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Respiratory Research
Published in: Respiratory Research 1/2017

Open Access 01-12-2017 | Review

The role of the endothelium in asthma and chronic obstructive pulmonary disease (COPD)

Authors: Clara E. Green, Alice M. Turner

Published in: Respiratory Research | Issue 1/2017

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Abstract

COPD and asthma are important chronic inflammatory disorders with a high associated morbidity. Much research has concentrated on the role of inflammatory cells, such as the neutrophil, in these diseases, but relatively little focus has been given to the endothelial tissue, through which inflammatory cells must transmigrate to reach the lung parenchyma and cause damage. There is evidence that there is an abnormal amount of endothelial tissue in COPD and asthma and that this tissue and its’ progenitor cells behave in a dysfunctional manner. This article reviews the evidence of the involvement of pulmonary endothelium in COPD and asthma and potential treatment options for this.
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Metadata
Title
The role of the endothelium in asthma and chronic obstructive pulmonary disease (COPD)
Authors
Clara E. Green
Alice M. Turner
Publication date
01-12-2017
Publisher
BioMed Central
Published in
Respiratory Research / Issue 1/2017
Electronic ISSN: 1465-993X
DOI
https://doi.org/10.1186/s12931-017-0505-1

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