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Respiratory Research
Published in: Respiratory Research 1/2018

Open Access 01-12-2018 | Review

The prostaglandin D2 receptor 2 pathway in asthma: a key player in airway inflammation

Authors: Christian Domingo, Oscar Palomares, David A. Sandham, Veit J. Erpenbeck, Pablo Altman

Published in: Respiratory Research | Issue 1/2018

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Abstract

Asthma is characterised by chronic airway inflammation, airway obstruction and hyper-responsiveness. The inflammatory cascade in asthma comprises a complex interplay of genetic factors, the airway epithelium, and dysregulation of the immune response.
Prostaglandin D2 (PGD2) is a lipid mediator, predominantly released from mast cells, but also by other immune cells such as TH2 cells and dendritic cells, which plays a significant role in the pathophysiology of asthma. PGD2 mainly exerts its biological functions via two G-protein-coupled receptors, the PGD2 receptor 1 (DP1) and 2 (DP2). The DP2 receptor is mainly expressed by the key cells involved in type 2 immune responses, including TH2 cells, type 2 innate lymphoid cells and eosinophils. The DP2 receptor pathway is a novel and important therapeutic target for asthma, because increased PGD2 production induces significant inflammatory cell chemotaxis and degranulation via its interaction with the DP2 receptor. This interaction has serious consequences in the pulmonary milieu, including the release of pro-inflammatory cytokines and harmful cationic proteases, leading to tissue remodelling, mucus production, structural damage, and compromised lung function. This review will discuss the importance of the DP2 receptor pathway and the current understanding of its role in asthma.
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Metadata
Title
The prostaglandin D2 receptor 2 pathway in asthma: a key player in airway inflammation
Authors
Christian Domingo
Oscar Palomares
David A. Sandham
Veit J. Erpenbeck
Pablo Altman
Publication date
01-12-2018
Publisher
BioMed Central
Published in
Respiratory Research / Issue 1/2018
Electronic ISSN: 1465-993X
DOI
https://doi.org/10.1186/s12931-018-0893-x

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