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Published in: World Journal of Surgical Oncology 1/2015

Open Access 01-12-2015 | Research

Port type is a possible risk factor for implantable venous access port-related bloodstream infections and no sign of local infection predicts the growth of gram-negative bacilli

Authors: Jui-Feng Hsu, Hsu-Liang Chang, Ming-Ju Tsai, Ying-Ming Tsai, Yen-Lung Lee, Pei-Huan Chen, Wen-Chieh Fan, Yu-Chung Su, Chih-Jen Yang

Published in: World Journal of Surgical Oncology | Issue 1/2015

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Abstract

Background

Implantable venous access port (IVAP)-related blood stream infections (BSIs) are one of the most common complications of implantable venous ports. The risk factors and pathogens for IVAP-related BSIs are still controversial.

Methods

We retrospectively reviewed all patients who received IVAPs at a Hospital in Taiwan from January 1, 2011 to June 31, 2014. Two types of venous port, BardPort® 6.6 fr (Bard port) and Autosuture Chemosite® 7.5 fr (TYCO port) were used. All patients with clinically proven venous port-related BSIs were enrolled.

Results

A total of 552 patients were enrolled. There were 34 episodes of IVAP-related BSIs during the study period for a total incidence of 0.177 events/1000 catheter days. Port type (TYCO vs. Bard, HR = 7.105 (95 % confidence interval (CI), 1.688–29.904), p = 0.0075), age > 65 years (HR = 2.320 (95 % CI, 1.179–4.564), p = 0.0148), and lung cancer (HR = 5.807 (95 % CI, 2.946–11.447), p < 0.001) were risk factors for port infections. We also found that no local sign of infection was significantly associated with the growth of gram-negative bacilli (p = 0.031).

Conclusions

TYCO venous ports, age > 65 years, and lung cancer were all significant risk factors for IVAP-related BSIs, and no sign of infection was significantly associated with the growth of gram-negative bacilli.
Literature
1.
go back to reference Poorter RL, Lauw FN, Bemelman WA, Bakker PJ, Taat CW, Veenhof CH. Complications of an implantable venous access device (Port-a-Cath) during intermittent continuous infusion of chemotherapy. Eur J Cancer. 1996;32A:2262–6.CrossRefPubMed Poorter RL, Lauw FN, Bemelman WA, Bakker PJ, Taat CW, Veenhof CH. Complications of an implantable venous access device (Port-a-Cath) during intermittent continuous infusion of chemotherapy. Eur J Cancer. 1996;32A:2262–6.CrossRefPubMed
2.
go back to reference Biffi R, Corrado F, de Braud F, de Lucia F, Scarpa D, Testori A, et al. Long-term, totally implantable central venous access ports connected to a Groshong catheter for chemotherapy of solid tumours: experience from 178 cases using a single type of device. Eur J Cancer. 1997;33:1190–4.CrossRefPubMed Biffi R, Corrado F, de Braud F, de Lucia F, Scarpa D, Testori A, et al. Long-term, totally implantable central venous access ports connected to a Groshong catheter for chemotherapy of solid tumours: experience from 178 cases using a single type of device. Eur J Cancer. 1997;33:1190–4.CrossRefPubMed
3.
go back to reference Kock HJ, Pietsch M, Krause U, Wilke H, Eigler FW. Implantable vascular access systems: experience in 1500 patients with totally implanted central venous port systems. World J Surg. 1998;22:12–6.CrossRefPubMed Kock HJ, Pietsch M, Krause U, Wilke H, Eigler FW. Implantable vascular access systems: experience in 1500 patients with totally implanted central venous port systems. World J Surg. 1998;22:12–6.CrossRefPubMed
4.
go back to reference Zaghal A, Khalife M, Mukherji D, El MN, Shamseddine A, Hoballah J, et al. Update on totally implantable venous access devices. Surg Oncol. 2012;21:207–15.CrossRefPubMed Zaghal A, Khalife M, Mukherji D, El MN, Shamseddine A, Hoballah J, et al. Update on totally implantable venous access devices. Surg Oncol. 2012;21:207–15.CrossRefPubMed
5.
go back to reference Kim HJ, Yun J, Kim HJ, Kim KH, Kim SH, Lee SC, et al. Safety and effectiveness of central venous catheterization in patients with cancer: prospective observational study. J Korean Med Sci. 2010;25:1748–53.PubMedCentralCrossRefPubMed Kim HJ, Yun J, Kim HJ, Kim KH, Kim SH, Lee SC, et al. Safety and effectiveness of central venous catheterization in patients with cancer: prospective observational study. J Korean Med Sci. 2010;25:1748–53.PubMedCentralCrossRefPubMed
6.
go back to reference Yeste SL, Galbis Caravajal JM, Fuster Diana CA, Moledo EE. Protocol for the implantation of a venous access device (Port-A-Cath System). The complications and solutions found in 560 cases. Clin Transl Oncol. 2006;8:735–41.CrossRef Yeste SL, Galbis Caravajal JM, Fuster Diana CA, Moledo EE. Protocol for the implantation of a venous access device (Port-A-Cath System). The complications and solutions found in 560 cases. Clin Transl Oncol. 2006;8:735–41.CrossRef
7.
go back to reference Huang WT, Chen TY, Su WC, Yen CJ, Tsao CJ. Implantable venous port-related infections in cancer patients. Support Care Cancer. 2004;12:197–201.CrossRefPubMed Huang WT, Chen TY, Su WC, Yen CJ, Tsao CJ. Implantable venous port-related infections in cancer patients. Support Care Cancer. 2004;12:197–201.CrossRefPubMed
8.
go back to reference Shim J, Seo TS, Song MG, Cha IH, Kim JS, Choi CW, et al. Incidence and risk factors of infectious complications related to implantable venous-access ports. Korean J Radiol. 2014;15:494–500.PubMedCentralCrossRefPubMed Shim J, Seo TS, Song MG, Cha IH, Kim JS, Choi CW, et al. Incidence and risk factors of infectious complications related to implantable venous-access ports. Korean J Radiol. 2014;15:494–500.PubMedCentralCrossRefPubMed
9.
go back to reference Marin M, Gudiol C, Garcia-Vidal C, Ardanuy C, Carratala J. Bloodstream infections in patients with solid tumors: epidemiology, antibiotic therapy, and outcomes in 528 episodes in a single cancer center. Medicine (Baltimore). 2014;93:143–9.CrossRef Marin M, Gudiol C, Garcia-Vidal C, Ardanuy C, Carratala J. Bloodstream infections in patients with solid tumors: epidemiology, antibiotic therapy, and outcomes in 528 episodes in a single cancer center. Medicine (Baltimore). 2014;93:143–9.CrossRef
10.
go back to reference Lee GJ, Hong SH, Roh SY, Park SR, Lee MA, Chun HG, et al. A case–control study to identify risk factors for totally implantable central venous port-related bloodstream infection. Cancer Res Treat. 2014;46:250–60.PubMedCentralCrossRefPubMed Lee GJ, Hong SH, Roh SY, Park SR, Lee MA, Chun HG, et al. A case–control study to identify risk factors for totally implantable central venous port-related bloodstream infection. Cancer Res Treat. 2014;46:250–60.PubMedCentralCrossRefPubMed
11.
go back to reference Anatoliotaki M, Valatas V, Mantadakis E, Apostolakou H, Mavroudis D, Georgoulias V, et al. Bloodstream infections in patients with solid tumors: associated factors, microbial spectrum and outcome. Infection. 2004;32:65–71.CrossRefPubMed Anatoliotaki M, Valatas V, Mantadakis E, Apostolakou H, Mavroudis D, Georgoulias V, et al. Bloodstream infections in patients with solid tumors: associated factors, microbial spectrum and outcome. Infection. 2004;32:65–71.CrossRefPubMed
12.
go back to reference Samaras P, Dold S, Braun J, Kestenholz P, Breitenstein S, Imhof A, et al. Infectious port complications are more frequent in younger patients with hematologic malignancies than in solid tumor patients. Oncology. 2008;74:237–44.CrossRefPubMed Samaras P, Dold S, Braun J, Kestenholz P, Breitenstein S, Imhof A, et al. Infectious port complications are more frequent in younger patients with hematologic malignancies than in solid tumor patients. Oncology. 2008;74:237–44.CrossRefPubMed
13.
go back to reference Liaw CC, Chen JS, Chang HK, Huang JS, Yang TS, Liau CT. Symptoms and signs of port-related infections in oncology patients related to the offending pathogens. Int J Clin Pract. 2008;62:1193–8.CrossRefPubMed Liaw CC, Chen JS, Chang HK, Huang JS, Yang TS, Liau CT. Symptoms and signs of port-related infections in oncology patients related to the offending pathogens. Int J Clin Pract. 2008;62:1193–8.CrossRefPubMed
14.
go back to reference Caers J, Fontaine C, Vinh-Hung V, De MJ, Ponnet G, Oost C, et al. Catheter tip position as a risk factor for thrombosis associated with the use of subcutaneous infusion ports. Support Care Cancer. 2005;13:325–31.CrossRefPubMed Caers J, Fontaine C, Vinh-Hung V, De MJ, Ponnet G, Oost C, et al. Catheter tip position as a risk factor for thrombosis associated with the use of subcutaneous infusion ports. Support Care Cancer. 2005;13:325–31.CrossRefPubMed
15.
go back to reference Fan WC, Wu CH, Tsai MJ, Tsai YM, Chang HL, Hung JY, et al. Risk factors for venous port migration in a single institute in Taiwan. World J Surg Oncol. 2014;12:15.PubMedCentralCrossRefPubMed Fan WC, Wu CH, Tsai MJ, Tsai YM, Chang HL, Hung JY, et al. Risk factors for venous port migration in a single institute in Taiwan. World J Surg Oncol. 2014;12:15.PubMedCentralCrossRefPubMed
16.
go back to reference Pascual A. Pathogenesis of catheter-related infections: lessons for new designs. Clin Microbiol Infect. 2002;8:256–64.CrossRefPubMed Pascual A. Pathogenesis of catheter-related infections: lessons for new designs. Clin Microbiol Infect. 2002;8:256–64.CrossRefPubMed
17.
go back to reference Darouiche RO. Device-associated infections: a macroproblem that starts with microadherence. Clin Infect Dis. 2001;33:1567–72.CrossRefPubMed Darouiche RO. Device-associated infections: a macroproblem that starts with microadherence. Clin Infect Dis. 2001;33:1567–72.CrossRefPubMed
18.
go back to reference Mehall JR, Saltzman DA, Jackson RJ, Smith SD. Catheter materials affect the incidence of late blood-borne catheter infection. Surg Infect (Larchmt ). 2001;2:225–9.CrossRef Mehall JR, Saltzman DA, Jackson RJ, Smith SD. Catheter materials affect the incidence of late blood-borne catheter infection. Surg Infect (Larchmt ). 2001;2:225–9.CrossRef
19.
go back to reference Galliani S, Cremieux A, van der Auwera P, Viot M. Influence of strain, biomaterial, proteins, and oncostatic chemotherapy on Staphylococcus epidermidis adhesion to intravascular catheters in vitro. J Lab Clin Med. 1996;127:71–80.CrossRefPubMed Galliani S, Cremieux A, van der Auwera P, Viot M. Influence of strain, biomaterial, proteins, and oncostatic chemotherapy on Staphylococcus epidermidis adhesion to intravascular catheters in vitro. J Lab Clin Med. 1996;127:71–80.CrossRefPubMed
20.
go back to reference Kristinsson KG. Adherence of staphylococci to intravascular catheters. J Med Microbiol. 1989;28:249–57.CrossRefPubMed Kristinsson KG. Adherence of staphylococci to intravascular catheters. J Med Microbiol. 1989;28:249–57.CrossRefPubMed
21.
go back to reference Fischer L, Knebel P, Schroder S, Bruckner T, Diener MK, Hennes R, et al. Reasons for explantation of totally implantable access ports: a multivariate analysis of 385 consecutive patients. Ann Surg Oncol. 2008;15:1124–9.CrossRefPubMed Fischer L, Knebel P, Schroder S, Bruckner T, Diener MK, Hennes R, et al. Reasons for explantation of totally implantable access ports: a multivariate analysis of 385 consecutive patients. Ann Surg Oncol. 2008;15:1124–9.CrossRefPubMed
22.
go back to reference Ahn SJ, Kim HC, Chung JW, An SB, Yin YH, Jae HJ, et al. Ultrasound and fluoroscopy-guided placement of central venous ports via internal jugular vein: retrospective analysis of 1254 port implantations at a single center. Korean J Radiol. 2012;13:314–23.PubMedCentralCrossRefPubMed Ahn SJ, Kim HC, Chung JW, An SB, Yin YH, Jae HJ, et al. Ultrasound and fluoroscopy-guided placement of central venous ports via internal jugular vein: retrospective analysis of 1254 port implantations at a single center. Korean J Radiol. 2012;13:314–23.PubMedCentralCrossRefPubMed
23.
go back to reference Gapany C, Tercier S, Diezi M, Clement C, Lemay K, Joseph JM. Frequent accesses to totally implanted vascular ports in pediatric oncology patients are associated with higher infection rates. J Vasc Access. 2011;12:207–10.CrossRefPubMed Gapany C, Tercier S, Diezi M, Clement C, Lemay K, Joseph JM. Frequent accesses to totally implanted vascular ports in pediatric oncology patients are associated with higher infection rates. J Vasc Access. 2011;12:207–10.CrossRefPubMed
24.
go back to reference Laurenzi L, Natoli S, Benedetti C, Marcelli ME, Tirelli W, DiEmidio L, et al. Cutaneous bacterial colonization, modalities of chemotherapeutic infusion, and catheter-related bloodstream infection in totally implanted venous access devices. Support Care Cancer. 2004;12:805–9.CrossRefPubMed Laurenzi L, Natoli S, Benedetti C, Marcelli ME, Tirelli W, DiEmidio L, et al. Cutaneous bacterial colonization, modalities of chemotherapeutic infusion, and catheter-related bloodstream infection in totally implanted venous access devices. Support Care Cancer. 2004;12:805–9.CrossRefPubMed
25.
go back to reference Heibl C, Trommet V, Burgstaller S, Mayrbaeurl B, Baldinger C, Koplmuller R, et al. Complications associated with the use of Port-a-Caths in patients with malignant or haematological disease: a single-centre prospective analysis. Eur J Cancer Care (Engl ). 2010;19:676–81.CrossRef Heibl C, Trommet V, Burgstaller S, Mayrbaeurl B, Baldinger C, Koplmuller R, et al. Complications associated with the use of Port-a-Caths in patients with malignant or haematological disease: a single-centre prospective analysis. Eur J Cancer Care (Engl ). 2010;19:676–81.CrossRef
26.
go back to reference Penzak SR, Gubbins PO, Stratton SL, Anaissie EJ. Investigation of an outbreak of gram-negative bacteremia among hematology-oncology outpatients. Infect Control Hosp Epidemiol. 2000;21:597–9.CrossRefPubMed Penzak SR, Gubbins PO, Stratton SL, Anaissie EJ. Investigation of an outbreak of gram-negative bacteremia among hematology-oncology outpatients. Infect Control Hosp Epidemiol. 2000;21:597–9.CrossRefPubMed
27.
go back to reference Groeger JS, Lucas AB, Thaler HT, Friedlander-Klar H, Brown AE, Kiehn TE, et al. Infectious morbidity associated with long-term use of venous access devices in patients with cancer. Ann Intern Med. 1993;119:1168–74.CrossRefPubMed Groeger JS, Lucas AB, Thaler HT, Friedlander-Klar H, Brown AE, Kiehn TE, et al. Infectious morbidity associated with long-term use of venous access devices in patients with cancer. Ann Intern Med. 1993;119:1168–74.CrossRefPubMed
28.
go back to reference Castagnola E, Garaventa A, Viscoli C, Carrega G, Nantron M, Molinari C, et al. Changing pattern of pathogens causing broviac catheter-related bacteraemias in children with cancer. J Hosp Infect. 1995;29:129–33.CrossRefPubMed Castagnola E, Garaventa A, Viscoli C, Carrega G, Nantron M, Molinari C, et al. Changing pattern of pathogens causing broviac catheter-related bacteraemias in children with cancer. J Hosp Infect. 1995;29:129–33.CrossRefPubMed
29.
go back to reference Barbut F, Soukouna S, Lalande V, Garcia ML, Neyme D, de Gramont A, et al. [Totally implantable venous access ports: frequency of complications and analysis of bacterial contamination after ablation]. Pathol Biol (Paris). 2004;52:566–74.CrossRef Barbut F, Soukouna S, Lalande V, Garcia ML, Neyme D, de Gramont A, et al. [Totally implantable venous access ports: frequency of complications and analysis of bacterial contamination after ablation]. Pathol Biol (Paris). 2004;52:566–74.CrossRef
30.
go back to reference Douard MC, Arlet G, Longuet P, Troje C, Rouveau M, Ponscarme D, et al. Diagnosis of venous access port-related infections. Clin Infect Dis. 1999;29:1197–202.CrossRefPubMed Douard MC, Arlet G, Longuet P, Troje C, Rouveau M, Ponscarme D, et al. Diagnosis of venous access port-related infections. Clin Infect Dis. 1999;29:1197–202.CrossRefPubMed
Metadata
Title
Port type is a possible risk factor for implantable venous access port-related bloodstream infections and no sign of local infection predicts the growth of gram-negative bacilli
Authors
Jui-Feng Hsu
Hsu-Liang Chang
Ming-Ju Tsai
Ying-Ming Tsai
Yen-Lung Lee
Pei-Huan Chen
Wen-Chieh Fan
Yu-Chung Su
Chih-Jen Yang
Publication date
01-12-2015
Publisher
BioMed Central
Published in
World Journal of Surgical Oncology / Issue 1/2015
Electronic ISSN: 1477-7819
DOI
https://doi.org/10.1186/s12957-015-0707-2

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