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Open Access 01-12-2017 | Case report

The drug transporter ABCB1 c.3435C>T SNP influences artemether–lumefantrine treatment outcome

Published in: Malaria Journal | Issue 1/2017

Abstract

Malaria treatment performance is potentially influenced by pharmacogenetic factors. This study reports an association study between the ABCB1 c.3435C>T, CYP3A4*1B (g.-392A>G), CYP3A5*3 (g.6986A>G) SNPs and artemether + lumefantrine treatment outcome in 103 uncomplicated malaria patients from Angola. No significant associations with the CYP3A4*1B and CYP3A5*3 were observed, while a significant predominance of the ABCB1 c.3435CC genotype was found among the recurrent infection-free patients (p < 0.01), suggesting a role for this transporter in AL inter-individual performance.

World Health Organization. World malaria report 2015. Geneva: World Health Organization; 2015.

Dandara C, Swart M, Mpeta B, Wonkam A, Masimirembwa C. Cytochrome P450 pharmacogenetics in African populations: implications for public health. Expert Opin Drug Metab Toxicol. 2014;10:769–85.CrossRefPubMed

Piedade R, Gil JP. The pharmacogenetics of antimalaria artemisinin combination therapy. Expert Opin Drug Metab Toxicol. 2011;7:1185–200.CrossRefPubMed

World Health Organization. Guidelines for the treatment of malaria. 3rd ed. Geneva: World Health Organization; 2005.

Djimdé A, Lefèvre G. Understanding the pharmacokinetics of Coartem. Malar J. 2009;8(Suppl 1):S4.CrossRefPubMedPubMedCentral

Lefèvre G, Carpenter P, Souppart C, Schmidli H, McClean M, Stypinski D. Pharmacokinetics and electrocardiographic pharmacodynamics of artemether-lumefantrine (Riamet) with concomitant administration of ketoconazole in healthy subjects. Br J Clin Pharmacol. 2002;54:485–92.CrossRefPubMedPubMedCentral

Raju KS, Singh SP, Taneja I. Investigation of the functional role of P-glycoprotein in limiting the oral bioavailability of lumefantrine. Antimicrob Agents Chemother. 2014;58:489–94.CrossRefPubMedPubMedCentral

Oga EF, Sekine S, Shitara Y, Horie T. Potential P-glycoprotein-mediated drug-drug interactions of antimalarial agents in Caco-2 cells. Am J Trop Med Hyg. 2012;87:64–9.CrossRefPubMedPubMedCentral

Staehli-Hodel EM, Csajka C, Ariey F, Guidi M, Kabanywanyi AM, Duong S, et al. Effect of single nucleotide polymorphisms in cytochrome P450 isoenzyme and N-acetyltransferase 2 genes on the metabolism of artemisinin-based combination therapies in malaria patients from Cambodia and Tanzania. Antimicrob Agents Chemother. 2013;57:950–8.CrossRefPubMedPubMedCentral

10.

Kiaco K, Teixeira J, Machado M, do Rosário V, Lopes D. Evaluation of artemether-lumefantrine efficacy in the treatment of uncomplicated malaria and its association with pfmdr1, pfatpase6 and K13-propeller polymorphisms in Luanda, Angola. Malar J. 2015;14:504.CrossRefPubMedPubMedCentral

11.

WHO. World malaria report 2016. Geneva: World Health Organization; 2016.

12.

Fançony C, Brito M, Gil JP. Plasmodium falciparum drug resistance in Angola. Malar J. 2016;15:74.CrossRefPubMedPubMedCentral

13.

Cavaco I, Gil JP, Gil-Berglund E, Ribeiro V. CYP3A4 and MDR1 alleles in a Portuguese population. Clin Chem Lab Med. 2003;41:1345–50.PubMed

14.

Malmberg M, Ferreira PE, Tarning J, Ursing J, Ngasala B, Björkman A, et al. Plasmodium falciparum drug resistance phenotype as assessed by patient antimalarial drug levels and its association with pfmdr1 polymorphisms. J Infect Dis. 2013;207:842–7.CrossRefPubMed

15.

Venkatesan M, Gadalla NB, Stepniewska K, Dahal P, Nsanzabana C, Moriera C, et al. Polymorphisms in Plasmodium falciparum chloroquine resistance transporter and multidrug resistance 1 genes: parasite risk factors that affect treatment outcomes for P. falciparum malaria after artemether-lumefantrine and artesunate-amodiaquine. Am J Trop Med Hyg. 2014;91:833–43.CrossRefPubMedPubMedCentral

16.

Mutagonda RF, Kamuhabwa AAR, Minzi OMS, Massawe SN, Asghar M, Homann MV, et al. Effect of pharmacogenetics on plasma lumefantrine pharmacokinetics and malaria treatment outcome in pregnant women. Malar J. 2017;16:267.CrossRefPubMedPubMedCentral

17.

Kuehl P, Zhang J, Lin Y, Lamba J, Assem M, Schuetz J, et al. Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression. Nat Genet. 2001;27:383–91.CrossRefPubMed

18.

Cousin M, Kummerer S, Leefvre G, Marrast AC, Stein D, Weaver M. Coartem (artemether-lumefantrine) tablets for the treatment of malaria in patients with acute, uncomplicated infections due to Plasmodium falciparum or mixed infections including P. falciparum. Advisory Committee Briefing Book, Novartis, October 2008.

19.

Wong RP, Salman S, Ilett KF, Siba PM, Mueller I, Davis TM. Desbutyl-lumefantrine is a metabolite of lumefantrine with potent in vitro antimalarial activity that may influence artemether-lumefantrine treatment outcome. Antimicrob Agents Chemother. 2011;55:1194–8.CrossRefPubMedPubMedCentral

20.

Maganda BA, Minzi OM, Ngaimisi E, Kamuhabwa AA, Aklillu E. CYP2B6*6 genotype and high efavirenz plasma concentration but not nevirapine are associated with low lumefantrine plasma exposure and poor treatment response in HIV-malaria-coinfected patients. Pharmacogenom J. 2016;16:88–95.CrossRef

21.

Kimchi-Sarfaty C, Oh JM, Kim IW, Sauna ZE, Calcagno AM, Ambudkar SV, et al. A “silent” polymorphism in the MDR1 gene changes substrate specificity. Science. 2007;315:525–8.CrossRefPubMed

22.

Cheung CY, Op den Buijsch RA, Wong KM, Chan HW, Chau KF, Li CS, et al. Influence of different allelic variants of the CYP3A and ABCBI genes on the tacrolimus pharmacokinetic profile of Chinese renal transplant recipients. Pharmacogenomics. 2006;7:563–74.CrossRefPubMed

23.

Kravljaca M, Perovic V, Pravica V, Brkovic V, Milinkovic M, Lausevic M, et al. The importance of MDR1 gene polymorphisms for tacrolimus dosage. Eur J Pharm Sci. 2016;83:109–13.CrossRefPubMed

24.

Tan ZR, Zhou YX, Liu J, Huang WH, Chen Y, Wang YC, et al. The influence of ABCB1 polymorphism C3435T on the pharmacokinetics of silibinin. J Clin Pharm Ther. 2015;40:685–8.CrossRefPubMed

25.

Kim KA, Park PW, Park JY. Effect of ABCB1 (MDR1) haplotypes derived from G2677T/C3435T on the pharmacokinetics of amlodipine in healthy subjects. Br J Clin Pharmacol. 2007;63:53–8.CrossRefPubMed

26.

Sakaeda T, Nakamura T, Horinouchi M, Kakumoto M, Ohmoto N, Sakai T, et al. MDR1 genotype-related pharmacokinetics of digoxin after single oral administration in healthy Japanese subjects. Pharm Res. 2001;18:1400–4.CrossRefPubMed

27.

Vos K, Sciuto CL, Piedade R, Ashton M, Björkman A, Ngasala B, Mårtensson A, Gil JP. MRP2/ABCC2 C1515Y polymorphism modulates exposure to lumefantrine during artemether-lumefantrine antimalarial therapy. Pharmacogenomics. 2017;18:981–5.CrossRefPubMed

Title: The drug transporter ABCB1 c.3435C>T SNP influences artemether–lumefantrine treatment outcome
Publication date: 01-12-2017
Published in: Malaria Journal / Issue 1/2017
Electronic ISSN: 1475-2875
DOI: https://doi.org/10.1186/s12936-017-2006-6

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