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World Journal of Surgical Oncology

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Open Access 01-12-2016 | Research

Impact of prognostic nutritional index on long-term outcomes in patients with breast cancer

Authors: Tomomi Mohri, Yasuhiko Mohri, Tsunehiko Shigemori, Kenji Takeuchi, Yoshiyuki Itoh, Toshio Kato

Published in: World Journal of Surgical Oncology | Issue 1/2016

Abstract

Background

Prognostic nutritional index has been shown to be a prognostic marker for various solid tumors. However, few studies have investigated the impact of the prognostic nutritional index on survival of patients with breast cancer. The aim of this study was to investigate the impact of the prognostic nutritional index on the long-term outcomes in patients with breast cancer.

Methods

This study reviewed the medical records of 212 patients with breast cancer who underwent mastectomy. The prognostic nutritional index was calculated as 10 × serum albumin (g/dl) + 0.005 × total lymphocyte count (per mm³). Receiver operating characteristic curve analysis was performed to determine the cutoff value of the prognostic nutritional index. The survival curves were calculated by the Kaplan–Meier method. Differences between the curves were analyzed by the log-rank test. Multivariate Cox proportional hazard model was used to evaluate the prognostic significance of prognostic nutritional index in patients with breast cancer.

Results

The mean prognostic nutritional index just before the operation was 51.9, and the median follow-up after surgery was 47.7 months. The optimal cutoff value of the prognostic nutritional index for predicting the overall survival was 52.8 from the receiver operating characteristic curve analysis. The 5-year overall survival rate was 98.3 % in the prognostic nutritional index >52.8 and 92.0 % in the prognostic nutritional index <52.8 (P = 0.013). In the multivariate analysis, a low prognostic nutritional index was an independent predictor for poor overall survival (HR, 5.88; 95 % CI, 1.13–108.01; P = 0.033).

Conclusions

The prognostic nutritional index is a simple and useful marker for predicting the long-term outcomes of breast cancer patients, independent of the tumor stage.

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Title: Impact of prognostic nutritional index on long-term outcomes in patients with breast cancer
Authors: Tomomi Mohri
Yasuhiko Mohri
Tsunehiko Shigemori
Kenji Takeuchi
Yoshiyuki Itoh
Toshio Kato
Publication date: 01-12-2016
Publisher: BioMed Central
Published in: World Journal of Surgical Oncology / Issue 1/2016
Electronic ISSN: 1477-7819
DOI: https://doi.org/10.1186/s12957-016-0920-7

At a glance: The STEP trials

Springer Medicine

Impact of prognostic nutritional index on long-term outcomes in patients with breast cancer

Abstract

Background

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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