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World Journal of Surgical Oncology
Published in: World Journal of Surgical Oncology 1/2015

Open Access 01-12-2015 | Research

The clinical prognosis of patients with cN0 papillary thyroid microcarcinoma by central neck dissection

Authors: Liyang Zhang, Ziwen Liu, Yuewu Liu, Weisheng Gao, Chaoji Zheng

Published in: World Journal of Surgical Oncology | Issue 1/2015

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Abstract

Background

Central lymph node metastasis of papillary thyroid microcarcinoma (PTMC) is common; however, prophylactic central lymph node dissection (CLND) is still controversial because of the possible increased morbidity. The purpose of this study is to determine the clinical outcome of patients with cN0 PTMC by central neck dissection.

Methods

A retrospective cohort study was conducted on patients with PTMC without preoperative evidence of lymph node disease (cN0), and the outcomes were compared between patients undergoing total thyroidectomy (TT) alone (group A) and patients undergoing TT with CLND (group B).

Results

In this study, 242 patients with cN0 PTMC were included. Group A had 108 patients and group B had 134 patients. During a follow-up of over 60 months, the long-term postoperative complications were equivalent between the two groups. In group B, the presence of involved central neck lymph nodes upstaged 16% of patients to stage III disease, which necessitated additional postoperative radioactive iodine treatment. More patients had recurrences in group A. The rate of reoperation in the central compartment was higher in group A than in group B (8.3% vs 2.2%, P < 0.01).

Conclusions

Prophylactic CLND does not increase long-term postoperative complications and reduces the risk of recurrence in the central compartment.
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Metadata
Title
The clinical prognosis of patients with cN0 papillary thyroid microcarcinoma by central neck dissection
Authors
Liyang Zhang
Ziwen Liu
Yuewu Liu
Weisheng Gao
Chaoji Zheng
Publication date
01-12-2015
Publisher
BioMed Central
Published in
World Journal of Surgical Oncology / Issue 1/2015
Electronic ISSN: 1477-7819
DOI
https://doi.org/10.1186/s12957-015-0553-2

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