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Published in: International Journal for Equity in Health 1/2020

Open Access 01-12-2020 | Care | Research

Sex differences in the management of persons with dementia following a subnational primary care policy intervention

Published in: International Journal for Equity in Health | Issue 1/2020

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Abstract

Background

The influence of sex and gender on the risk of dementia, its clinical presentation and progression is increasingly being recognized. However, current dementia strategies have not explicitly considered sex and gender differences in the management of dementia to ensure equitable care. The objective of this study was to examine the moderating effect of sex on the quality of care following the implementation of the Quebec Alzheimer Plan (QAP).

Methods

We conducted a secondary analysis of the evaluation of the QAP consisting of a retrospective chart review of 945 independent, randomly-selected patient charts of males and females 75+ years old with dementia and a visit to one of 13 participating Family Medicine Groups before (October 2011–July 2013) and after (October 2014 – July 2015). The quality of dementia care score, based on Canadian and international recommendations and consensus guidelines, consisted of documented assessments in 10 domains. We used a mixed linear regression model to measure the interaction between sex and the implementation of the QAP on the quality of dementia care score, adjusting for age and number of medications.

Results

We found that improvements in the quality of dementia care following the QAP were larger for men than women (mean difference = 4.97; 95%CI: 0.08, 9.85). We found that men had a larger improvement in four indicators (driving assessments, dementia medication management, Alzheimer Society referrals, and functional status evaluation), while women had a smaller improvement in three (home care needs, behavioural and psychological symptoms of dementia, and weight). Men were prescribed fewer anticholinergics post-QAP, while women were prescribed more. Cognitive testing improved in men but decreased for women following the QAP; the opposite was observed for caregiver needs.

Conclusion

While the overall quality of care improved after the implementation of the QAP, this study reveals differences in dementia management between men and women. While we identified areas of inequalities in the care received, it is unclear whether this represents inequities in access to care and health outcomes. Future research should focus on better understanding sex and gender-specific needs in dementia to bridge this gap and better inform dementia strategies.
Literature
1.
go back to reference Gates Foundation. Goalkeepers report: examining inequality. 2019. Gates Foundation. Goalkeepers report: examining inequality. 2019.
2.
go back to reference United Nations. The World’s women 2010: trends and statistics. New York, Affairs DoEaS; 2010. United Nations. The World’s women 2010: trends and statistics. New York, Affairs DoEaS; 2010.
3.
go back to reference World Bank. World Development Report 2012: Gender Equality and Development 2012.CrossRef World Bank. World Development Report 2012: Gender Equality and Development 2012.CrossRef
4.
go back to reference Vlassoff C. Gender differences in determinants and consequences of health and illness. J Health Popul Nutr. 2007;25(1):47–61.PubMedPubMedCentral Vlassoff C. Gender differences in determinants and consequences of health and illness. J Health Popul Nutr. 2007;25(1):47–61.PubMedPubMedCentral
5.
go back to reference World Health Organization. Women and Health: Today’s Evidence Tomorrows Agenda. Geneva: WHO Press; 2009. World Health Organization. Women and Health: Today’s Evidence Tomorrows Agenda. Geneva: WHO Press; 2009.
6.
go back to reference Katz SJ, Kabeto M, Langa KM. Gender disparities in the receipt of home care for elderly people with disability in the United States. Jama. 2000;284(23):3022–7.CrossRef Katz SJ, Kabeto M, Langa KM. Gender disparities in the receipt of home care for elderly people with disability in the United States. Jama. 2000;284(23):3022–7.CrossRef
7.
go back to reference Green CA, Pope CR. Gender, psychosocial factors and the use of medical services: a longitudinal analysis. Soc Sci Med. 1999;48(10):1363–72.CrossRef Green CA, Pope CR. Gender, psychosocial factors and the use of medical services: a longitudinal analysis. Soc Sci Med. 1999;48(10):1363–72.CrossRef
8.
go back to reference Vaidya V, Partha G, Karmakar M. Gender differences in utilization of preventive care services in the United States. J Women’s Health (2002). 2012;21(2):140–5.CrossRef Vaidya V, Partha G, Karmakar M. Gender differences in utilization of preventive care services in the United States. J Women’s Health (2002). 2012;21(2):140–5.CrossRef
9.
go back to reference Thompson AE, Anisimowicz Y, Miedema B, Hogg W, Wodchis WP, Aubrey-Bassler K. The influence of gender and other patient characteristics on health care-seeking behaviour: a QUALICOPC study. BMC Fam Pract. 2016;17(1):38.CrossRef Thompson AE, Anisimowicz Y, Miedema B, Hogg W, Wodchis WP, Aubrey-Bassler K. The influence of gender and other patient characteristics on health care-seeking behaviour: a QUALICOPC study. BMC Fam Pract. 2016;17(1):38.CrossRef
11.
go back to reference Institute of Medicine Committee on Women's Health R. Women's Health Research: Progress, Pitfalls, and Promise. Washington (DC): National Academies Press (US), Copyright 2010 by the National Academy of Sciences. All rights reserved; 2010. Institute of Medicine Committee on Women's Health R. Women's Health Research: Progress, Pitfalls, and Promise. Washington (DC): National Academies Press (US), Copyright 2010 by the National Academy of Sciences. All rights reserved; 2010.
12.
go back to reference Regitz-Zagrosek V. Sex and gender differences in health. Science & Society Series on sex and science. EMBO Rep. 2012;13(7):596–603.CrossRef Regitz-Zagrosek V. Sex and gender differences in health. Science & Society Series on sex and science. EMBO Rep. 2012;13(7):596–603.CrossRef
13.
go back to reference Nebel RA, Aggarwal NT, Barnes LL, Gallagher A, Goldstein JM, Kantarci K, et al. Understanding the impact of sex and gender in Alzheimer's disease: a call to action. Alzheimers Dement. 2018;14(9):1171–83.CrossRef Nebel RA, Aggarwal NT, Barnes LL, Gallagher A, Goldstein JM, Kantarci K, et al. Understanding the impact of sex and gender in Alzheimer's disease: a call to action. Alzheimers Dement. 2018;14(9):1171–83.CrossRef
15.
go back to reference Prince M, Ali GC, Guerchet M, Prina AM, Albanese E, Wu YT. Recent global trends in the prevalence and incidence of dementia, and survival with dementia. Alzheimers Res Ther. 2016;8(1):23.CrossRef Prince M, Ali GC, Guerchet M, Prina AM, Albanese E, Wu YT. Recent global trends in the prevalence and incidence of dementia, and survival with dementia. Alzheimers Res Ther. 2016;8(1):23.CrossRef
16.
go back to reference Livingston G, Sommerlad A, Orgeta V, Costafreda SG, Huntley J, Ames D, et al. Dementia prevention, intervention, and care. Lancet. 2017;390(10113):2673–734.CrossRef Livingston G, Sommerlad A, Orgeta V, Costafreda SG, Huntley J, Ames D, et al. Dementia prevention, intervention, and care. Lancet. 2017;390(10113):2673–734.CrossRef
17.
go back to reference Kessler RC, McGonagle KA, Swartz M, Blazer DG, Nelson CB. Sex and depression in the National Comorbidity Survey. I: lifetime prevalence, chronicity and recurrence. J Affect Disord. 1993;29(2–3):85–96.CrossRef Kessler RC, McGonagle KA, Swartz M, Blazer DG, Nelson CB. Sex and depression in the National Comorbidity Survey. I: lifetime prevalence, chronicity and recurrence. J Affect Disord. 1993;29(2–3):85–96.CrossRef
18.
go back to reference Kramer JH, Yaffe K, Lengenfelder J, Delis DC. Age and gender interactions on verbal memory performance. J Int Neuropsychol Soc. 2003;9(1):97–102.CrossRef Kramer JH, Yaffe K, Lengenfelder J, Delis DC. Age and gender interactions on verbal memory performance. J Int Neuropsychol Soc. 2003;9(1):97–102.CrossRef
19.
go back to reference Tschanz JT, Corcoran CD, Schwartz S, Treiber K, Green RC, Norton MC, et al. Progression of cognitive, functional, and neuropsychiatric symptom domains in a population cohort with Alzheimer dementia: the Cache County dementia progression study. Am J Geriatr Psychiatry. 2011;19(6):532–42.CrossRef Tschanz JT, Corcoran CD, Schwartz S, Treiber K, Green RC, Norton MC, et al. Progression of cognitive, functional, and neuropsychiatric symptom domains in a population cohort with Alzheimer dementia: the Cache County dementia progression study. Am J Geriatr Psychiatry. 2011;19(6):532–42.CrossRef
20.
go back to reference Irvine K, Laws KR, Gale TM, Kondel TK. Greater cognitive deterioration in women than men with Alzheimer's disease: a meta analysis. J Clin Exp Neuropsychol. 2012;34(9):989–98.CrossRef Irvine K, Laws KR, Gale TM, Kondel TK. Greater cognitive deterioration in women than men with Alzheimer's disease: a meta analysis. J Clin Exp Neuropsychol. 2012;34(9):989–98.CrossRef
21.
go back to reference Gambassi G, Lapane KL, Landi F, Sgadari A, Mor V, Bernabie R. Gender differences in the relation between comorbidity and mortality of patients with Alzheimer's disease. Systematic assessment of geriatric drug use via epidemiology (SAGE) study group. Neurology. 1999;53(3):508–16.CrossRef Gambassi G, Lapane KL, Landi F, Sgadari A, Mor V, Bernabie R. Gender differences in the relation between comorbidity and mortality of patients with Alzheimer's disease. Systematic assessment of geriatric drug use via epidemiology (SAGE) study group. Neurology. 1999;53(3):508–16.CrossRef
22.
go back to reference Nelis SM, Wu YT, Matthews FE, Martyr A, Quinn C, Rippon I, et al. The impact of co-morbidity on the quality of life of people with dementia: findings from the IDEAL study. Age Ageing. 2019;48(3):361–7.CrossRef Nelis SM, Wu YT, Matthews FE, Martyr A, Quinn C, Rippon I, et al. The impact of co-morbidity on the quality of life of people with dementia: findings from the IDEAL study. Age Ageing. 2019;48(3):361–7.CrossRef
23.
go back to reference Rosenwax L, McNamara B, Zilkens R. A population-based retrospective cohort study comparing care for Western Australians with and without Alzheimer's disease in the last year of life. Health Soc Care Commun. 2009;17(1):36–44.CrossRef Rosenwax L, McNamara B, Zilkens R. A population-based retrospective cohort study comparing care for Western Australians with and without Alzheimer's disease in the last year of life. Health Soc Care Commun. 2009;17(1):36–44.CrossRef
24.
go back to reference Bronskill S, Camacho X, Corbett L, Gill S, Gruneir A, Ho M, et al. Health system use by frail Ontario seniors: an in-depth examination of four vulnerable cohorts: Institute for Clinical Evaluative Sciences; 2011. Bronskill S, Camacho X, Corbett L, Gill S, Gruneir A, Ho M, et al. Health system use by frail Ontario seniors: an in-depth examination of four vulnerable cohorts: Institute for Clinical Evaluative Sciences; 2011.
25.
go back to reference Lyketsos CG, Steele C, Galik E, Rosenblatt A, Steinberg M, Warren A, et al. Physical aggression in dementia patients and its relationship to depression. Am J Psychiatry. 1999;156(1):66–71.CrossRef Lyketsos CG, Steele C, Galik E, Rosenblatt A, Steinberg M, Warren A, et al. Physical aggression in dementia patients and its relationship to depression. Am J Psychiatry. 1999;156(1):66–71.CrossRef
26.
go back to reference Zuidema SU, de Jonghe JF, Verhey FR, Koopmans RT. Predictors of neuropsychiatric symptoms in nursing home patients: influence of gender and dementia severity. Int J Geriatr Psychiatr. 2009;24(10):1079–86.CrossRef Zuidema SU, de Jonghe JF, Verhey FR, Koopmans RT. Predictors of neuropsychiatric symptoms in nursing home patients: influence of gender and dementia severity. Int J Geriatr Psychiatr. 2009;24(10):1079–86.CrossRef
27.
go back to reference Bartlett R, Gjernes T, Lotherington AT, Obstefelder A. Gender, citizenship and dementia care: a scoping review of studies to inform policy and future research. In: Health & social care in the community; 2016. Bartlett R, Gjernes T, Lotherington AT, Obstefelder A. Gender, citizenship and dementia care: a scoping review of studies to inform policy and future research. In: Health & social care in the community; 2016.
29.
go back to reference Ministère de la Santé et des Services Sociaux du Québec. Relever le défi de la maladie d’Alzheimer et des maladies apparentées : une vision centrée sur la personne, l’humanisme et l’excellence. Rapport du comité d’experts en vue de l’élaboration d’un plan d’action pour la maladie d’Alzheimer. Rapport présidé par le Professeur Howard Bergman 2009 [Available from: http://publications.msss.gouv.qc.ca/msss/document-000869/. Ministère de la Santé et des Services Sociaux du Québec. Relever le défi de la maladie d’Alzheimer et des maladies apparentées : une vision centrée sur la personne, l’humanisme et l’excellence. Rapport du comité d’experts en vue de l’élaboration d’un plan d’action pour la maladie d’Alzheimer. Rapport présidé par le Professeur Howard Bergman 2009 [Available from: http://​publications.​msss.​gouv.​qc.​ca/​msss/​document-000869/​.
30.
go back to reference Vedel I, Sourial N, Arsenault-Lapierre G, Godard-Sebillotte C, Bergman H. Impact of the Quebec Alzheimer plan on the detection and management of Alzheimer disease and other neurocognitive disorders in primary health care: a retrospective study. CMAJ Open. 2019;7(2):E391–E8.CrossRef Vedel I, Sourial N, Arsenault-Lapierre G, Godard-Sebillotte C, Bergman H. Impact of the Quebec Alzheimer plan on the detection and management of Alzheimer disease and other neurocognitive disorders in primary health care: a retrospective study. CMAJ Open. 2019;7(2):E391–E8.CrossRef
31.
go back to reference Arsenault-Lapierre G, Godard-Sebillotte C, Sourial N, Couturier Y, Bouchard P, Pilon C, et al. Le Plan Alzheimer Québécois, un plan basé sur les soins primaires / The Quebec Alzheimer Plan, a Plan Based in Primary Care. La revue de Santé Publique. 2020;Accepted. Arsenault-Lapierre G, Godard-Sebillotte C, Sourial N, Couturier Y, Bouchard P, Pilon C, et al. Le Plan Alzheimer Québécois, un plan basé sur les soins primaires / The Quebec Alzheimer Plan, a Plan Based in Primary Care. La revue de Santé Publique. 2020;Accepted.
32.
go back to reference Statistic Canada. Quebec [Province] and Canada [Country] (table). Census Profile. 2016 Census. . Ottawa; 2017 Released November 29, 2017. Contract No.: Statistics Canada Catalogue no. 98–316-X2016001. . Statistic Canada. Quebec [Province] and Canada [Country] (table). Census Profile. 2016 Census. . Ottawa; 2017 Released November 29, 2017. Contract No.: Statistics Canada Catalogue no. 98–316-X2016001. .
34.
go back to reference Wenger NS, Roth CP, Shekelle P. ACOVE investigators. Introduction to the assessing care of vulnerable elders-3 quality indicator measurement set. J Am Geriatr Soc. 2007;55(S2):S247–S52.CrossRef Wenger NS, Roth CP, Shekelle P. ACOVE investigators. Introduction to the assessing care of vulnerable elders-3 quality indicator measurement set. J Am Geriatr Soc. 2007;55(S2):S247–S52.CrossRef
35.
go back to reference Callahan CM, Sachs GA, LaMantia MA, Unroe KT, Arling G, Boustani MA. Redesigning systems of care for older adults with Alzheimer’s disease. Health Aff. 2014;33(4):626–32.CrossRef Callahan CM, Sachs GA, LaMantia MA, Unroe KT, Arling G, Boustani MA. Redesigning systems of care for older adults with Alzheimer’s disease. Health Aff. 2014;33(4):626–32.CrossRef
36.
go back to reference Bierman AS, Pugh MJV, Dhalla I, Amuan M, Graeme Fincke B, Rosen A, et al. Sex differences in inappropriate prescribing among elderly veterans. Am J Geriatr Pharmacother. 2007;5(2):147–61.CrossRef Bierman AS, Pugh MJV, Dhalla I, Amuan M, Graeme Fincke B, Rosen A, et al. Sex differences in inappropriate prescribing among elderly veterans. Am J Geriatr Pharmacother. 2007;5(2):147–61.CrossRef
37.
go back to reference Valladales-Restrepo LF, Duran-Lengua M, Machado-Alba JE. Potentially inappropriate prescriptions of anticholinergics drugs in Alzheimer's disease patients. Geriatr Gerontol Int. 2019;19(9):913–7.CrossRef Valladales-Restrepo LF, Duran-Lengua M, Machado-Alba JE. Potentially inappropriate prescriptions of anticholinergics drugs in Alzheimer's disease patients. Geriatr Gerontol Int. 2019;19(9):913–7.CrossRef
38.
go back to reference Trenaman SC, Rideout M, Andrew MK. Sex and gender differences in polypharmacy in persons with dementia: a scoping review. SAGE Open Med. 2019;7:2050312119845715.CrossRef Trenaman SC, Rideout M, Andrew MK. Sex and gender differences in polypharmacy in persons with dementia: a scoping review. SAGE Open Med. 2019;7:2050312119845715.CrossRef
39.
go back to reference Rochon PA, Gruneir A, Gill SS, Wu W, Zhu L, Herrmann N, et al. Initial cholinesterase inhibitor therapy dose and serious events in older women and men. J Am Geriatr Soc. 2018;66(9):1692–9.CrossRef Rochon PA, Gruneir A, Gill SS, Wu W, Zhu L, Herrmann N, et al. Initial cholinesterase inhibitor therapy dose and serious events in older women and men. J Am Geriatr Soc. 2018;66(9):1692–9.CrossRef
40.
go back to reference Bogardus ST Jr, Towle V, Williams CS, Desai MM, Inouye SK. What does the medical record reveal about functional status? A comparison of medical record and interview data. J Gen Intern Med. 2001;16(11):728–36.CrossRef Bogardus ST Jr, Towle V, Williams CS, Desai MM, Inouye SK. What does the medical record reveal about functional status? A comparison of medical record and interview data. J Gen Intern Med. 2001;16(11):728–36.CrossRef
41.
go back to reference Foley DJ, Heimovitz HK, Guralnik JM, Brock DB. Driving life expectancy of persons aged 70 years and older in the United States. Am J Public Health. 2002;92(8):1284–9.CrossRef Foley DJ, Heimovitz HK, Guralnik JM, Brock DB. Driving life expectancy of persons aged 70 years and older in the United States. Am J Public Health. 2002;92(8):1284–9.CrossRef
42.
go back to reference Baines N, Au B, Rapoport MJ, Naglie G, Tierney MC. Meta-analysis of driving cessation and dementia: does sex matter? J Gerontol. 2016;73(7):1185–9. Baines N, Au B, Rapoport MJ, Naglie G, Tierney MC. Meta-analysis of driving cessation and dementia: does sex matter? J Gerontol. 2016;73(7):1185–9.
43.
go back to reference Forbes DA, Jansen SL, Markle-Reid M, Hawranik P, Morgan D, Henderson S, et al. Gender differences in use and availability of home and community-based services for people with dementia. Can J Nurs Res. 2008;40(1):39–59.PubMed Forbes DA, Jansen SL, Markle-Reid M, Hawranik P, Morgan D, Henderson S, et al. Gender differences in use and availability of home and community-based services for people with dementia. Can J Nurs Res. 2008;40(1):39–59.PubMed
Metadata
Title
Sex differences in the management of persons with dementia following a subnational primary care policy intervention
Publication date
01-12-2020
Published in
International Journal for Equity in Health / Issue 1/2020
Electronic ISSN: 1475-9276
DOI
https://doi.org/10.1186/s12939-020-01285-2

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