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Published in: Malaria Journal 1/2016

Open Access 01-12-2016 | Research

Malaria incidence in Myanmar 2005–2014: steady but fragile progress towards elimination

Authors: Thet Thet Mu, Aye Aye Sein, Tint Tint Kyi, Myo Min, Ne Myo Aung, Nicholas M. Anstey, Myat Phone Kyaw, Chit Soe, Mar Mar Kyi, Josh Hanson

Published in: Malaria Journal | Issue 1/2016

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Abstract

Background

There has been an impressive recent reduction in the global incidence of malaria, but the development of artemisinin resistance in the Greater Mekong Region threatens this progress. Increasing artemisinin resistance is particularly important in Myanmar, as it is the country in the Greater Mekong Region with the greatest malaria burden. If malaria is to be eliminated in the region, it is essential to define the spatial and temporal epidemiology of the disease in Myanmar to inform control strategies optimally.

Results

Between the years 2005 and 2014 there was an 81.1 % decline in the reported annual incidence of malaria in Myanmar (1341.8 cases per 100,000 population to 253.3 cases per 100,000 population). In the same period, there was a 93.5 % decline in reported annual mortality from malaria (3.79 deaths per 100,000 population to 0.25 deaths per 100,000 population) and a 87.2 % decline in the proportion of hospitalizations due to malaria (7.8 to 1.0 %). Chin State had the highest reported malaria incidence and mortality at the end of the study period, although socio-economic and geographical factors appear a more likely explanation for this finding than artemisinin resistance. The reduced malaria burden coincided with significant upscaling of disease control measures by the national government with support from international partners. These programmes included the training and deployment of over 40,000 community health care workers, the coverage of over 60 % of the at-risk population with insecticide-treated bed nets and significant efforts to improve access to artemesinin-based combination treatment. Beyond these malaria-specific programmes, increased general investment in the health sector, changing population demographics and deforestation are also likely to have contributed to the decline in malaria incidence seen over this time.

Conclusions

There has been a dramatic fall in the burden of malaria in Myanmar since 2005. However, with the rise of artemisinin resistance, continued political, financial and scientific commitment is required if the ambitious goal of malaria elimination in the country is to be realized.
Literature
1.
go back to reference WHO. World Malaria Report 2015. Geneva: World Health Organization; 2015. WHO. World Malaria Report 2015. Geneva: World Health Organization; 2015.
2.
go back to reference WHO. Strategy for malaria elimination in the greater Mekong subregion (2015–2030). World Health Organization Regional Office for the Western Pacific; 2015. WHO. Strategy for malaria elimination in the greater Mekong subregion (2015–2030). World Health Organization Regional Office for the Western Pacific; 2015.
3.
go back to reference Worrall E, Basu S, Hanson K. Is malaria a disease of poverty? A review of the literature. Trop Med Int Health. 2005;10:1047–59.CrossRefPubMed Worrall E, Basu S, Hanson K. Is malaria a disease of poverty? A review of the literature. Trop Med Int Health. 2005;10:1047–59.CrossRefPubMed
4.
go back to reference Smith C, Whittaker M. Beyond mobile populations: a critical review of the literature on malaria and population mobility and suggestions for future directions. Malar J. 2014;13:307.CrossRefPubMedPubMedCentral Smith C, Whittaker M. Beyond mobile populations: a critical review of the literature on malaria and population mobility and suggestions for future directions. Malar J. 2014;13:307.CrossRefPubMedPubMedCentral
5.
go back to reference Menard D, Khim N, Beghain J, Adegnika AA, Shafiul-Alam M, Amodu O, et al. A worldwide map of Plasmodium falciparum K13-propeller polymorphisms. N Engl J Med. 2016;374:2453–64.CrossRefPubMed Menard D, Khim N, Beghain J, Adegnika AA, Shafiul-Alam M, Amodu O, et al. A worldwide map of Plasmodium falciparum K13-propeller polymorphisms. N Engl J Med. 2016;374:2453–64.CrossRefPubMed
6.
go back to reference Tun KM, Imwong M, Lwin KM, Win AA, Hlaing TM, Hlaing T, et al. Spread of artemisinin-resistant Plasmodium falciparum in Myanmar: a cross-sectional survey of the K13 molecular marker. Lancet Infect Dis. 2015;15:415–21.CrossRefPubMedPubMedCentral Tun KM, Imwong M, Lwin KM, Win AA, Hlaing TM, Hlaing T, et al. Spread of artemisinin-resistant Plasmodium falciparum in Myanmar: a cross-sectional survey of the K13 molecular marker. Lancet Infect Dis. 2015;15:415–21.CrossRefPubMedPubMedCentral
7.
go back to reference Dondorp AM, Nosten F, Yi P, Das D, Phyo AP, Tarning J, et al. Artemisinin resistance in Plasmodium falciparum malaria. N Engl J Med. 2009;361:455–67.CrossRefPubMedPubMedCentral Dondorp AM, Nosten F, Yi P, Das D, Phyo AP, Tarning J, et al. Artemisinin resistance in Plasmodium falciparum malaria. N Engl J Med. 2009;361:455–67.CrossRefPubMedPubMedCentral
8.
go back to reference Hay SI, Okiro EA, Gething PW, Patil AP, Tatem AJ, Guerra CA, et al. Estimating the global clinical burden of Plasmodium falciparum malaria in 2007. PLoS Med. 2010;7:e1000290.CrossRefPubMedPubMedCentral Hay SI, Okiro EA, Gething PW, Patil AP, Tatem AJ, Guerra CA, et al. Estimating the global clinical burden of Plasmodium falciparum malaria in 2007. PLoS Med. 2010;7:e1000290.CrossRefPubMedPubMedCentral
10.
go back to reference Nyunt MH, Aye KM, Kyaw KT, Han SS, Aye TT, Wai KT, et al. Challenges encountered by local health volunteers in early diagnosis and prompt treatment of malaria in Myanmar artemisinin resistance containment zones. Malar J. 2016;15:308.CrossRefPubMedPubMedCentral Nyunt MH, Aye KM, Kyaw KT, Han SS, Aye TT, Wai KT, et al. Challenges encountered by local health volunteers in early diagnosis and prompt treatment of malaria in Myanmar artemisinin resistance containment zones. Malar J. 2016;15:308.CrossRefPubMedPubMedCentral
11.
go back to reference Lwin MM, Sudhinaraset M, San AK, Aung T. Improving malaria knowledge and practices in rural Myanmar through a village health worker intervention: a cross-sectional study. Malar J. 2014;13:5.CrossRefPubMedPubMedCentral Lwin MM, Sudhinaraset M, San AK, Aung T. Improving malaria knowledge and practices in rural Myanmar through a village health worker intervention: a cross-sectional study. Malar J. 2014;13:5.CrossRefPubMedPubMedCentral
12.
go back to reference Nyunt MH, Aye KM, Kyaw MP, Kyaw TT, Hlaing T, Oo K, et al. Challenges in universal coverage and utilization of insecticide-treated bed nets in migrant plantation workers in Myanmar. Malar J. 2014;13:211.CrossRefPubMedPubMedCentral Nyunt MH, Aye KM, Kyaw MP, Kyaw TT, Hlaing T, Oo K, et al. Challenges in universal coverage and utilization of insecticide-treated bed nets in migrant plantation workers in Myanmar. Malar J. 2014;13:211.CrossRefPubMedPubMedCentral
13.
go back to reference Aung T, White C, Montagu D, McFarland W, Hlaing T, Khin HS, et al. Improving uptake and use of malaria rapid diagnostic tests in the context of artemisinin drug resistance containment in eastern Myanmar: an evaluation of incentive schemes among informal private healthcare providers. Malar J. 2015;14:105.CrossRefPubMedPubMedCentral Aung T, White C, Montagu D, McFarland W, Hlaing T, Khin HS, et al. Improving uptake and use of malaria rapid diagnostic tests in the context of artemisinin drug resistance containment in eastern Myanmar: an evaluation of incentive schemes among informal private healthcare providers. Malar J. 2015;14:105.CrossRefPubMedPubMedCentral
14.
go back to reference Strategic framework for artemisinin resistance containment in Myanmar (MARC) 2011–2015. World Health Organization, South-East Asia Regional Office; 2011. Strategic framework for artemisinin resistance containment in Myanmar (MARC) 2011–2015. World Health Organization, South-East Asia Regional Office; 2011.
15.
go back to reference National Strategic Plan. Malaria prevention and control 2010–2016. Republic of the Union of Myanmar: Department of Health; 2014. National Strategic Plan. Malaria prevention and control 2010–2016. Republic of the Union of Myanmar: Department of Health; 2014.
16.
go back to reference Khin HS, Aung T, Thi A, White C. Oral artemisinin monotherapy removal from the private sector in Eastern Myanmar between 2012 and 2014. Malar J. 2016;15:286.CrossRefPubMedPubMedCentral Khin HS, Aung T, Thi A, White C. Oral artemisinin monotherapy removal from the private sector in Eastern Myanmar between 2012 and 2014. Malar J. 2016;15:286.CrossRefPubMedPubMedCentral
17.
go back to reference Drake TL, Kyaw SS, Kyaw MP, Smithuis FM, Day NP, White LJ, et al. Cost effectiveness and resource allocation of Plasmodium falciparum malaria control in Myanmar: a modelling analysis of bed nets and community health workers. Malar J. 2015;14:376.CrossRefPubMedPubMedCentral Drake TL, Kyaw SS, Kyaw MP, Smithuis FM, Day NP, White LJ, et al. Cost effectiveness and resource allocation of Plasmodium falciparum malaria control in Myanmar: a modelling analysis of bed nets and community health workers. Malar J. 2015;14:376.CrossRefPubMedPubMedCentral
18.
19.
go back to reference Spoorenberg T. Demographic changes in Myanmar since 1983: an examination of official data. Popul Dev Rev. 2013;39:309–24.CrossRef Spoorenberg T. Demographic changes in Myanmar since 1983: an examination of official data. Popul Dev Rev. 2013;39:309–24.CrossRef
20.
go back to reference Carrara VI, Lwin KM, Phyo AP, Ashley E, Wiladphaingern J, Sriprawat K, et al. Malaria burden and artemisinin resistance in the mobile and migrant population on the Thai–Myanmar border, 1999–2011: an observational study. PLoS Med. 2013;10:e1001398.CrossRefPubMedPubMedCentral Carrara VI, Lwin KM, Phyo AP, Ashley E, Wiladphaingern J, Sriprawat K, et al. Malaria burden and artemisinin resistance in the mobile and migrant population on the Thai–Myanmar border, 1999–2011: an observational study. PLoS Med. 2013;10:e1001398.CrossRefPubMedPubMedCentral
21.
go back to reference Kaung M, Kyi TT, Aung NM, Kyaw MP, Min M, Htet ZW, et al. The prognostic utility of bedside assessment of adults hospitalized with malaria in Myanmar: a retrospective analysis. Malar J. 2015;14:63.CrossRefPubMedPubMedCentral Kaung M, Kyi TT, Aung NM, Kyaw MP, Min M, Htet ZW, et al. The prognostic utility of bedside assessment of adults hospitalized with malaria in Myanmar: a retrospective analysis. Malar J. 2015;14:63.CrossRefPubMedPubMedCentral
22.
go back to reference Li S, Yin S, Wang J, Li X, Feng J. Shifting from control to elimination: analysis of malaria epidemiological characteristics in Tengchong County around China–Myanmar border, 2005–2014. Malar J. 2016;15:45.CrossRefPubMedPubMedCentral Li S, Yin S, Wang J, Li X, Feng J. Shifting from control to elimination: analysis of malaria epidemiological characteristics in Tengchong County around China–Myanmar border, 2005–2014. Malar J. 2016;15:45.CrossRefPubMedPubMedCentral
23.
go back to reference Phyo AP, Ashley EA, Anderson TJ, Bozdech Z, Carrara VI, Sriprawat K, et al. Declining efficacy of artemisinin combination therapy against P. falciparum malaria on the Thai–Myanmar border (2003–2013): the role of parasite genetic factors. Clin Infect Dis. 2016;63:784–91.CrossRefPubMedPubMedCentral Phyo AP, Ashley EA, Anderson TJ, Bozdech Z, Carrara VI, Sriprawat K, et al. Declining efficacy of artemisinin combination therapy against P. falciparum malaria on the Thai–Myanmar border (2003–2013): the role of parasite genetic factors. Clin Infect Dis. 2016;63:784–91.CrossRefPubMedPubMedCentral
24.
go back to reference Khin HS, Chen I, White C, Sudhinaraset M, McFarland W, Littrell M, et al. Availability and quality of anti-malarials among private sector outlets in Myanmar in 2012: results from a large, community-based, cross-sectional survey before a large-scale intervention. Malar J. 2015;14:269.CrossRefPubMedPubMedCentral Khin HS, Chen I, White C, Sudhinaraset M, McFarland W, Littrell M, et al. Availability and quality of anti-malarials among private sector outlets in Myanmar in 2012: results from a large, community-based, cross-sectional survey before a large-scale intervention. Malar J. 2015;14:269.CrossRefPubMedPubMedCentral
25.
go back to reference Landier J, Parker DM, Thu AM, Carrara VI, Lwin KM, Bonnington CA, et al. The role of early detection and treatment in malaria elimination. Malar J. 2016;15:363.CrossRefPubMedPubMedCentral Landier J, Parker DM, Thu AM, Carrara VI, Lwin KM, Bonnington CA, et al. The role of early detection and treatment in malaria elimination. Malar J. 2016;15:363.CrossRefPubMedPubMedCentral
26.
go back to reference Aung T, Lwin MM, Sudhinaraset M, Wei C. Rural and urban disparities in health-seeking for fever in Myanmar: findings from a probability-based household survey. Malar J. 2016;15:386.CrossRefPubMedPubMedCentral Aung T, Lwin MM, Sudhinaraset M, Wei C. Rural and urban disparities in health-seeking for fever in Myanmar: findings from a probability-based household survey. Malar J. 2016;15:386.CrossRefPubMedPubMedCentral
27.
go back to reference Smith Paintain L, Willey B, Kedenge S, Sharkey A, Kim J, Buj V, et al. Community health workers and stand-alone or integrated case management of malaria: a systematic literature review. Am J Trop Med Hyg. 2014;91:461–70.CrossRefPubMed Smith Paintain L, Willey B, Kedenge S, Sharkey A, Kim J, Buj V, et al. Community health workers and stand-alone or integrated case management of malaria: a systematic literature review. Am J Trop Med Hyg. 2014;91:461–70.CrossRefPubMed
28.
go back to reference Lengeler C. Insecticide-treated bed nets and curtains for preventing malaria. Cochrane Database Syst Rev. 2004;2:CD000363.PubMed Lengeler C. Insecticide-treated bed nets and curtains for preventing malaria. Cochrane Database Syst Rev. 2004;2:CD000363.PubMed
29.
go back to reference Bhatt S, Weiss DJ, Cameron E, Bisanzio D, Mappin B, Dalrymple U, et al. The effect of malaria control on Plasmodium falciparum in Africa between 2000 and 2015. Nature. 2015;526:207–11.CrossRefPubMedPubMedCentral Bhatt S, Weiss DJ, Cameron E, Bisanzio D, Mappin B, Dalrymple U, et al. The effect of malaria control on Plasmodium falciparum in Africa between 2000 and 2015. Nature. 2015;526:207–11.CrossRefPubMedPubMedCentral
30.
go back to reference Lin K, Aung S, Lwin S, Min H, Aye NN, Webber R. Promotion of insecticide-treated mosquito nets in Myanmar. South east Asian J Trop Med Public Health. 2000;31:444–7. Lin K, Aung S, Lwin S, Min H, Aye NN, Webber R. Promotion of insecticide-treated mosquito nets in Myanmar. South east Asian J Trop Med Public Health. 2000;31:444–7.
31.
go back to reference Nosten F, White NJ. Artemisinin-based combination treatment of falciparum malaria. Am J Trop Med Hyg. 2007;77(6 Suppl):181–92.PubMed Nosten F, White NJ. Artemisinin-based combination treatment of falciparum malaria. Am J Trop Med Hyg. 2007;77(6 Suppl):181–92.PubMed
32.
go back to reference Kyaw MP, Nyunt MH, Chit K, Aye MM, Aye KH, Lindegardh N, et al. Reduced susceptibility of Plasmodium falciparum to artesunate in southern Myanmar. PLoS ONE. 2013;8:e57689.CrossRefPubMedPubMedCentral Kyaw MP, Nyunt MH, Chit K, Aye MM, Aye KH, Lindegardh N, et al. Reduced susceptibility of Plasmodium falciparum to artesunate in southern Myanmar. PLoS ONE. 2013;8:e57689.CrossRefPubMedPubMedCentral
33.
go back to reference Fairhurst RM. High Antimalarial efficacy of dihydroartemisinin–piperaquine on the China–Myanmar border: the calm before the storm. Am J Trop Med Hyg. 2015;93:436–7.CrossRefPubMedPubMedCentral Fairhurst RM. High Antimalarial efficacy of dihydroartemisinin–piperaquine on the China–Myanmar border: the calm before the storm. Am J Trop Med Hyg. 2015;93:436–7.CrossRefPubMedPubMedCentral
34.
go back to reference Tumwebaze P, Conrad MD, Walakira A, LeClair N, Byaruhanga O, Nakazibwe C, et al. Impact of antimalarial treatment and chemoprevention on the drug sensitivity of malaria parasites isolated from ugandan children. Antimicrob Agents Chemother. 2015;59:3018–30.CrossRefPubMedPubMedCentral Tumwebaze P, Conrad MD, Walakira A, LeClair N, Byaruhanga O, Nakazibwe C, et al. Impact of antimalarial treatment and chemoprevention on the drug sensitivity of malaria parasites isolated from ugandan children. Antimicrob Agents Chemother. 2015;59:3018–30.CrossRefPubMedPubMedCentral
35.
go back to reference Wang Y, Yang Z, Yuan L, Zhou G, Parker D, Lee MC, et al. Clinical efficacy of dihydroartemisinin–piperaquine for the treatment of uncomplicated Plasmodium falciparum malaria at the China–Myanmar border. Am J Trop Med Hyg. 2015;93:577–83.CrossRefPubMedPubMedCentral Wang Y, Yang Z, Yuan L, Zhou G, Parker D, Lee MC, et al. Clinical efficacy of dihydroartemisinin–piperaquine for the treatment of uncomplicated Plasmodium falciparum malaria at the China–Myanmar border. Am J Trop Med Hyg. 2015;93:577–83.CrossRefPubMedPubMedCentral
36.
go back to reference Amaratunga C, Lim P, Suon S, Sreng S, Mao S, Sopha C, et al. Dihydroartemisinin–piperaquine resistance in Plasmodium falciparum malaria in Cambodia: a multisite prospective cohort study. Lancet Infect Dis. 2016;16:357–65.CrossRefPubMed Amaratunga C, Lim P, Suon S, Sreng S, Mao S, Sopha C, et al. Dihydroartemisinin–piperaquine resistance in Plasmodium falciparum malaria in Cambodia: a multisite prospective cohort study. Lancet Infect Dis. 2016;16:357–65.CrossRefPubMed
37.
go back to reference Thriemer K, Hong NV, Rosanas-Urgell A, Phuc BQ, Ha do M, Pockele E, et al. Delayed parasite clearance after treatment with dihydroartemisinin–piperaquine in Plasmodium falciparum malaria patients in central Vietnam. Antimicrob Agents Chemother. 2014;58:7049–55.CrossRefPubMedPubMedCentral Thriemer K, Hong NV, Rosanas-Urgell A, Phuc BQ, Ha do M, Pockele E, et al. Delayed parasite clearance after treatment with dihydroartemisinin–piperaquine in Plasmodium falciparum malaria patients in central Vietnam. Antimicrob Agents Chemother. 2014;58:7049–55.CrossRefPubMedPubMedCentral
38.
go back to reference Lun ZR, Ferreira PE, Fu LC. Artemisinin resistance in Plasmodium falciparum. Lancet Infect Dis. 2014;14:450–1.CrossRefPubMed Lun ZR, Ferreira PE, Fu LC. Artemisinin resistance in Plasmodium falciparum. Lancet Infect Dis. 2014;14:450–1.CrossRefPubMed
39.
go back to reference White NJ. Can new treatment developments combat resistance in malaria? Expert Opin Pharmacother. 2016;17:1303–7.CrossRefPubMed White NJ. Can new treatment developments combat resistance in malaria? Expert Opin Pharmacother. 2016;17:1303–7.CrossRefPubMed
40.
go back to reference Newby G, Hwang J, Koita K, Chen I, Greenwood B, von Seidlein L, et al. Review of mass drug administration for malaria and its operational challenges. Am J Trop Med Hyg. 2015;93:125–34.CrossRefPubMedPubMedCentral Newby G, Hwang J, Koita K, Chen I, Greenwood B, von Seidlein L, et al. Review of mass drug administration for malaria and its operational challenges. Am J Trop Med Hyg. 2015;93:125–34.CrossRefPubMedPubMedCentral
41.
go back to reference Homan T, Hiscox A, Mweresa CK, Masiga D, Mukabana WR, Oria P, et al. The effect of mass mosquito trapping on malaria transmission and disease burden (SolarMal): a stepped-wedge cluster-randomised trial. Lancet. 2016;388:1193–201.CrossRefPubMed Homan T, Hiscox A, Mweresa CK, Masiga D, Mukabana WR, Oria P, et al. The effect of mass mosquito trapping on malaria transmission and disease burden (SolarMal): a stepped-wedge cluster-randomised trial. Lancet. 2016;388:1193–201.CrossRefPubMed
43.
go back to reference East Asia’s Changing Urban Landscape. Measuring a decade of spatial growth. Washington, DC: The World Bank; 2015. East Asia’s Changing Urban Landscape. Measuring a decade of spatial growth. Washington, DC: The World Bank; 2015.
44.
go back to reference Wang C, Myint SW. Environmental concerns of deforestation in Myanmar 2001–2010. Remote Sens. 2016;8:728.CrossRef Wang C, Myint SW. Environmental concerns of deforestation in Myanmar 2001–2010. Remote Sens. 2016;8:728.CrossRef
45.
go back to reference Ool TT, Storch V, Becker N. Review of the anopheline mosquitoes of Myanmar. J Vector Ecol. 2004;29:21–40.PubMed Ool TT, Storch V, Becker N. Review of the anopheline mosquitoes of Myanmar. J Vector Ecol. 2004;29:21–40.PubMed
46.
go back to reference The 2014 Myanmar population and housing census. Department of Population. Ministry of Immigration and Population; 2015. The 2014 Myanmar population and housing census. Department of Population. Ministry of Immigration and Population; 2015.
48.
go back to reference Najera JA, Gonzalez-Silva M, Alonso PL. Some lessons for the future from the Global Malaria Eradication Programme (1955–1969). PLoS Med. 2011;8:e1000412.CrossRefPubMedPubMedCentral Najera JA, Gonzalez-Silva M, Alonso PL. Some lessons for the future from the Global Malaria Eradication Programme (1955–1969). PLoS Med. 2011;8:e1000412.CrossRefPubMedPubMedCentral
Metadata
Title
Malaria incidence in Myanmar 2005–2014: steady but fragile progress towards elimination
Authors
Thet Thet Mu
Aye Aye Sein
Tint Tint Kyi
Myo Min
Ne Myo Aung
Nicholas M. Anstey
Myat Phone Kyaw
Chit Soe
Mar Mar Kyi
Josh Hanson
Publication date
01-12-2016
Publisher
BioMed Central
Published in
Malaria Journal / Issue 1/2016
Electronic ISSN: 1475-2875
DOI
https://doi.org/10.1186/s12936-016-1567-0

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