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Open Access 01-12-2017 | Research

The stratification of patient risk depending on the size and ratio of metastatic lymph nodes in papillary thyroid carcinoma

Authors: Young Ran Hong, So Hee Lee, Dong Jun Lim, Min Hee Kim, Chan Kwon Jung, Byung Joo Chae, Byung Joo Song, Ja Seong Bae

Published in: World Journal of Surgical Oncology | Issue 1/2017

Abstract

Background

The aims of this study were to identify the clinical significances of the size of metastatic lymph node (mLN) and LN ratio (LNR) and to attempt to create a risk stratification for papillary thyroid carcinoma (PTC) patients.

Methods

We investigated the 435 PTC patients who underwent radioactive iodine (RAI) ablation treatment following thyroid surgery. The patients were classified into two groups (micrometastasis (pN1mic) ≤ 0.2 cm and macrometastasis (pN1mac) > 0.2 cm) and were stratified into the following three risk groups: group I (pN1mic, LNR ≤ 0.5); group II (pN1mic, LNR > 0.5 or pN1mac, LNR ≤ 0.5); and group III (pN1mac with LNR > 0.5). And then we investigated the association of the classified groups and variable clinicopathologic factors.

Results

The clinical characteristics such as large tumor size, extrathyroidal extension, higher T stage, and greater number of mLN or LNR were significantly associated with pN1mac. The mean stimulated thyroglobulin levels were increased with the patient risk groups (p = 0.02). The recurrence-free survivals were significantly different between the stratified groups (p = 0.001).

Conclusions

The patient groups I, II, and III may be referred to as low-, intermediate-, and high-risk groups. Clinicians should consider the possibility of recurrence, and the decisions about the application of RAI ablation based on the size of mLN and the patient’s risk groups.

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Title: The stratification of patient risk depending on the size and ratio of metastatic lymph nodes in papillary thyroid carcinoma
Authors: Young Ran Hong
So Hee Lee
Dong Jun Lim
Min Hee Kim
Chan Kwon Jung
Byung Joo Chae
Byung Joo Song
Ja Seong Bae
Publication date: 01-12-2017
Publisher: BioMed Central
Published in: World Journal of Surgical Oncology / Issue 1/2017
Electronic ISSN: 1477-7819
DOI: https://doi.org/10.1186/s12957-017-1141-4

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

The stratification of patient risk depending on the size and ratio of metastatic lymph nodes in papillary thyroid carcinoma

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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