Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on sleep in brain health

LIVE: Thursday 2nd May 2024, 18:00-19:30 (CEST)

Quality sleep is essential for health. But what happens to our brains when sleep patterns are disturbed? Join our experts to explore the interplay between sleep disruption and neurological diseases, and the questions that you need to be asking your patients to help you prevent the harmful effects of sleep deprivation.
ADVANCED SEARCH
Log in
Top
World Journal of Surgical Oncology
Published in: World Journal of Surgical Oncology 1/2017

Open Access 01-12-2017 | Case report

Pulmonary toxicity after intraperitoneal mitomycin C: a case report of a rare complication of HIPEC

Authors: Melissa L. Abel, George Kokosis, Dan G. Blazer

Published in: World Journal of Surgical Oncology | Issue 1/2017

Login to get access

Abstract

Background

Cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) has become a common treatment approach for disseminated appendiceal neoplasms. Systemic absorption of intraperitoneal chemotherapeutics may lead to drug-induced toxicity, most commonly neutropenia. Mitomycin C has been the most commonly used chemotherapeutic in HIPEC for the past several decades.

Case presentation

Here, we describe a rare pulmonary complication secondary to intraperitoneal administration of mitomycin C.

Conclusions

While rare, intraperitoneal mitomycin C has the potential to cause serious pulmonary toxicity that should be considered with administration. To our knowledge, this report represents only the second case described in the literature.
Literature
1.
Lambert LA. Looking up: recent advances in understanding and treating peritoneal carcinomatosis. CA Cancer J Clin. 2015;65(4):284–98.CrossRefPubMed
2.
Sugarbaker PH, Jablonski KA. Prognostic features of 51 colorectal and 130 appendiceal cancer patients with peritoneal carcinomatosis treated by cytoreductive surgery and intraperitoneal chemotherapy. Ann Surg. 1995;221(2):124–32.CrossRefPubMedPubMedCentral
3.
Gonzalez-Moreno S. Peritoneal Surface Oncology: a progress report. Eur J Surg Oncol. 2006;32(6):593–6.CrossRefPubMed
4.
Stephens AD, et al. Morbidity and mortality analysis of 200 treatments with cytoreductive surgery and hyperthermic intraoperative intraperitoneal chemotherapy using the coliseum technique. Ann Surg Oncol. 1999;6(8):790–6.CrossRefPubMed
5.
Stewart JH, et al. Appendiceal neoplasms with peritoneal dissemination: outcomes after cytoreductive surgery and intraperitoneal hyperthermic chemotherapy. Ann Surg Oncol. 2006;13(5):624–34.CrossRefPubMed
6.
Yan TD, et al. A systematic review and meta-analysis of the randomized controlled trials on adjuvant intraperitoneal chemotherapy for resectable gastric cancer. Ann Surg Oncol. 2007;14(10):2702–13.CrossRefPubMed
7.
Katz MH, Barone RM. The rationale of perioperative intraperitoneal chemotherapy in the treatment of peritoneal surface malignancies. Surg Oncol Clin N Am. 2003;12(3):673–88.CrossRefPubMed
8.
Kuzuya T, et al. Pharmacokinetic characteristics of 5-fluorouracil and mitomycin C in intraperitoneal chemotherapy. J Pharm Pharmacol. 1994;46(8):685–9.CrossRefPubMed
9.
Lambert LA, et al. Incidence, risk factors, and impact of severe neutropenia after hyperthermic intraperitoneal mitomycin C. Ann Surg Oncol. 2009;16(8):2181–7.CrossRefPubMedPubMedCentral
10.
Kemmel V, et al. Mitomycin C pharmacokinetics as predictor of severe neutropenia in hyperthermic intraperitoneal therapy. Ann Surg Oncol. 2015;22 Suppl 3:873–9.CrossRef
11.
Twohig KJ, Matthay RA. Pulmonary effects of cytotoxic agents other than bleomycin. Clin Chest Med. 1990;11(1):31–54.PubMed
12.
Saif MW, Dai T. Mitomycin-induced interstitial pneumonitis in a patient with BRCA2 associated metastatic pancreatic carcinoma. JOP. 2010;11(3):277–9.PubMed
13.
Gonzalez-Moreno S, Lambert LA, Mansfield PF. Interstitial pneumonitis: an exceptional toxicity of hyperthermic intraperitoneal mitomycin C. Eur J Surg Oncol. 2008;34(4):482–4.CrossRefPubMed
14.
van Ruth S, Verwaal VJ, Zoetmulder FA. Pharmacokinetics of intraperitoneal mitomycin C. Surg Oncol Clin N Am. 2003;12(3):771–80.CrossRefPubMed
15.
Institute NC. Common terminology criteria for adverse events v4.0. NCI, NIH, DHHS.
16.
Orwoll ES, Kiessling PJ, Patterson JR. Interstitial pneumonia from mitomycin. Ann Intern Med. 1978;89(3):352–5.CrossRefPubMed
17.
Thompson CC, et al. Postoperative pulmonary toxicity associated with mitomycin-C therapy. South Med J. 1992;85(12):1257–9.CrossRefPubMed
18.
Verweij J, et al. Prospective study on the dose relationship of mitomycin C-induced interstitial pneumonitis. Cancer. 1987;60(4):756–61.CrossRefPubMed
Metadata
Title
Pulmonary toxicity after intraperitoneal mitomycin C: a case report of a rare complication of HIPEC
Authors
Melissa L. Abel
George Kokosis
Dan G. Blazer
Publication date
01-12-2017
Publisher
BioMed Central
Published in
World Journal of Surgical Oncology / Issue 1/2017
Electronic ISSN: 1477-7819
DOI
https://doi.org/10.1186/s12957-016-1047-6

Other articles of this Issue 1/2017

World Journal of Surgical Oncology 1/2017 Go to the issue

Review

Influence of enhanced recovery after surgery programs on laparoscopy-assisted gastrectomy for gastric cancer: a systematic review and meta-analysis of randomized control trials

Review

Extracranial metastases of high-grade glioma: the clinical characteristics and mechanism

Case Report

Surgical treatment for mediastinal abscess induced by endobronchial ultrasound-guided transbronchial needle aspiration: a case report and literature review

Research

New trend in colorectal cancer in Germany: are young patients at increased risk for advanced colorectal cancer?

Research

The predictive value of methylene blue dye as a single technique in breast cancer sentinel node biopsy: a study from Dharmais Cancer Hospital

Research

Role of pelvic and para-aortic lymphadenectomy in abandoned radical hysterectomy in cervical cancer