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World Journal of Surgical Oncology

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Open Access 01-12-2017 | Research

Exploring the FGFR3-related oncogenic mechanism in bladder cancer using bioinformatics strategy

Authors: Wei Cao, Enguang Ma, Li Zhou, Tan Yuan, Chunying Zhang

Published in: World Journal of Surgical Oncology | Issue 1/2017

Abstract

Background

Aberrant activation of fibroblast growth factor receptor 3 (FGFR3) is frequently observed in bladder cancer, but how it involved in carcinogenesis is not well understood. The current study was aimed to investigate the underlying mechanism on the progression of bladder cancer.

Methods

The GSE41035 dataset downloaded from Gene Expression Omnibus was used to identify the differentially expressed genes (DEGs) between bladder cancer cell line RT112 with or without depletion of FGFR3, and gene ontology enrichment analysis was performed. Then, FGFR3-centered protein–protein interaction (PPI) and regulatory networks were constructed. Combined with the data retrieved from GSE31684, prognostic makers for bladder cancer were predicted.

Results

We identified a total of 2855 DEGs, and most of them were associated with blood vessel morphogenesis and cell division. In addition, KIAA1377, POLA2, FGFR3, and EPHA4 were the hub genes with high degree in the FGFR3-centered PPI network. Besides, 17 microRNAs (miRNAs) and 6 transcriptional factors (TFs) were predicted to be the regulators of the nodes in PPI network. Moreover, CSTF2, POLA1, HMOX2, and EFNB2 may be associated with the prognosis of bladder cancer patient.

Conclusions

The current study may provide some insights into the molecular mechanism of FGFR3 as a mediator in bladder cancer.

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Title: Exploring the FGFR3-related oncogenic mechanism in bladder cancer using bioinformatics strategy
Authors: Wei Cao
Enguang Ma
Li Zhou
Tan Yuan
Chunying Zhang
Publication date: 01-12-2017
Publisher: BioMed Central
Published in: World Journal of Surgical Oncology / Issue 1/2017
Electronic ISSN: 1477-7819
DOI: https://doi.org/10.1186/s12957-017-1125-4

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Exploring the FGFR3-related oncogenic mechanism in bladder cancer using bioinformatics strategy

Abstract

Background

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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