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World Journal of Surgical Oncology
Published in: World Journal of Surgical Oncology 1/2016

Open Access 01-12-2016 | Review

The SphKs/S1P/S1PR1 axis in immunity and cancer: more ore to be mined

Authors: Lei Jin, Wei-Ren Liu, Meng-Xin Tian, Jia Fan, Ying-Hong Shi

Published in: World Journal of Surgical Oncology | Issue 1/2016

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Abstract

Over the past two decades, huge amounts of research were launched to understand the functions of sphingosine. Many pathways were uncovered that convey the relative functions of biomacromolecules. In this review, we discuss the recent advances of the role of the SphKs/S1P/S1PR1 axis in immunity and cancer. Finally, we investigate the therapeutic potential of new drugs that target S1P signaling in cancer therapy.
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Metadata
Title
The SphKs/S1P/S1PR1 axis in immunity and cancer: more ore to be mined
Authors
Lei Jin
Wei-Ren Liu
Meng-Xin Tian
Jia Fan
Ying-Hong Shi
Publication date
01-12-2016
Publisher
BioMed Central
Published in
World Journal of Surgical Oncology / Issue 1/2016
Electronic ISSN: 1477-7819
DOI
https://doi.org/10.1186/s12957-016-0884-7

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