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Malaria Journal
Published in: Malaria Journal 1/2016

Open Access 01-12-2016 | Review

Tying malaria and microRNAs: from the biology to future diagnostic perspectives

Authors: Mercedes Rubio, Quique Bassat, Xavier Estivill, Alfredo Mayor

Published in: Malaria Journal | Issue 1/2016

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Abstract

Symptoms caused by bacterial, viral and malarial infections usually overlap and aetiologic diagnosis is difficult. Patient management in low-resource countries with limited laboratory services has been based predominantly on clinical evaluation and syndromic approaches. However, such clinical assessment has limited accuracy both for identifying the likely aetiological cause and for the early recognition of patients who will progress to serious or fatal disease. Plasma-detectable biomarkers that rapidly and accurately diagnose severe infectious diseases could reduce morbidity and decrease the unnecessary use of usually scarce therapeutic drugs. The discovery of microRNAs (miRNAs) has opened exciting new avenues to identify blood biomarkers of organ-specific injury. This review assesses current knowledge on the relationship between malaria disease and miRNAs, and evaluates how future research might lead to the use of these small molecules for identifying patients with severe malaria disease and facilitate treatment decisions.
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Metadata
Title
Tying malaria and microRNAs: from the biology to future diagnostic perspectives
Authors
Mercedes Rubio
Quique Bassat
Xavier Estivill
Alfredo Mayor
Publication date
01-12-2016
Publisher
BioMed Central
Published in
Malaria Journal / Issue 1/2016
Electronic ISSN: 1475-2875
DOI
https://doi.org/10.1186/s12936-016-1222-9

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