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Cardiovascular Diabetology

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Open Access 01-12-2016 | Original investigation

Severely impaired microvascular reactivity in diabetic patients with an acute coronary syndrome

Authors: Nikolaos Östlund Papadogeorgos, Gun Jörneskog, Mattias Bengtsson, Thomas Kahan, Majid Kalani

Published in: Cardiovascular Diabetology | Issue 1/2016

Abstract

Background

Microvascular function is impaired in patients with stable coronary artery disease. The aim was to study microvascular function in patients with diabetes and acute coronary syndrome (ACS).

Methods

Microvascular function was evaluated in 83 patients by laser Doppler fluxmetry (LDF) [PU; perfusion unit, median (interquartile range)] measuring resting LDF and peak LDF following a six min heating of the skin to 44 °C at the foot, respectively. All patients with ACS and without previously known diabetes underwent oral glucose tolerance test. Thirty-nine patients with type 2 diabetes mellitus free from coronary artery disease served as controls.

Results

Peak LDF was significantly (P = 0.03) lower in patients with ACS and diabetes (n = 22; 72 (52)) and diabetes without coronary artery disease (n = 39; 69 (51)) as compared to patients with ACS without diabetes (n = 46; 97 (60)), and patients without ACS (n = 15; 140 (121)), respectively. Patients with ACS (n = 68) had significantly (P = 0.04) lower peak LDF (92 (49)) as compared to patients without ACS (n = 15) (140 (121)).

Conclusion

Microvascular reactivity is severely impaired in patients with diabetes and ACS. Diabetes has a major influence on microvascular function in patients with coronary artery disease.

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Title: Severely impaired microvascular reactivity in diabetic patients with an acute coronary syndrome
Authors: Nikolaos Östlund Papadogeorgos
Gun Jörneskog
Mattias Bengtsson
Thomas Kahan
Majid Kalani
Publication date: 01-12-2016
Publisher: BioMed Central
Published in: Cardiovascular Diabetology / Issue 1/2016
Electronic ISSN: 1475-2840
DOI: https://doi.org/10.1186/s12933-016-0385-6

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