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World Journal of Surgical Oncology
Published in: World Journal of Surgical Oncology 1/2017

Open Access 01-12-2017 | Review

Extracranial metastases of high-grade glioma: the clinical characteristics and mechanism

Authors: Qian Sun, Rui Xu, Hongbo Xu, Gengming Wang, Xueming Shen, Hao Jiang

Published in: World Journal of Surgical Oncology | Issue 1/2017

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Abstract

Background

This presentation of two cases and literature review discusses the epidemiology, clinical manifestations, pathogenesis, diagnosis, treatment, and prognosis of high-grade glioma with extracranial metastases.

Methods

A retrospective analysis of the clinical features of two cases of malignant glioma, including metastatic sites, pathological data, and treatment methods, and a literature review was performed.

Results

Two patients developed extracranial metastases within 1 year after surgery for primary glioma. One patient developed cervical lymph node and bone metastases while the other developed bone metastases, and both patients died within 2 months after the diagnosis of the extracranial metastasis.

Conclusion

Extracranial metastases may develop from malignant gliomas. According to the literature, the most common extracranial site is intraspinal (along the neural axis), followed by the vertebrae, lungs, liver, and lymph nodes. The complex metastatic mechanism remains unclear, and the prognosis is very poor, with a survival duration of less than 6 months.
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Metadata
Title
Extracranial metastases of high-grade glioma: the clinical characteristics and mechanism
Authors
Qian Sun
Rui Xu
Hongbo Xu
Gengming Wang
Xueming Shen
Hao Jiang
Publication date
01-12-2017
Publisher
BioMed Central
Published in
World Journal of Surgical Oncology / Issue 1/2017
Electronic ISSN: 1477-7819
DOI
https://doi.org/10.1186/s12957-017-1249-6

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