaritora
Mario Balducci
Antonio Ruggiero
Publication date: 01-12-2018
Publisher: BioMed Central
Published in: World Journal of Surgical Oncology / Issue 1/2018
Electronic ISSN: 1477-7819
DOI: https://doi.org/10.1186/s12957-018-1434-2

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Multimodal treatment of pediatric patients with Askin’s tumors: our experience

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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