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Respiratory Research
Published in: Respiratory Research 1/2020

01-12-2020 | Idiopathic Pulmonary Fibrosis | Review

Ongoing challenges in pulmonary fibrosis and insights from the nintedanib clinical programme

Authors: Claudia Valenzuela, Sebastiano Emanuele Torrisi, Nicolas Kahn, Manuel Quaresma, Susanne Stowasser, Michael Kreuter

Published in: Respiratory Research | Issue 1/2020

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Abstract

The approvals of nintedanib and pirfenidone changed the treatment paradigm in idiopathic pulmonary fibrosis (IPF), and increased our understanding of the underlying disease mechanisms. Nonetheless, many challenges and unmet needs remain in the management of patients with IPF and other progressive fibrosing interstitial lung diseases.
This review describes how the nintedanib clinical programme has helped to address some of these challenges. Data from this programme have informed changes to the IPF diagnostic guidelines, the timing of treatment initiation, and the assessment of disease progression. The use of nintedanib to treat patients with advanced lung function impairment, concomitant emphysema, patients awaiting lung transplantation and patients with IPF and lung cancer is discussed. The long-term use of nintedanib and an up-to-date summary of nintedanib in clinical practice are discussed. Directions for future research, namely emerging therapeutic options, precision medicine and other progressive fibrosing interstitial lung diseases, are described.
Further developments in these areas should continue to improve patient outcomes.
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Metadata
Title
Ongoing challenges in pulmonary fibrosis and insights from the nintedanib clinical programme
Authors
Claudia Valenzuela
Sebastiano Emanuele Torrisi
Nicolas Kahn
Manuel Quaresma
Susanne Stowasser
Michael Kreuter
Publication date
01-12-2020
Publisher
BioMed Central
Published in
Respiratory Research / Issue 1/2020
Electronic ISSN: 1465-993X
DOI
https://doi.org/10.1186/s12931-019-1269-6

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