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Published in: Respiratory Research 1/2018

Open Access 01-12-2018 | Review

Molecular imaging of pulmonary diseases

Authors: Julien Dimastromatteo, Eric J. Charles, Victor E. Laubach

Published in: Respiratory Research | Issue 1/2018

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Abstract

Imaging holds an important role in the diagnosis of lung diseases. Along with clinical tests, noninvasive imaging techniques provide complementary and valuable information that enables a complete differential diagnosis. Various novel molecular imaging tools are currently under investigation aimed toward achieving a better understanding of lung disease physiopathology as well as early detection and accurate diagnosis leading to targeted treatment. Recent research on molecular imaging methods that may permit differentiation of the cellular and molecular components of pulmonary disease and monitoring of immune activation are detailed in this review. The application of molecular imaging to lung disease is currently in its early stage, especially compared to other organs or tissues, but future studies will undoubtedly reveal useful pulmonary imaging probes and imaging modalities.
Literature
1.
go back to reference Anderson CJ, Lewis JS. Current status and future challenges for molecular imaging. Philos Trans A Math Phys Eng Sci. 2017;375:20170023.CrossRefPubMed Anderson CJ, Lewis JS. Current status and future challenges for molecular imaging. Philos Trans A Math Phys Eng Sci. 2017;375:20170023.CrossRefPubMed
2.
go back to reference Dimastromatteo J, Brentnall T, Kelly KA. Imaging in pancreatic disease. Nat Rev Gastroenterol Hepatol. 2016;14:97–109.CrossRefPubMed Dimastromatteo J, Brentnall T, Kelly KA. Imaging in pancreatic disease. Nat Rev Gastroenterol Hepatol. 2016;14:97–109.CrossRefPubMed
5.
go back to reference Ambrosini V, Nicolini S, Caroli P, Nanni C, Massaro A, Marzola MC, et al. PET/CT imaging in different types of lung cancer: an overview. Eur J Radiol. 2012;81:988–1001.CrossRefPubMed Ambrosini V, Nicolini S, Caroli P, Nanni C, Massaro A, Marzola MC, et al. PET/CT imaging in different types of lung cancer: an overview. Eur J Radiol. 2012;81:988–1001.CrossRefPubMed
6.
go back to reference National Lung Screening Trial Research Team, Aberle DR, Adams AM, Berg CD, Black WC, Clapp JD, et al. Reduced lung-cancer mortality with low-dose computed tomographic screening. NEJM. 2011;365:395–409.CrossRef National Lung Screening Trial Research Team, Aberle DR, Adams AM, Berg CD, Black WC, Clapp JD, et al. Reduced lung-cancer mortality with low-dose computed tomographic screening. NEJM. 2011;365:395–409.CrossRef
7.
go back to reference Carson J, Finley DJ. Lung cancer staging: an overview of the new staging system and implications for radiographic clinical staging. Semin Roentgenol. 2011;46:187–93.CrossRefPubMedPubMedCentral Carson J, Finley DJ. Lung cancer staging: an overview of the new staging system and implications for radiographic clinical staging. Semin Roentgenol. 2011;46:187–93.CrossRefPubMedPubMedCentral
8.
go back to reference Bunn PA. Worldwide overview of the current status of lung cancer diagnosis and treatment. Arch Pathol Lab Med. 2012;136:1478–81.CrossRefPubMed Bunn PA. Worldwide overview of the current status of lung cancer diagnosis and treatment. Arch Pathol Lab Med. 2012;136:1478–81.CrossRefPubMed
9.
go back to reference Gould MK, Tang T, I-LA L, Lee J, Zheng C, Danforth KN, et al. Recent trends in the identification of incidental pulmonary nodules. Am J Respir Crit Care Med. 2015;192:1208–14.CrossRefPubMed Gould MK, Tang T, I-LA L, Lee J, Zheng C, Danforth KN, et al. Recent trends in the identification of incidental pulmonary nodules. Am J Respir Crit Care Med. 2015;192:1208–14.CrossRefPubMed
10.
go back to reference Schechter NR, Erwin WD, Yang DJ, Kim EE, Munden RF, Forster K, et al. Radiation dosimetry and biodistribution of (99m)Tc-ethylene dicysteine-deoxyglucose in patients with non-small-cell lung cancer. Eur J Nucl Med Mol Imaging. 2009;36:1583–91.CrossRefPubMedPubMedCentral Schechter NR, Erwin WD, Yang DJ, Kim EE, Munden RF, Forster K, et al. Radiation dosimetry and biodistribution of (99m)Tc-ethylene dicysteine-deoxyglucose in patients with non-small-cell lung cancer. Eur J Nucl Med Mol Imaging. 2009;36:1583–91.CrossRefPubMedPubMedCentral
11.
go back to reference Zhang YH, Bryant J, Kong FL, DF Y, Mendez R, Edmund Kim E, et al. Molecular imaging of mesothelioma with (99m)Tc-ECG and (68)Ga-ECG. J Biomed Biotechnol. 2012;2012:232863.PubMedPubMedCentral Zhang YH, Bryant J, Kong FL, DF Y, Mendez R, Edmund Kim E, et al. Molecular imaging of mesothelioma with (99m)Tc-ECG and (68)Ga-ECG. J Biomed Biotechnol. 2012;2012:232863.PubMedPubMedCentral
12.
go back to reference Shen G, Ma H, Pang F, Ren P, Kuang A. Correlations of 18F–FDG and 18F–FLT uptake on PET with Ki-67 expression in patients with lung cancer: a meta-analysis. Acta Radiol. 2017;Jan 1:284185117706609 [Epub ahead of print]. Shen G, Ma H, Pang F, Ren P, Kuang A. Correlations of 18F–FDG and 18F–FLT uptake on PET with Ki-67 expression in patients with lung cancer: a meta-analysis. Acta Radiol. 2017;Jan 1:284185117706609 [Epub ahead of print].
13.
go back to reference Iwata R, Furumoto S, Pascali C, Bogni A, Ishiwata K. Radiosynthesis ofO-[11C]methyl-L-tyrosine andO-[18F]Fluoromethyl-L-tyrosine as potential PET tracers for imaging amino acid transport. J Label Comp Radiopharm. 2003;46:555–66.CrossRef Iwata R, Furumoto S, Pascali C, Bogni A, Ishiwata K. Radiosynthesis ofO-[11C]methyl-L-tyrosine andO-[18F]Fluoromethyl-L-tyrosine as potential PET tracers for imaging amino acid transport. J Label Comp Radiopharm. 2003;46:555–66.CrossRef
14.
go back to reference Tsukada H, Sato K, Fukumoto D, Kakiuchi T. Evaluation of D-isomers of O-18F-fluoromethyl, O-18F-fluoroethyl and O-18F-fluoropropyl tyrosine as tumour imaging agents in mice. Eur J Nucl Med Mol Imaging. 2006;33:1017–24.CrossRefPubMed Tsukada H, Sato K, Fukumoto D, Kakiuchi T. Evaluation of D-isomers of O-18F-fluoromethyl, O-18F-fluoroethyl and O-18F-fluoropropyl tyrosine as tumour imaging agents in mice. Eur J Nucl Med Mol Imaging. 2006;33:1017–24.CrossRefPubMed
15.
go back to reference Saharinen P, Tammela T, Karkkainen MJ, Alitalo K. Lymphatic vasculature: development, molecular regulation and role in tumor metastasis and inflammation. Trends Immunol. 2004;25:387–95.CrossRefPubMed Saharinen P, Tammela T, Karkkainen MJ, Alitalo K. Lymphatic vasculature: development, molecular regulation and role in tumor metastasis and inflammation. Trends Immunol. 2004;25:387–95.CrossRefPubMed
16.
go back to reference Blood CH, Zetter BR. Tumor interactions with the vasculature: angiogenesis and tumor metastasis. Biochim Biophys Acta. 1990;1032:89–118.PubMed Blood CH, Zetter BR. Tumor interactions with the vasculature: angiogenesis and tumor metastasis. Biochim Biophys Acta. 1990;1032:89–118.PubMed
17.
go back to reference Sleeman JP, Thiele W. Tumor metastasis and the lymphatic vasculature. Int J Cancer. 2009;125:2747–56.CrossRefPubMed Sleeman JP, Thiele W. Tumor metastasis and the lymphatic vasculature. Int J Cancer. 2009;125:2747–56.CrossRefPubMed
18.
go back to reference Luo H, England CG, Graves SA, Sun H, Liu G, Nickles RJ, et al. PET imaging of VEGFR-2 expression in lung cancer with 64Cu-labeled Ramucirumab. J Nucl Med. 2016;57:285–90.CrossRefPubMed Luo H, England CG, Graves SA, Sun H, Liu G, Nickles RJ, et al. PET imaging of VEGFR-2 expression in lung cancer with 64Cu-labeled Ramucirumab. J Nucl Med. 2016;57:285–90.CrossRefPubMed
19.
go back to reference Yip C, Blower PJ, Goh V, Landau DB, Cook GJ. Molecular imaging of hypoxia in non-small-cell lung cancer. Eur J Nucl Med Mol Imaging. 2015;42:956–76.CrossRefPubMed Yip C, Blower PJ, Goh V, Landau DB, Cook GJ. Molecular imaging of hypoxia in non-small-cell lung cancer. Eur J Nucl Med Mol Imaging. 2015;42:956–76.CrossRefPubMed
20.
go back to reference Chia K, Fleming IN, Blower PJ. Hypoxia imaging with PET: which tracers and why? Nucl Med Commun. 2012;33:217–22.CrossRefPubMed Chia K, Fleming IN, Blower PJ. Hypoxia imaging with PET: which tracers and why? Nucl Med Commun. 2012;33:217–22.CrossRefPubMed
21.
go back to reference Lim M, Jablons DM. Matrix metalloproteinase expression in lung cancer. Lung Cancer. 2002:349–56. Lim M, Jablons DM. Matrix metalloproteinase expression in lung cancer. Lung Cancer. 2002:349–56.
22.
go back to reference Salaün M, Peng J, Hensley HH, Roder N, Flieder DB, Houlle-Crépin S, et al. MMP-13 in-vivo molecular imaging reveals early expression in lung adenocarcinoma. PLoS One. 2015;10:e0132960.CrossRefPubMedPubMedCentral Salaün M, Peng J, Hensley HH, Roder N, Flieder DB, Houlle-Crépin S, et al. MMP-13 in-vivo molecular imaging reveals early expression in lung adenocarcinoma. PLoS One. 2015;10:e0132960.CrossRefPubMedPubMedCentral
23.
go back to reference Keating JJ, Okusanya OT, De Jesus E, Judy R, Jiang J, Deshpande C, et al. Intraoperative molecular imaging of lung adenocarcinoma can identify residual tumor cells at the surgical margins. Mol Imaging Biol. 2016;18:209–18.CrossRefPubMedPubMedCentral Keating JJ, Okusanya OT, De Jesus E, Judy R, Jiang J, Deshpande C, et al. Intraoperative molecular imaging of lung adenocarcinoma can identify residual tumor cells at the surgical margins. Mol Imaging Biol. 2016;18:209–18.CrossRefPubMedPubMedCentral
25.
go back to reference Bellani G, Laffey JG, Pham T, Fan E, Brochard L, Esteban A, et al. Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries. JAMA. 2016;315:788.CrossRefPubMed Bellani G, Laffey JG, Pham T, Fan E, Brochard L, Esteban A, et al. Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries. JAMA. 2016;315:788.CrossRefPubMed
26.
go back to reference Pham T, Rubenfeld GD. Fifty years of research in ARDS.The epidemiology of acute respiratory distress syndrome. A 50th birthday review. Am J Respir Crit Care Med. 2017;195:860–70.CrossRefPubMed Pham T, Rubenfeld GD. Fifty years of research in ARDS.The epidemiology of acute respiratory distress syndrome. A 50th birthday review. Am J Respir Crit Care Med. 2017;195:860–70.CrossRefPubMed
27.
go back to reference ARDS Definition Task Force, Ranieri VM, Rubenfeld GD, Thompson BT, Ferguson ND, Caldwell E, et al. Acute respiratory distress syndrome: the berlin definition. JAMA. 2012:2526–33. ARDS Definition Task Force, Ranieri VM, Rubenfeld GD, Thompson BT, Ferguson ND, Caldwell E, et al. Acute respiratory distress syndrome: the berlin definition. JAMA. 2012:2526–33.
28.
go back to reference Alberti C, Brun-Buisson C, Burchardi H, Martin C, Goodman S, Artigas A, et al. Epidemiology of sepsis and infection in ICU patients from an international multicentre cohort study. Intensive Care Med. 2002;28:108–21.CrossRefPubMed Alberti C, Brun-Buisson C, Burchardi H, Martin C, Goodman S, Artigas A, et al. Epidemiology of sepsis and infection in ICU patients from an international multicentre cohort study. Intensive Care Med. 2002;28:108–21.CrossRefPubMed
29.
go back to reference Mizgerd JP. Acute lower respiratory tract infection. The New England journal of medicine. Massachusetts medical. Society. 2008;358:716–27. Mizgerd JP. Acute lower respiratory tract infection. The New England journal of medicine. Massachusetts medical. Society. 2008;358:716–27.
31.
go back to reference Armstrong GL, Conn LA, Pinner RW. Trends in infectious disease mortality in the United States during the 20th century. JAMA. 1999;281:61–6.CrossRefPubMed Armstrong GL, Conn LA, Pinner RW. Trends in infectious disease mortality in the United States during the 20th century. JAMA. 1999;281:61–6.CrossRefPubMed
32.
go back to reference Walker CM, Abbott GF, Greene RE, J-AO S, Vummidi D, Digumarthy SR. Imaging pulmonary infection: classic signs and patterns. Am J Roentgenol. 2014;202:479–92.CrossRef Walker CM, Abbott GF, Greene RE, J-AO S, Vummidi D, Digumarthy SR. Imaging pulmonary infection: classic signs and patterns. Am J Roentgenol. 2014;202:479–92.CrossRef
33.
go back to reference Schuster DM, Alazraki N. Gallium and other agents in diseases of the lung. Semin Nucl Med. 2002;32:193–211.CrossRefPubMed Schuster DM, Alazraki N. Gallium and other agents in diseases of the lung. Semin Nucl Med. 2002;32:193–211.CrossRefPubMed
34.
go back to reference Segall GM, McDougall IR. Diagnostic value of lung uptake of indium-111 oxine-labeled white blood cells. Am J Roentgenol. 1986;147:601–6.CrossRef Segall GM, McDougall IR. Diagnostic value of lung uptake of indium-111 oxine-labeled white blood cells. Am J Roentgenol. 1986;147:601–6.CrossRef
35.
go back to reference Love C, Tomas MB, Palestro CJ. Pulmonary activity on labelled leukocyte images: patterns of uptake and their significance. Nucl Med Commun. 2002;23:559–63.CrossRefPubMed Love C, Tomas MB, Palestro CJ. Pulmonary activity on labelled leukocyte images: patterns of uptake and their significance. Nucl Med Commun. 2002;23:559–63.CrossRefPubMed
36.
go back to reference Pullambhatla M, Tessier J, Beck G, Jedynak B, Wurthner JU, Pomper MG. [(125)I]FIAU imaging in a preclinical model of lung infection: quantification of bacterial load. Am J Nucl Med Mol Imaging. 2012;2:260–70.PubMedPubMedCentral Pullambhatla M, Tessier J, Beck G, Jedynak B, Wurthner JU, Pomper MG. [(125)I]FIAU imaging in a preclinical model of lung infection: quantification of bacterial load. Am J Nucl Med Mol Imaging. 2012;2:260–70.PubMedPubMedCentral
37.
go back to reference Zhang XM, Zhang HH, McLeroth P, Berkowitz RD, Mont MA, Stabin MG, et al. [(124)I]FIAU: Human dosimetry and infection imaging in patients with suspected prosthetic joint infection. Nucl Med Biol. 2016;43:273–9.CrossRefPubMed Zhang XM, Zhang HH, McLeroth P, Berkowitz RD, Mont MA, Stabin MG, et al. [(124)I]FIAU: Human dosimetry and infection imaging in patients with suspected prosthetic joint infection. Nucl Med Biol. 2016;43:273–9.CrossRefPubMed
38.
go back to reference Chen L, Wang Y, Cheng D, Liu X, Dou S, Liu G, et al. (99m)Tc-MORF oligomers specific for bacterial ribosomal RNA as potential specific infection imaging agents. Bioorg Med Chem. 2013;21:6523–30.CrossRefPubMed Chen L, Wang Y, Cheng D, Liu X, Dou S, Liu G, et al. (99m)Tc-MORF oligomers specific for bacterial ribosomal RNA as potential specific infection imaging agents. Bioorg Med Chem. 2013;21:6523–30.CrossRefPubMed
39.
go back to reference Jørgensen NP, Alstrup AKO, Mortensen FV, Knudsen K, Jakobsen S, Madsen LB, et al. Cholinergic PET imaging in infections and inflammation using (11)C-donepezil and (18)F-FEOBV. Eur J Nucl Med Mol Imaging. 2017;44:449–58.CrossRefPubMed Jørgensen NP, Alstrup AKO, Mortensen FV, Knudsen K, Jakobsen S, Madsen LB, et al. Cholinergic PET imaging in infections and inflammation using (11)C-donepezil and (18)F-FEOBV. Eur J Nucl Med Mol Imaging. 2017;44:449–58.CrossRefPubMed
40.
go back to reference Ferro-Flores G, Ocampo-Garcia BE, Melendez-Alafort L. Development of specific radiopharmaceuticals for infection imaging by targeting infectious micro-organisms. Curr Pharm Des. 2012;18:1098–106.CrossRefPubMed Ferro-Flores G, Ocampo-Garcia BE, Melendez-Alafort L. Development of specific radiopharmaceuticals for infection imaging by targeting infectious micro-organisms. Curr Pharm Des. 2012;18:1098–106.CrossRefPubMed
42.
go back to reference Langer O, Brunner M, Zeitlinger M, Ziegler S, Iler U M, Dobrozemsky G, et al. In vitro and in vivo evaluation of [18F]ciprofloxacin for the imaging of bacterial infections with PET. Eur J Nucl Med Mol Imaging. 2004;32:143–50.CrossRefPubMed Langer O, Brunner M, Zeitlinger M, Ziegler S, Iler U M, Dobrozemsky G, et al. In vitro and in vivo evaluation of [18F]ciprofloxacin for the imaging of bacterial infections with PET. Eur J Nucl Med Mol Imaging. 2004;32:143–50.CrossRefPubMed
43.
go back to reference Zhang J, Zhang S, Guo H, Wang X. Synthesis and biological evaluation of a novel 99mTc(CO)3 complex of ciprofloxacin dithiocarbamate as a potential agent to target infection. Bioorg Med Chem Lett. 2010;20:3781–4.CrossRefPubMed Zhang J, Zhang S, Guo H, Wang X. Synthesis and biological evaluation of a novel 99mTc(CO)3 complex of ciprofloxacin dithiocarbamate as a potential agent to target infection. Bioorg Med Chem Lett. 2010;20:3781–4.CrossRefPubMed
44.
go back to reference Milavetz G. Global surveillance, prevention and control of chronic respiratory diseases: a comprehensive approach global surveillance, prevention and control of chronic respiratory diseases: a comprehensive approach;edited by BousquetJean and KhaltaevNikolai. J Pharm Technol. 2008;24:122.CrossRef Milavetz G. Global surveillance, prevention and control of chronic respiratory diseases: a comprehensive approach global surveillance, prevention and control of chronic respiratory diseases: a comprehensive approach;edited by BousquetJean and KhaltaevNikolai. J Pharm Technol. 2008;24:122.CrossRef
45.
46.
go back to reference Vogelmeier CF, Criner GJ, Martinez FJ, Anzueto A, Barnes PJ, Bourbeau J, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive lung disease 2017 report. GOLD executive summary. Am J Respir Crit Care Med. 2017:557–82. Vogelmeier CF, Criner GJ, Martinez FJ, Anzueto A, Barnes PJ, Bourbeau J, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive lung disease 2017 report. GOLD executive summary. Am J Respir Crit Care Med. 2017:557–82.
47.
go back to reference Forey BA, Thornton AJ, Lee PN. Systematic review with meta-analysis of the epidemiological evidence relating smoking to COPD, chronic bronchitis and emphysema. Pulm Med. 2011;11:36.CrossRef Forey BA, Thornton AJ, Lee PN. Systematic review with meta-analysis of the epidemiological evidence relating smoking to COPD, chronic bronchitis and emphysema. Pulm Med. 2011;11:36.CrossRef
48.
go back to reference Mascalchi M, Diciotti S, Sverzellati N, Camiciottoli G, Ciccotosto C, Falaschi F, et al. Low agreement of visual rating for detailed quantification of pulmonary emphysema in whole-lung CT. Acta Radiol. 2012;53:53–60.CrossRefPubMed Mascalchi M, Diciotti S, Sverzellati N, Camiciottoli G, Ciccotosto C, Falaschi F, et al. Low agreement of visual rating for detailed quantification of pulmonary emphysema in whole-lung CT. Acta Radiol. 2012;53:53–60.CrossRefPubMed
50.
go back to reference McCracken JL, Veeranki SP, Ameredes BT, Calhoun WJ. Diagnosis and Management of Asthma in adults: a review. JAMA. 2017;318:279–90.CrossRefPubMed McCracken JL, Veeranki SP, Ameredes BT, Calhoun WJ. Diagnosis and Management of Asthma in adults: a review. JAMA. 2017;318:279–90.CrossRefPubMed
51.
go back to reference James A, Mauad T, Abramson M, Green F. Airway smooth muscle hypertrophy and hyperplasia in asthma. Am J Respir Crit Care Med. 2012;186:568–9.CrossRefPubMed James A, Mauad T, Abramson M, Green F. Airway smooth muscle hypertrophy and hyperplasia in asthma. Am J Respir Crit Care Med. 2012;186:568–9.CrossRefPubMed
52.
go back to reference Lane SJ, Lee TH. Mast cell effector mechanisms. J Allergy Clin Immunol. 1996;98:S67–71–discussionS71–2. Lane SJ, Lee TH. Mast cell effector mechanisms. J Allergy Clin Immunol. 1996;98:S67–71–discussionS71–2.
53.
go back to reference Robinson DS, Bentley AM, Hartnell A, Kay AB, Durham SR. Activated memory T helper cells in bronchoalveolar lavage fluid from patients with atopic asthma: relation to asthma symptoms, lung function, and bronchial responsiveness. Thorax. 1993;48:26–32.CrossRefPubMedPubMedCentral Robinson DS, Bentley AM, Hartnell A, Kay AB, Durham SR. Activated memory T helper cells in bronchoalveolar lavage fluid from patients with atopic asthma: relation to asthma symptoms, lung function, and bronchial responsiveness. Thorax. 1993;48:26–32.CrossRefPubMedPubMedCentral
55.
go back to reference Jögi J, Ekberg M, Jonson B, Bozovic G, Bajc M. Ventilation/perfusion SPECT in chronic obstructive pulmonary disease: an evaluation by reference to symptoms, spirometric lung function and emphysema, as assessed with HRCT. Eur J Nucl Med Mol Imaging. 2011;38:1344–52.CrossRefPubMed Jögi J, Ekberg M, Jonson B, Bozovic G, Bajc M. Ventilation/perfusion SPECT in chronic obstructive pulmonary disease: an evaluation by reference to symptoms, spirometric lung function and emphysema, as assessed with HRCT. Eur J Nucl Med Mol Imaging. 2011;38:1344–52.CrossRefPubMed
56.
go back to reference Jones HA, Marino PS, Shakur BH, Morrell NW. In vivo assessment of lung inflammatory cell activity in patients with COPD and asthma. Eur Respir J. 2003;21:567–73.CrossRefPubMed Jones HA, Marino PS, Shakur BH, Morrell NW. In vivo assessment of lung inflammatory cell activity in patients with COPD and asthma. Eur Respir J. 2003;21:567–73.CrossRefPubMed
57.
go back to reference Jones HA, Cadwallader KA, White JF, Uddin M, Peters AM, Chilvers ER. Dissociation between respiratory burst activity and deoxyglucose uptake in human neutrophil granulocytes: implications for interpretation of (18)F-FDG PET images. J Nucl Med. 2002;43:652–7.PubMed Jones HA, Cadwallader KA, White JF, Uddin M, Peters AM, Chilvers ER. Dissociation between respiratory burst activity and deoxyglucose uptake in human neutrophil granulocytes: implications for interpretation of (18)F-FDG PET images. J Nucl Med. 2002;43:652–7.PubMed
58.
go back to reference Subramanian DR, Jenkins L, Edgar R, Quraishi N, Stockley RA, Parr DG. Assessment of pulmonary neutrophilic inflammation in emphysema by quantitative positron emission. Tomography. 2012;186:1125–32. Subramanian DR, Jenkins L, Edgar R, Quraishi N, Stockley RA, Parr DG. Assessment of pulmonary neutrophilic inflammation in emphysema by quantitative positron emission. Tomography. 2012;186:1125–32.
59.
go back to reference Golestani R, Razavian M, Ye Y, Zhang J, Jung JJ, Toczek J, et al. Matrix metalloproteinase-targeted imaging of lung inflammation and remodeling. J Nucl Med. 2017;58:138–43.CrossRefPubMedPubMedCentral Golestani R, Razavian M, Ye Y, Zhang J, Jung JJ, Toczek J, et al. Matrix metalloproteinase-targeted imaging of lung inflammation and remodeling. J Nucl Med. 2017;58:138–43.CrossRefPubMedPubMedCentral
60.
go back to reference Ambrosini V, Zompatori M, De Luca F, Antonia D, Allegri V, Nanni C, et al. 68Ga-DOTANOC PET/CT allows somatostatin receptor imaging in idiopathic pulmonary fibrosis: preliminary results. J Nucl Med. 2010;51:1950–5.CrossRefPubMed Ambrosini V, Zompatori M, De Luca F, Antonia D, Allegri V, Nanni C, et al. 68Ga-DOTANOC PET/CT allows somatostatin receptor imaging in idiopathic pulmonary fibrosis: preliminary results. J Nucl Med. 2010;51:1950–5.CrossRefPubMed
61.
go back to reference John AE, Luckett JC, Tatler AL, Awais RO, Desai A, Habgood A, et al. Preclinical SPECT/CT imaging of αvβ6 integrins for molecular stratification of idiopathic pulmonary fibrosis. J Nucl Med. 2013;54:2146–52.CrossRefPubMed John AE, Luckett JC, Tatler AL, Awais RO, Desai A, Habgood A, et al. Preclinical SPECT/CT imaging of αvβ6 integrins for molecular stratification of idiopathic pulmonary fibrosis. J Nucl Med. 2013;54:2146–52.CrossRefPubMed
62.
go back to reference Yusen RD, Edwards LB, Kucheryavaya AY, Benden C, Dipchand AI, Goldfarb SB, et al. The registry of the International Society for Heart and Lung Transplantation: thirty-second official adult lung and heart-lung transplantation report--2015; focus theme: early graft failure. J Heart Lung Transplant. 2015;34:1264–77.CrossRefPubMed Yusen RD, Edwards LB, Kucheryavaya AY, Benden C, Dipchand AI, Goldfarb SB, et al. The registry of the International Society for Heart and Lung Transplantation: thirty-second official adult lung and heart-lung transplantation report--2015; focus theme: early graft failure. J Heart Lung Transplant. 2015;34:1264–77.CrossRefPubMed
63.
go back to reference Valapour M, Paulson K, Smith JM, Hertz MI, Skeans MA, Heubner BM, et al. OPTN/SRTR 2011 Annual Data Report: lung. Am J Transplant. 2013;13(Suppl 1):149–77.CrossRefPubMed Valapour M, Paulson K, Smith JM, Hertz MI, Skeans MA, Heubner BM, et al. OPTN/SRTR 2011 Annual Data Report: lung. Am J Transplant. 2013;13(Suppl 1):149–77.CrossRefPubMed
64.
go back to reference Charles EJ, Huerter ME, Wagner CE, Sharma AK, Zhao Y, Stoler MH, et al. Donation after circulatory death lungs transplantable up to six hours after ex vivo lung perfusion. Ann Thorac Surg. 2016;102:1845–53.CrossRefPubMedPubMedCentral Charles EJ, Huerter ME, Wagner CE, Sharma AK, Zhao Y, Stoler MH, et al. Donation after circulatory death lungs transplantable up to six hours after ex vivo lung perfusion. Ann Thorac Surg. 2016;102:1845–53.CrossRefPubMedPubMedCentral
65.
go back to reference Cypel M, Levvey B, Van Raemdonck D, Erasmus M, Dark J, Love R, et al. International Society for Heart and Lung Transplantation donation after circulatory death registry report. J Heart Lung Transplant. 2015;34:1278–82.CrossRefPubMed Cypel M, Levvey B, Van Raemdonck D, Erasmus M, Dark J, Love R, et al. International Society for Heart and Lung Transplantation donation after circulatory death registry report. J Heart Lung Transplant. 2015;34:1278–82.CrossRefPubMed
66.
go back to reference Porteous MK, Diamond JM, Christie JD. Primary graft dysfunction: lessons learned about the first 72 h after lung transplantation. Curr Opin Organ Transplant. 2015;20:506–14.CrossRefPubMedPubMedCentral Porteous MK, Diamond JM, Christie JD. Primary graft dysfunction: lessons learned about the first 72 h after lung transplantation. Curr Opin Organ Transplant. 2015;20:506–14.CrossRefPubMedPubMedCentral
68.
go back to reference Sharma AK, Lapar DJ, Zhao Y, Li L, Lau CL, Kron IL, et al. Natural killer T cell-derived IL-17 mediates lung ischemia-reperfusion injury. Am J Respir Crit Care Med. 2011;183:1539–49.CrossRefPubMedPubMedCentral Sharma AK, Lapar DJ, Zhao Y, Li L, Lau CL, Kron IL, et al. Natural killer T cell-derived IL-17 mediates lung ischemia-reperfusion injury. Am J Respir Crit Care Med. 2011;183:1539–49.CrossRefPubMedPubMedCentral
69.
go back to reference Sharma AK, Fernandez LG, Awad AS, Kron IL, Laubach VE. Proinflammatory response of alveolar epithelial cells is enhanced by alveolar macrophage-produced TNF-alpha during pulmonary ischemia-reperfusion injury. Am J Physiol Lung Cell Mol Physiol. 2007;293:L105–13.CrossRefPubMed Sharma AK, Fernandez LG, Awad AS, Kron IL, Laubach VE. Proinflammatory response of alveolar epithelial cells is enhanced by alveolar macrophage-produced TNF-alpha during pulmonary ischemia-reperfusion injury. Am J Physiol Lung Cell Mol Physiol. 2007;293:L105–13.CrossRefPubMed
70.
go back to reference Fiser SM, Tribble CG, Long SM, Kaza AK, Cope JT, Laubach VE, et al. Lung transplant reperfusion injury involves pulmonary macrophages and circulating leukocytes in a biphasic response. J Thorac Cardiovasc Surg. 2001;121:1069–75.CrossRefPubMed Fiser SM, Tribble CG, Long SM, Kaza AK, Cope JT, Laubach VE, et al. Lung transplant reperfusion injury involves pulmonary macrophages and circulating leukocytes in a biphasic response. J Thorac Cardiovasc Surg. 2001;121:1069–75.CrossRefPubMed
71.
go back to reference Fiser SM, Tribble CG, Long SM, Kaza AK, Kern JA, Jones DR, et al. Ischemia-reperfusion injury after lung transplantation increases risk of late bronchiolitis obliterans syndrome. Ann Thorac Surg. 2002;73:1041–7.CrossRefPubMed Fiser SM, Tribble CG, Long SM, Kaza AK, Kern JA, Jones DR, et al. Ischemia-reperfusion injury after lung transplantation increases risk of late bronchiolitis obliterans syndrome. Ann Thorac Surg. 2002;73:1041–7.CrossRefPubMed
72.
go back to reference Royer P-J, Olivera-Botello G, Koutsokera A, Aubert J-D, Bernasconi E, Tissot A, et al. Chronic lung allograft dysfunction: a systematic review of mechanisms. Transplantation. 2016;100:1803–14.CrossRefPubMed Royer P-J, Olivera-Botello G, Koutsokera A, Aubert J-D, Bernasconi E, Tissot A, et al. Chronic lung allograft dysfunction: a systematic review of mechanisms. Transplantation. 2016;100:1803–14.CrossRefPubMed
73.
go back to reference Thabut G, Mal H, Cerrina J, Dartevelle P, Dromer C, Velly J-F, et al. Graft ischemic time and outcome of lung transplantation: a multicenter analysis. Am J Respir Crit Care Med. 2005;171:786–91.CrossRefPubMed Thabut G, Mal H, Cerrina J, Dartevelle P, Dromer C, Velly J-F, et al. Graft ischemic time and outcome of lung transplantation: a multicenter analysis. Am J Respir Crit Care Med. 2005;171:786–91.CrossRefPubMed
74.
go back to reference Liu Z, Zhao M, Zhu X, Furenlid LR, Chen Y-C, Barrett HH. Vivo dynamic imaging of myocardial cell death using 99mTc-labeled C2A domain of synaptotagmin I in a rat model of ischemia and reperfusion. Nucl Med Biol. 2007;34:907–15.CrossRefPubMedPubMedCentral Liu Z, Zhao M, Zhu X, Furenlid LR, Chen Y-C, Barrett HH. Vivo dynamic imaging of myocardial cell death using 99mTc-labeled C2A domain of synaptotagmin I in a rat model of ischemia and reperfusion. Nucl Med Biol. 2007;34:907–15.CrossRefPubMedPubMedCentral
75.
go back to reference Thukkani AK, Shoghi KI, Zhou D, Xu J, Chu W, Novak E, et al. PET imaging of in vivo caspase-3/7 activity following myocardial ischemia-reperfusion injury with the radiolabeled isatin sulfonamide analogue [(18)F]WC-4-116. Am J Nucl Med Mol Imaging. 2016;6:110–9.PubMedPubMedCentral Thukkani AK, Shoghi KI, Zhou D, Xu J, Chu W, Novak E, et al. PET imaging of in vivo caspase-3/7 activity following myocardial ischemia-reperfusion injury with the radiolabeled isatin sulfonamide analogue [(18)F]WC-4-116. Am J Nucl Med Mol Imaging. 2016;6:110–9.PubMedPubMedCentral
76.
go back to reference Liu Y, Li W, Luehmann HP, Zhao Y, Detering L, Sultan DH, et al. Noninvasive imaging of CCR2(+) cells in ischemia-reperfusion injury after lung transplantation. Am J Transplant. 2016;16:3016–23. Liu Y, Li W, Luehmann HP, Zhao Y, Detering L, Sultan DH, et al. Noninvasive imaging of CCR2(+) cells in ischemia-reperfusion injury after lung transplantation. Am J Transplant. 2016;16:3016–23.
77.
go back to reference Laubach VE, Charles EJ, Cordia MD, Sharma AK, Mehaffey JH, Zhang Y, et al. Use of a novel formyl peptide receptor ligand and noninvasive SPECT imaging to diagnose and monitor ischemia-reperfusion injury after lung transplantation. Am J Respir Crit Care Med. 2017;195(Meeting Abstracts):A7617. Laubach VE, Charles EJ, Cordia MD, Sharma AK, Mehaffey JH, Zhang Y, et al. Use of a novel formyl peptide receptor ligand and noninvasive SPECT imaging to diagnose and monitor ischemia-reperfusion injury after lung transplantation. Am J Respir Crit Care Med. 2017;195(Meeting Abstracts):A7617.
78.
go back to reference Roden AC, Aisner DL, Allen TC, Aubry MC, Barrios RJ, Beasley MB, et al. Diagnosis of acute cellular rejection and antibody-mediated rejection on lung transplant biopsies: a perspective from members of the pulmonary pathology society. Arch Pathol Lab Med. 2017;141:437–44.CrossRefPubMed Roden AC, Aisner DL, Allen TC, Aubry MC, Barrios RJ, Beasley MB, et al. Diagnosis of acute cellular rejection and antibody-mediated rejection on lung transplant biopsies: a perspective from members of the pulmonary pathology society. Arch Pathol Lab Med. 2017;141:437–44.CrossRefPubMed
79.
go back to reference Miller CA, Fildes JE, Ray SG, Doran H, Yonan N, Williams SG, et al. Non-invasive approaches for the diagnosis of acute cardiac allograft rejection. Heart. 2013;99:445–53.CrossRefPubMed Miller CA, Fildes JE, Ray SG, Doran H, Yonan N, Williams SG, et al. Non-invasive approaches for the diagnosis of acute cardiac allograft rejection. Heart. 2013;99:445–53.CrossRefPubMed
80.
go back to reference Chen DL, Wang X, Yamamoto S, Carpenter D, Engle JT, LI W, et al. Increased T cell glucose uptake reflects acute rejection in lung grafts. Am J Transplant. 2013;13:2540–9.CrossRefPubMedPubMedCentral Chen DL, Wang X, Yamamoto S, Carpenter D, Engle JT, LI W, et al. Increased T cell glucose uptake reflects acute rejection in lung grafts. Am J Transplant. 2013;13:2540–9.CrossRefPubMedPubMedCentral
Metadata
Title
Molecular imaging of pulmonary diseases
Authors
Julien Dimastromatteo
Eric J. Charles
Victor E. Laubach
Publication date
01-12-2018
Publisher
BioMed Central
Published in
Respiratory Research / Issue 1/2018
Electronic ISSN: 1465-993X
DOI
https://doi.org/10.1186/s12931-018-0716-0

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