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World Journal of Surgical Oncology

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Open Access 01-12-2017 | Research

Is neuroendocrine differentiation a prognostic factor in poorly differentiated colorectal cancer?

Authors: Yue Chen, Fang Liu, Qingkai Meng, Siping Ma

Published in: World Journal of Surgical Oncology | Issue 1/2017

Abstract

Background

To determine the prognostic relevance of neuroendocrine differentiation in poorly differentiated colorectal cancer.

Methods

The clinicopathological features and survival of 70 patients with poorly differentiated colorectal cancer were analyzed retrospectively. Chromogranin A and synaptophysin were used as neuroendocrine markers. Patients were followed-up for more than 3 years or until death.

Results

Of these 70 patients, 36 showed neuroendocrine differentiation. In univariate prognostic analysis, the patients with lymph node metastasis (P < 0.001), advanced TNM stage (P < 0.001), and neuroendocrine differentiation (P = 0.003) tended to have a poor prognosis. However, only lymph node metastasis was associated with a poor prognosis in multivariate analysis (P < 0.001). Patients with neuroendocrine differentiation were associated with lymph node metastasis (P = 0.006).

Conclusions

Neuroendocrine differentiation in poorly differentiated colorectal cancer was not a direct prognostic factor in these patients. Lymph node metastasis was a direct prognostic factor in these patients. Patients with neuroendocrine differentiation were associated with lymph node metastasis.

Mori M, Mimori K, Kamakura T, Adachi Y, Ikeda Y, Sugimachi K. Chromogranin positive cells in colorectal carcinoma and transitional mucosa. J Clin Pathol. 1995;48:754–8.CrossRefPubMedPubMedCentral

Lloyd RV, Schroeder G, Bauman MD, Krook JE, Jin L, Goldberg RM, et al. Prevalence and prognostic significance of neuroendocrine differentiation in colorectal carcinomas. Endocr Pathol. 1998;9:35–42.CrossRefPubMed

Bernick PE, Klimstra DS, Shia J, Minsky B, Saltz L, Shi W, et al. Neuroendocrine carcinomas of the colon and rectum. Dis Colon Rectum. 2004;47:163–9.CrossRefPubMed

Zeng YJ, Lai W, Liu L, Wu H, Luo XX, Wang J, et al. Prognostic significance of neuroendocrine differentiation in colorectal adenocarcinoma after radical operation: a meta-analysis. J Gastrointest Surg. 2014;18:968–76.CrossRefPubMed

Shinji S, Naito Z, Ishiwata T, Tanaka N, Furukawa K, Suzuki H, et al. Neuroendocrine cell differentiation of poorly differentiated colorectal adenocarcinoma correlates with liver metastasis. Int J Oncol. 2006;29:357–64.PubMed

Taniyama K, Suzuki H, Matsumoto M, Hakamada K, Toyama K, Tahara E. Flow cytometric DNA analysis of poorly differentiated adenocarcinoma of the colorectum. Jpn J Clin Oncol. 1991;21:406–11.PubMed

Cass AW, Million RR, Pfaff WW. Patterns of recurrence following surgery alone for adenocarcinoma of the colon and rectum. Cancer. 1976;37:2861–5.CrossRefPubMed

Copeland EM, Miller LD, Jones RS. Prognostic factors in carcinoma of the colon and rectum. Am J Surg. 1968;116:875–81.CrossRefPubMed

Chung CK, Zaino RJ, Stryker JA. Colorectal carcinoma: evaluation of histologic grade and factors influencing prognosis. J Surg Oncol. 1982;21:143–8.CrossRefPubMed

10.

Grabowski P, Schonfelder J, Ahnert-Hilger G, Foss HD, Heine B, Schindler I, et al. Expression of neuroendocrine markers: a signature of human undifferentiated carcinoma of the colon and rectum. Virchows Arch. 2002;441:256–63.CrossRefPubMed

11.

Wiedenmann B, Franke WW, Kuhn C, Moll R, Gould VE. Synaptophysin: a marker protein for neuroendocrine cells and neoplasms. Proc Natl Acad Sci U S A. 1986;83:3500–4.CrossRefPubMedPubMedCentral

12.

Liu Y, Xu J, Jiao Y, Hu Y, Yi C, Li Q, et al. Neuroendocrine differentiation is a prognostic factor for stage II poorly differentiated colorectal cancer. Biomed Res Int. 2014; doi:10.1155/2014/789575.

13.

Hamada Y, Oishi A, Shoji T, Takada H, Yamamura M, Hioki K, et al. Endocrine cells and prognosis in patients with colorectal carcinoma. Cancer. 1992;69:2641–6.CrossRefPubMed

14.

de Bruine AP, Wiggers T, Beek C, Volovics A, von MM, Arends JW, et al. Endocrine cells in colorectal adenocarcinomas: incidence, hormone profile and prognostic relevance. Int J Cancer. 1993;54:765–71.CrossRefPubMed

15.

Vortmeyer AO, Lubensky IA, Merino MJ, Wang CY, Pham T, Furth EE, et al. Concordance of genetic alterations in poorly differentiated colorectal neuroendocrine carcinomas and associated adenocarcinomas. J Natl Cancer Inst. 1997;89:1448–53.CrossRefPubMed

16.

Kim CH, Huh JW, Kim HR, Kim YJ. Prognostic comparison between number and distribution of lymph node metastases in patients with right-sided colon cancer. Ann Surg Oncol. 2014;21:1361–8.CrossRefPubMed

17.

Le VTE, Sigurdson ER, Hanlon AL, Mayer RJ, Macdonald JS, Catalano PJ, et al. Colon cancer survival is associated with increasing number of lymph nodes analyzed: a secondary survey of intergroup trial INT-0089. J Clin Oncol. 2003;21:2912–9.CrossRef

18.

Yasuda K, Adachi Y, Shiraishi N, Yamaguchi K, Hirabayashi Y, Kitano S. Pattern of lymph node micrometastasis and prognosis of patients with colorectal cancer. Ann Surg Oncol. 2001;8:300–4.CrossRefPubMed

19.

Gunderson LL, Sargent DJ, Tepper JE, Wolmark N, O'Connell MJ, Begovic M, et al. Impact of T and N stage and treatment on survival and relapse in adjuvant rectal cancer: a pooled analysis. J Clin Oncol. 2004;22:1785–96.CrossRefPubMed

20.

Johnson LR. Regulation of gastrointestinal mucosal growth. Physiol Rev. 1988;68:456–502.PubMed

21.

Eschrich S, Yang I, Bloom G, Kwong KY, Boulware D, Cantor A, et al. Molecular staging for survival prediction of colorectal cancer patients. J Clin Oncol. 2005;23:3526–35.CrossRefPubMed

22.

Graziano SL, Mazid R, Newman N, Tatum A, Oler A, Mortimer JA, et al. The use of neuroendocrine immunoperoxidase markers to predict chemotherapy response in patients with non-small-cell lung cancer. J Clin Oncol. 1989;7:1398–406.CrossRefPubMed

23.

Carney DN, Mitchell JB, Kinsella TJ. In vitro radiation and chemotherapy sensitivity of established cell lines of human small cell lung cancer and its large cell morphological variants. Cancer Res. 1983;43:2806–11.PubMed

24.

Park JG, Oie HK, Sugarbaker PH, Henslee JG, Chen TR, Johnson BE, et al. Characteristics of cell lines established from human colorectal carcinoma. Cancer Res. 1987;47:6710–8.PubMed

Title: Is neuroendocrine differentiation a prognostic factor in poorly differentiated colorectal cancer?
Authors: Yue Chen
Fang Liu
Qingkai Meng
Siping Ma
Publication date: 01-12-2017
Publisher: BioMed Central
Published in: World Journal of Surgical Oncology / Issue 1/2017
Electronic ISSN: 1477-7819
DOI: https://doi.org/10.1186/s12957-017-1139-y

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Is neuroendocrine differentiation a prognostic factor in poorly differentiated colorectal cancer?

Abstract

Background

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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