Skip to main content
Top
Published in: BMC Complementary Medicine and Therapies 1/2016

Open Access 01-12-2015 | Research article

Long-term antihypertensive effects of far-infrared ray irradiated from wooden board in spontaneously hypertensive rats

Authors: Chien-Tsong Lin, Ming-Ju Lin, Yung-Pin Chen, Ko-Chao Lee, Kuo-Chin Huang, Shun-Fu Chang, Cheng-Nan Chen

Published in: BMC Complementary Medicine and Therapies | Issue 1/2016

Login to get access

Abstract

Background

Far-infrared ray (FIR) has been widely used in promoting health and has been shown to exert beneficial effects in vascular function. The non-thermal effect of FIR has been found to play a significant role in the protective effect on some vascular-related diseases, but its protective effects and use against hypertension have not been clearly presented.

Methods

In the present study, by using a wooden board coated with FIR-irradiated materials, we evaluated the long-term antihypertensive effect on spontaneously hypertensive rats (SHRs) in the environment in contact with the FIR-irradiated wooden board. SHRs were placed on the wooden board with or without FIR radiation for 4 weeks.

Results

The systolic blood pressure (BP) of SHRs undergoing different treatments was measured weekly using a tail-cuff method. FIR radiation significantly reduced the systolic BP of the SHRs along with a decreasing plasma level of angiotensin II and an increasing plasma level of bradykinin. In addition, long-term contact of FIR did not significantly affect the BP in normotensive Wistar Kyoto rats (WKYs).

Conclusions

Our results provided the evidence based on which FIR radiation could be considered an effective non-pharmacological choice for preventing hypertension.
Literature
1.
go back to reference van Vark LC, Bertrand M, Akkerhuis KM, Brugts JJ, Fox K, Mourad JJ, et al. Angiotensin-converting enzyme inhibitors reduce mortality in hypertension: a meta-analysis of randomized clinical trials of renin-angiotensin-aldosterone system inhibitors involving 158,998 patients. Eur Heart J. 2012;33:2088–97.CrossRefPubMedPubMedCentral van Vark LC, Bertrand M, Akkerhuis KM, Brugts JJ, Fox K, Mourad JJ, et al. Angiotensin-converting enzyme inhibitors reduce mortality in hypertension: a meta-analysis of randomized clinical trials of renin-angiotensin-aldosterone system inhibitors involving 158,998 patients. Eur Heart J. 2012;33:2088–97.CrossRefPubMedPubMedCentral
2.
go back to reference van Twist DJ, Kroon AA, de Leeuw PW. Angiotensin-(1-7) as a strategy in the treatment of hypertension? Curr Opin Nephrol Hypertens. 2014;23:480–6.CrossRefPubMed van Twist DJ, Kroon AA, de Leeuw PW. Angiotensin-(1-7) as a strategy in the treatment of hypertension? Curr Opin Nephrol Hypertens. 2014;23:480–6.CrossRefPubMed
3.
go back to reference Bernstein KE, Giani JF, Shen XZ, Gonzalez-Villalobos RA. Renal angiotensin-converting enzyme and blood pressure control. Curr Opin Nephrol Hypertens. 2014;23:106–12.CrossRefPubMedPubMedCentral Bernstein KE, Giani JF, Shen XZ, Gonzalez-Villalobos RA. Renal angiotensin-converting enzyme and blood pressure control. Curr Opin Nephrol Hypertens. 2014;23:106–12.CrossRefPubMedPubMedCentral
4.
go back to reference Giani JF, Janjulia T, Taylor B, Bernstein EA, Shah K, Shen XZ, et al. Renal generation of angiotensin II and the pathogenesis of hypertension. Curr Hypertens Rep. 2014;16:477.CrossRefPubMedPubMedCentral Giani JF, Janjulia T, Taylor B, Bernstein EA, Shah K, Shen XZ, et al. Renal generation of angiotensin II and the pathogenesis of hypertension. Curr Hypertens Rep. 2014;16:477.CrossRefPubMedPubMedCentral
5.
go back to reference Patel SK, Velkoska E, Freeman M, Wai B, Lancefield TF, Burrell LM. From gene to protein-experimental and clinical studies of ACE2 in blood pressure control and arterial hypertension. Front Physiol. 2014;5:227.CrossRefPubMedPubMedCentral Patel SK, Velkoska E, Freeman M, Wai B, Lancefield TF, Burrell LM. From gene to protein-experimental and clinical studies of ACE2 in blood pressure control and arterial hypertension. Front Physiol. 2014;5:227.CrossRefPubMedPubMedCentral
6.
go back to reference Lee KT. Quality and safety aspects of meat products as affected by various physical manipulations of packaging materials. Meat Sci. 2010;86:138–50.CrossRefPubMed Lee KT. Quality and safety aspects of meat products as affected by various physical manipulations of packaging materials. Meat Sci. 2010;86:138–50.CrossRefPubMed
7.
go back to reference Cho S, Shin MH, Kim YK, Seo JE, Lee YM, Park CH, et al. Effects of infrared radiation and heat on human skin aging in vivo. J Investig Dermatol Symp Proc. 2009;14:15–9.CrossRefPubMed Cho S, Shin MH, Kim YK, Seo JE, Lee YM, Park CH, et al. Effects of infrared radiation and heat on human skin aging in vivo. J Investig Dermatol Symp Proc. 2009;14:15–9.CrossRefPubMed
8.
go back to reference Lohr NL, Keszler A, Pratt P, Bienengraber M, Warltier DC, Hogg N. Enhancement of nitric oxide release from nitrosyl hemoglobin and nitrosyl myoglobin by red/near infrared radiation: potential role in cardioprotection. J Mol Cell Cardiol. 2009;47:256–63.CrossRefPubMedPubMedCentral Lohr NL, Keszler A, Pratt P, Bienengraber M, Warltier DC, Hogg N. Enhancement of nitric oxide release from nitrosyl hemoglobin and nitrosyl myoglobin by red/near infrared radiation: potential role in cardioprotection. J Mol Cell Cardiol. 2009;47:256–63.CrossRefPubMedPubMedCentral
9.
go back to reference Inoue S, Takemoto M, Chishaki A, Ide T, Nishizaka M, Miyazono M, et al. Leg heating using far infra-red radiation in patients with chronic heart failure acutely improves the hemodynamics, vascular endothelial function, and oxidative stress. Intern Med. 2012;51:2263–70.CrossRefPubMed Inoue S, Takemoto M, Chishaki A, Ide T, Nishizaka M, Miyazono M, et al. Leg heating using far infra-red radiation in patients with chronic heart failure acutely improves the hemodynamics, vascular endothelial function, and oxidative stress. Intern Med. 2012;51:2263–70.CrossRefPubMed
10.
go back to reference Toyokawa H, Matsui Y, Uhara J, Tsuchiya H, Teshima S, Nakanishi H, et al. Promotive effects of far-infrared ray on full-thickness skin wound healing in rats. Exp Biol Med (Maywood). 2003;228:724–9.CrossRef Toyokawa H, Matsui Y, Uhara J, Tsuchiya H, Teshima S, Nakanishi H, et al. Promotive effects of far-infrared ray on full-thickness skin wound healing in rats. Exp Biol Med (Maywood). 2003;228:724–9.CrossRef
11.
go back to reference Huang PH, Chen JW, Lin CP, Chen YH, Wang CH, Leu HB, et al. Far infra-red therapy promotes ischemia-induced angiogenesis in diabetic mice and restores high glucose-suppressed endothelial progenitor cell functions. Cardiovasc Diabetol. 2012;11:99.CrossRefPubMedPubMedCentral Huang PH, Chen JW, Lin CP, Chen YH, Wang CH, Leu HB, et al. Far infra-red therapy promotes ischemia-induced angiogenesis in diabetic mice and restores high glucose-suppressed endothelial progenitor cell functions. Cardiovasc Diabetol. 2012;11:99.CrossRefPubMedPubMedCentral
12.
go back to reference Udagawa Y, Ishigame H, Nagasawa H. Effects of hydroxyapatite in combination with far-infrared rays on spontaneous mammary tumorigenesis in SHN mice. Am J Chin Med. 2002;30:495–505.CrossRefPubMed Udagawa Y, Ishigame H, Nagasawa H. Effects of hydroxyapatite in combination with far-infrared rays on spontaneous mammary tumorigenesis in SHN mice. Am J Chin Med. 2002;30:495–505.CrossRefPubMed
13.
go back to reference Masuda A, Kihara T, Fukudome T, Shinsato T, Minagoe S, Tei C. The effects of repeated thermal therapy for two patients with chronic fatigue syndrome. J Psychosom Res. 2005;58:383–7.CrossRefPubMed Masuda A, Kihara T, Fukudome T, Shinsato T, Minagoe S, Tei C. The effects of repeated thermal therapy for two patients with chronic fatigue syndrome. J Psychosom Res. 2005;58:383–7.CrossRefPubMed
14.
go back to reference Bagnato GL, Miceli G, Atteritano M, Marino N, Bagnato GF. Far infrared emitting plaster in knee osteoarthritis: a single blinded, randomised clinical trial. Reumatismo. 2012;64:388–94.CrossRefPubMed Bagnato GL, Miceli G, Atteritano M, Marino N, Bagnato GF. Far infrared emitting plaster in knee osteoarthritis: a single blinded, randomised clinical trial. Reumatismo. 2012;64:388–94.CrossRefPubMed
15.
go back to reference Imamura M, Biro S, Kihara T. Repeated thermal therapy improves impaired vascular endothelial function in patients with coronary risk factors. J Am Coll Cardiol. 2001;38:108331088.CrossRef Imamura M, Biro S, Kihara T. Repeated thermal therapy improves impaired vascular endothelial function in patients with coronary risk factors. J Am Coll Cardiol. 2001;38:108331088.CrossRef
16.
go back to reference Lin CC, Liu XM, Peyton K, Wang H, Yang WC, Lin SJ, et al. Far infrared therapy inhibits vascular endothelial inflammation via the induction of heme oxygenase-1. Arterioscler Thromb Vasc Biol. 2008;28:739–45.CrossRefPubMedPubMedCentral Lin CC, Liu XM, Peyton K, Wang H, Yang WC, Lin SJ, et al. Far infrared therapy inhibits vascular endothelial inflammation via the induction of heme oxygenase-1. Arterioscler Thromb Vasc Biol. 2008;28:739–45.CrossRefPubMedPubMedCentral
17.
go back to reference Preston RA, Ledford M, Materson BJ, Baltodano NM, Memon A, Alonso A. Effects of severe, uncontrolled hypertension on endothelial activation: soluble vascular cell adhesion molecule-1, soluble intercellular adhesion molecule-1 and von Willebrand factor. J Hypertens. 2002;20:871–7.CrossRefPubMed Preston RA, Ledford M, Materson BJ, Baltodano NM, Memon A, Alonso A. Effects of severe, uncontrolled hypertension on endothelial activation: soluble vascular cell adhesion molecule-1, soluble intercellular adhesion molecule-1 and von Willebrand factor. J Hypertens. 2002;20:871–7.CrossRefPubMed
18.
go back to reference Zhang M, Wang G, Wang A, Tong W, Zhang Y. Association of hypertension with coexistence of abnormal metabolism and inflammation and endothelial dysfunction. Blood Press. 2013;22:151–7.CrossRefPubMed Zhang M, Wang G, Wang A, Tong W, Zhang Y. Association of hypertension with coexistence of abnormal metabolism and inflammation and endothelial dysfunction. Blood Press. 2013;22:151–7.CrossRefPubMed
19.
go back to reference Sato J, Kinugasa M, Satomi-Kobayashi S, Hatakeyama K, Knox AJ, Asada Y, et al. Family with sequence similarity 5, member C (FAM5C) increases leukocyte adhesion molecules in vascular endothelial cells: implication in vascular inflammation. PLoS One. 2014;9:e107236.CrossRefPubMedPubMedCentral Sato J, Kinugasa M, Satomi-Kobayashi S, Hatakeyama K, Knox AJ, Asada Y, et al. Family with sequence similarity 5, member C (FAM5C) increases leukocyte adhesion molecules in vascular endothelial cells: implication in vascular inflammation. PLoS One. 2014;9:e107236.CrossRefPubMedPubMedCentral
20.
go back to reference Tesfamariam B, DeFelice AF. Endothelial injury in the initiation and progression of vascular disorders. Vascul Pharmacol. 2007;46:229–37.CrossRefPubMed Tesfamariam B, DeFelice AF. Endothelial injury in the initiation and progression of vascular disorders. Vascul Pharmacol. 2007;46:229–37.CrossRefPubMed
21.
go back to reference Inanaga K, Ichiki T, Matsuura H, Miyazaki R, Hashimoto T, Takeda K, et al. Resveratrol attenuates angiotensin II-induced interleukin-6 expression and perivascular fibrosis. Hypertens Res. 2009;32:466–71.CrossRefPubMed Inanaga K, Ichiki T, Matsuura H, Miyazaki R, Hashimoto T, Takeda K, et al. Resveratrol attenuates angiotensin II-induced interleukin-6 expression and perivascular fibrosis. Hypertens Res. 2009;32:466–71.CrossRefPubMed
22.
go back to reference García-Tejedor A, Sánchez-Rivera L, Castelló-Ruiz M, Recio I, Salom JB, Manzanares P. Novel antihypertensive lactoferrin-derived peptides produced by Kluyveromyces marxianus: gastrointestinal stability profile and in vivo angiotensin I-converting enzyme (ACE) inhibition. J Agric Food Chem. 2014;62:1609–16.CrossRefPubMed García-Tejedor A, Sánchez-Rivera L, Castelló-Ruiz M, Recio I, Salom JB, Manzanares P. Novel antihypertensive lactoferrin-derived peptides produced by Kluyveromyces marxianus: gastrointestinal stability profile and in vivo angiotensin I-converting enzyme (ACE) inhibition. J Agric Food Chem. 2014;62:1609–16.CrossRefPubMed
23.
go back to reference Chen TC, Chien SJ, Kuo HC, Huang WS, Sheen JM, Lin TH, et al. High glucose-treated macrophages augment E-selectin expression in endothelial cells. J Biol Chem. 2011;286:25564–73.CrossRefPubMedPubMedCentral Chen TC, Chien SJ, Kuo HC, Huang WS, Sheen JM, Lin TH, et al. High glucose-treated macrophages augment E-selectin expression in endothelial cells. J Biol Chem. 2011;286:25564–73.CrossRefPubMedPubMedCentral
24.
go back to reference Xu L, Liu Y. Administration of telmisartan reduced systolic blood pressure and oxidative stress probably through the activation of PI3K/Akt/eNOS pathway and NO release in spontaneously hypertensive rats. Physiol Res. 2013;62:351–9.PubMed Xu L, Liu Y. Administration of telmisartan reduced systolic blood pressure and oxidative stress probably through the activation of PI3K/Akt/eNOS pathway and NO release in spontaneously hypertensive rats. Physiol Res. 2013;62:351–9.PubMed
25.
go back to reference Mugabo P, Raji IA. Effects of aqueous leaf extract of Asystasia gangetica on the blood pressure and heart rate in male spontaneously hypertensive Wistar rats. BMC Complement Altern Med. 2013;13:283.CrossRefPubMedPubMedCentral Mugabo P, Raji IA. Effects of aqueous leaf extract of Asystasia gangetica on the blood pressure and heart rate in male spontaneously hypertensive Wistar rats. BMC Complement Altern Med. 2013;13:283.CrossRefPubMedPubMedCentral
26.
go back to reference Wu L, Juurlink BH. Increased methylglyoxal and oxidative stress in hypertensive rat vascular smooth muscle cells. Hypertension. 2002;39:809–14.CrossRefPubMed Wu L, Juurlink BH. Increased methylglyoxal and oxidative stress in hypertensive rat vascular smooth muscle cells. Hypertension. 2002;39:809–14.CrossRefPubMed
27.
go back to reference Hultström M. Development of structural kidney damage in spontaneously hypertensive rats. J Hypertens. 2012;30:1087–91.CrossRefPubMed Hultström M. Development of structural kidney damage in spontaneously hypertensive rats. J Hypertens. 2012;30:1087–91.CrossRefPubMed
28.
go back to reference Pende A, Dallegri F. Renin-angiotensin antagonists: therapeutic effects beyond blood pressure control? Curr Pharm Des. 2012;18:1011–20.CrossRefPubMed Pende A, Dallegri F. Renin-angiotensin antagonists: therapeutic effects beyond blood pressure control? Curr Pharm Des. 2012;18:1011–20.CrossRefPubMed
29.
go back to reference Bakris G. Are there effects of renin-angiotensin system antagonists beyond blood pressure control? Am J Cardiol. 2010;105:21A–9.CrossRefPubMed Bakris G. Are there effects of renin-angiotensin system antagonists beyond blood pressure control? Am J Cardiol. 2010;105:21A–9.CrossRefPubMed
30.
go back to reference Marchesi C, Paradis P, Schiffrin EL. Role of the renin-angiotensin system in vascular inflammation. Trends Pharmacol Sci. 2008;29:367–74.CrossRefPubMed Marchesi C, Paradis P, Schiffrin EL. Role of the renin-angiotensin system in vascular inflammation. Trends Pharmacol Sci. 2008;29:367–74.CrossRefPubMed
31.
go back to reference Kobori H, Nangaku M, Navar LG, Nishiyama A. The intrarenal renin-angiotensin system: from physiology to the pathobiology of hypertension and kidney disease. Pharmacol Rev. 2007;59:251–87.CrossRefPubMed Kobori H, Nangaku M, Navar LG, Nishiyama A. The intrarenal renin-angiotensin system: from physiology to the pathobiology of hypertension and kidney disease. Pharmacol Rev. 2007;59:251–87.CrossRefPubMed
32.
go back to reference Unger T, Stoppelhaar M. Rationale for double renin-angiotensin-aldosterone system blockade. Am J Cardiol. 2007;100:25J–31.CrossRefPubMed Unger T, Stoppelhaar M. Rationale for double renin-angiotensin-aldosterone system blockade. Am J Cardiol. 2007;100:25J–31.CrossRefPubMed
33.
go back to reference Kim SM, Park S, Choue R. Effects of fermented milk peptides supplement on blood pressure and vascular function in spontaneously hypertensive rats. Food Sci Biotechnol. 2010;19:1409–13.CrossRef Kim SM, Park S, Choue R. Effects of fermented milk peptides supplement on blood pressure and vascular function in spontaneously hypertensive rats. Food Sci Biotechnol. 2010;19:1409–13.CrossRef
34.
go back to reference Sobajima M, Nozawa T, Ihori H, Shida T, Ohori T, Suzuki T, et al. Repeated sauna therapy improves myocardial perfusion in patients with chronically occluded coronary artery-related ischemia. Int J Cardiol. 2013;167:237–43.CrossRefPubMed Sobajima M, Nozawa T, Ihori H, Shida T, Ohori T, Suzuki T, et al. Repeated sauna therapy improves myocardial perfusion in patients with chronically occluded coronary artery-related ischemia. Int J Cardiol. 2013;167:237–43.CrossRefPubMed
35.
go back to reference Hwang S, Lee DH, Lee IK, Park YM, Jo I. Far-infrared radiation inhibits proliferation, migration, and angiogenesis of human umbilical vein endothelial cells by suppressing secretory clusterin levels. Cancer Lett. 2014;346:74–83.CrossRefPubMed Hwang S, Lee DH, Lee IK, Park YM, Jo I. Far-infrared radiation inhibits proliferation, migration, and angiogenesis of human umbilical vein endothelial cells by suppressing secretory clusterin levels. Cancer Lett. 2014;346:74–83.CrossRefPubMed
36.
go back to reference Hsu YH, Chen YC, Chen TH, Sue YM, Cheng TH, Chen JR, et al. Far-infrared therapy induces the nuclear translocation of PLZF which inhibits VEGF-induced proliferation in human umbilical vein endothelial cells. PLoS One. 2012;7:e30674.CrossRefPubMedPubMedCentral Hsu YH, Chen YC, Chen TH, Sue YM, Cheng TH, Chen JR, et al. Far-infrared therapy induces the nuclear translocation of PLZF which inhibits VEGF-induced proliferation in human umbilical vein endothelial cells. PLoS One. 2012;7:e30674.CrossRefPubMedPubMedCentral
37.
go back to reference Akasaki Y, Miyata M, Eto H, Shirasawa T, Hamada N, Ikeda Y, et al. Repeated thermal therapy up-regulates endothelial nitric oxide synthase and augments angiogenesis in a mouse model of hindlimb ischemia. Circ J. 2006;70:463–70.CrossRefPubMed Akasaki Y, Miyata M, Eto H, Shirasawa T, Hamada N, Ikeda Y, et al. Repeated thermal therapy up-regulates endothelial nitric oxide synthase and augments angiogenesis in a mouse model of hindlimb ischemia. Circ J. 2006;70:463–70.CrossRefPubMed
38.
go back to reference Meigs JB, Hu FB, Rifai N, Manson JE. Biomarkers of endothelial dysfunction and risk of type 2 diabetes mellitus. JAMA. 2004;291:1978–86.CrossRefPubMed Meigs JB, Hu FB, Rifai N, Manson JE. Biomarkers of endothelial dysfunction and risk of type 2 diabetes mellitus. JAMA. 2004;291:1978–86.CrossRefPubMed
39.
go back to reference Boulbou MS, Koukoulis GN, Makri ED, Petinaki EA, Gourgoulianis KI, Germenis AE. Circulating adhesion molecules levels in type 2 diabetes mellitus and hypertension. Int J Cardiol. 2005;98:39–44.CrossRefPubMed Boulbou MS, Koukoulis GN, Makri ED, Petinaki EA, Gourgoulianis KI, Germenis AE. Circulating adhesion molecules levels in type 2 diabetes mellitus and hypertension. Int J Cardiol. 2005;98:39–44.CrossRefPubMed
40.
go back to reference Kressel G, Trunz B, Bub A, Hülsmann O, Wolters M, Lichtinghagen R, et al. Systemic and vascular markers of inflammation in relation to metabolic syndrome and insulin resistance in adults with elevated atherosclerosis risk. Atherosclerosis. 2009;202:263–71.CrossRefPubMed Kressel G, Trunz B, Bub A, Hülsmann O, Wolters M, Lichtinghagen R, et al. Systemic and vascular markers of inflammation in relation to metabolic syndrome and insulin resistance in adults with elevated atherosclerosis risk. Atherosclerosis. 2009;202:263–71.CrossRefPubMed
41.
go back to reference De Caterina R, Ghiadoni L, Taddei S, Virdis A, Almerigogna F, Basta G, et al. Soluble E-selectin in essential hypertension: a correlate of vascular structural changes. Am J Hypertens. 2001;14:259–66.CrossRefPubMed De Caterina R, Ghiadoni L, Taddei S, Virdis A, Almerigogna F, Basta G, et al. Soluble E-selectin in essential hypertension: a correlate of vascular structural changes. Am J Hypertens. 2001;14:259–66.CrossRefPubMed
Metadata
Title
Long-term antihypertensive effects of far-infrared ray irradiated from wooden board in spontaneously hypertensive rats
Authors
Chien-Tsong Lin
Ming-Ju Lin
Yung-Pin Chen
Ko-Chao Lee
Kuo-Chin Huang
Shun-Fu Chang
Cheng-Nan Chen
Publication date
01-12-2015
Publisher
BioMed Central
Published in
BMC Complementary Medicine and Therapies / Issue 1/2016
Electronic ISSN: 2662-7671
DOI
https://doi.org/10.1186/s12906-016-1040-1

Other articles of this Issue 1/2016

BMC Complementary Medicine and Therapies 1/2016 Go to the issue