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BMC Oral Health
Published in: BMC Oral Health 1/2018

Open Access 01-12-2018 | Research article

The efficacy of platelet-rich fibrin as a scaffold in regenerative endodontic treatment: a retrospective controlled cohort study

Authors: Hongbing Lv, Yuemin Chen, Zhiyu Cai, Lishan Lei, Ming Zhang, Ronghui Zhou, Xiaojing Huang

Published in: BMC Oral Health | Issue 1/2018

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Abstract

Background

Blood Clot (BC) or platelet concentrates have been used as scaffold in regenerative endodontic treatment (RET). The aim of this retrospective study was to compare the performance of platelet-rich fibrin (PRF) with BC in inducing root development and periapical lesion healing after tooth revascularization.

Methods

Five patients receiving RET using PRF as a scaffold were matched 1:1 to a previous cohort of 5 patients who underwent tooth revascularization by provoking periapical bleeding. Clinical signs and symptoms were examined at follow-ups. Periapical lesion healing and root development were monitored radiographically. The resolution of clinical signs and symptoms as well as periapical radiolucency was observed in all patients (100%).

Results

Root elongation, dentinal wall thickening and apex closure were found in most cases (80% in both groups). There was no significant difference between the groups in terms of clinical sign resolution, root development and periapical healing.

Conclusions

Within the limits of this study, PRF achieved comparable outcomes to BC in terms of clinical sign and symptom resolution, periapical lesion healing and continued root development in RET.
Literature
1.
Iwaya SI, Ikawa M, Kubota M. Revascularization of an immature permanent tooth with apical periodontitis and sinus tract. Dent Traumatol. 2001;17:185–7.CrossRefPubMed
2.
Jung IY, Lee SJ, Hargreaves KM. Biologically based treatment of immature permanent teeth with pulpal necrosis: a case series. J Endod. 2008;34:876–87.CrossRefPubMed
3.
Torabinejad M, Turman M. Revitalization of tooth with necrotic pulp and open apex by using platelet-rich plasma: a case report. J Endod. 2011;37:265–8.CrossRefPubMed
4.
Chen MY, Chen KL, Chen CA, Tayebaty F, Rosenberg PA, Lin LM. Responses of immature permanent teeth with infected necrotic pulp tissue and apical periodontitis/abscess to revascularization procedures. Int Endod J. 2012;45:294–305.CrossRefPubMed
5.
Lei L, Chen Y, Zhou R, Huang X, Cai Z. Histologic and immunohistochemical findings of a human immature permanent tooth with apical periodontitis after regenerative endodontic treatment. J Endod. 2015;41:1172–9.CrossRefPubMed
6.
7.
8.
Scarparo RK, Dondoni L, Bottcher DE, Grecca FS, Rockenbach MI, Batista EL Jr. Response to intracanal medication in immature teeth with pulp necrosis: an experimental model in rat molars. J Endod. 2011;37:1069–73.CrossRefPubMed
9.
Ray HL Jr, Marcelino J, Braga R, Horwat R, Lisien M, Khaliq S. Long-term follow up of revascularization using platelet-rich fibrin. Dent Traumatol. 2016;32:80–4.CrossRefPubMed
10.
Rodriguez-Benitez S, Stambolsky C, Gutierrez-Perez JL, Torres-Lagares D, Segura-Egea JJ. Pulp revascularization of immature dog teeth with apical periodontitis using triantibiotic paste and platelet-rich plasma: a radiographic study. J Endod. 2015;41:1299–304.CrossRefPubMed
11.
12.
Hargreaves KM, Giesler T, Henry M, Wang Y. Regeneration potential of the young permanent tooth: what does the future hold? J Endod. 2008;34:S51–6.CrossRefPubMed
13.
Banchs F, Trope M. Revascularization of immature permanent teeth with apical periodontitis: new treatment protocol? J Endod. 2004;30:196–200.CrossRefPubMed
14.
Bezgin T, Yilmaz AD, Celik BN, Kolsuz ME, Sonmez H. Efficacy of platelet-rich plasma as a scaffold in regenerative endodontic treatment. J Endod. 2015;41:36–44.CrossRefPubMed
15.
Phillips JL, Weller RN, Kulild JC. The mental foramen: 2. Radiographic position in relation to the mandibular second premolar. J Endod. 1992;18:271–4.CrossRefPubMed
16.
Denio D, Torabinejad M, Bakland LK. Anatomical relationship of the mandibular canal to its surrounding structures in mature mandibles. J Endod. 1992;18:161–5.CrossRefPubMed
17.
Fishel D, Buchner A, Hershkowith A, Kaffe I. Roentgenologic study of the mental foramen. Oral Surg Oral Med Oral Pathol. 1976;41:682–6.CrossRefPubMed
18.
Knowles KI, Jergenson MA, Howard JH. Paresthesia associated with endodontic treatment of mandibular premolars. J Endod. 2003;29:768–70.CrossRefPubMed
19.
Scarano A, Di Carlo F, Quaranta A, Piattelli A. Injury of the inferior alveolar nerve after overfilling of the root canal with endodontic cement: a case report. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007;104:e56–9.CrossRefPubMed
20.
Mehta S, Watson JT. Platelet rich concentrate: basic science and current clinical applications. J Orthop Trauma. 2008;22:432–8.CrossRefPubMed
21.
Huang FM, Yang SF, Zhao JH, Chang YC. Platelet-rich fibrin increases proliferation and differentiation of human dental pulp cells. J Endod. 2010;36:1628–32.CrossRefPubMed
22.
Assoian RK, Grotendorst GR, Miller DM, Sporn MB. Cellular transformation by coordinated action of three peptide growth factors from human platelets. Nature. 1984;309:804–6.CrossRefPubMed
23.
Sachdeva GS, Sachdeva LT, Goel M, Bala S. Regenerative endodontic treatment of an immature tooth with a necrotic pulp and apical periodontitis using platelet-rich plasma (PRP) and mineral trioxide aggregate (MTA): a case report. Int Endod J. 2015;48:902–10.CrossRefPubMed
24.
Jadhav G, Shah N, Logani A. Revascularization with and without platelet-rich plasma in nonvital, immature, anterior teeth: a pilot clinical study. J Endod. 2012;38:1581–7.CrossRefPubMed
25.
Shivashankar VY, Johns DA, Vidyanath S, Kumar MR. Platelet rich fibrin in the revitalization of tooth with necrotic pulp and open apex. J Conserv Dent. 2012;15:395–8.CrossRefPubMedPubMedCentral
26.
27.
Keswani D, Pandey RK. Revascularization of an immature tooth with a necrotic pulp using platelet-rich fibrin: a case report. Int Endod J. 2013;46:1096–104.PubMed
28.
Johns DA, Shivashankar VY, Krishnamma S, Johns M. Use of photoactivated disinfection and platelet-rich fibrin in regenerative endodontics. J Conserv Dent. 2014;17:487–90.CrossRefPubMedPubMedCentral
29.
Jadhav GR, Shah D, Raghvendra SS. Autologus platelet rich fibrin aided revascularization of an immature, non-vital permanent tooth with apical periodontitis: a case report. J Nat Sci Biol Med. 2015;6:224–5.CrossRefPubMedPubMedCentral
30.
Yadav P, Pruthi PJ, Naval RR, Talwar S, Verma M. Novel use of platelet-rich fibrin matrix and MTA as an apical barrier in the management of a failed revascularization case. Dent Traumatol. 2015;31:328–31.CrossRefPubMed
31.
Narang I, Mittal N, Mishra N. A comparative evaluation of the blood clot, platelet-rich plasma, and platelet-rich fibrin in regeneration of necrotic immature permanent teeth: a clinical study. Contemp Clin Dent. 2015;6:63–8.CrossRefPubMedPubMedCentral
32.
Nolla CM. The development of permanent teeth. J Dent Child. 1960;27:254–66.
33.
Choukroun J, Diss A, Simonpieri A, Girard MO, Schoeffler C, Dohan SL, Dohan AJ, Mouhyi J, Dohan DM. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part V: histologic evaluations of PRF effects on bone allograft maturation in sinus lift. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101:299–303.CrossRefPubMed
34.
Zhu W, Zhu X, Huang GT, Cheung GS, Dissanayaka WL, Zhang C. Regeneration of dental pulp tissue in immature teeth with apical periodontitis using platelet-rich plasma and dental pulp cells. Int Endod J. 2013;46:962–70.CrossRefPubMed
35.
Zhang DD, Chen X, Bao ZF, Chen M, Ding ZJ, Zhong M. Histologic comparison between platelet-rich plasma and blood clot in regenerative endodontic treatment: an animal study. J Endod. 2014;40:1388–93.CrossRefPubMed
36.
Lovelace TW, Henry MA, Hargreaves KM, Diogenes A. Evaluation of the delivery of mesenchymal stem cells into the root canal space of necrotic immature teeth after clinical regenerative endodontic procedure. J Endod. 2011;37:133–8.CrossRefPubMed
37.
Yamada Y, Ueda M, Naiki T, Takahashi M, Hata K, Nagasaka T. Autogenous injectable bone for regeneration with mesenchymal stem cells and platelet-rich plasma: tissue-engineered bone regeneration. Tissue Eng. 2004;10:955–64.CrossRefPubMed
38.
Petrino JA, Boda KK, Shambarger S, Bowles WR, McClanahan SB. Challenges in regenerative endodontics: a case series. J Endod. 2010;36:536–41.CrossRefPubMed
39.
Ding RY, Cheung GS, Chen J, Yin XZ, Wang QQ, Zhang CF. Pulp revascularization of immature teeth with apical periodontitis: a clinical study. J Endod. 2009;35:745–9.CrossRefPubMed
40.
Iwaya S, Ikawa M, Kubota M. Revascularization of an immature permanent tooth with periradicular abscess after luxation. Dent Traumatol. 2011;27:55–8.CrossRefPubMed
41.
42.
Johns DA, Vidyanath S. Revitalization of tooth with necrotic pulp and open apex by using platelet-rich plasma: a case report. J Endod. 2011;37:743; author reply 43–4.CrossRefPubMed
Metadata
Title
The efficacy of platelet-rich fibrin as a scaffold in regenerative endodontic treatment: a retrospective controlled cohort study
Authors
Hongbing Lv
Yuemin Chen
Zhiyu Cai
Lishan Lei
Ming Zhang
Ronghui Zhou
Xiaojing Huang
Publication date
01-12-2018
Publisher
BioMed Central
Published in
BMC Oral Health / Issue 1/2018
Electronic ISSN: 1472-6831
DOI
https://doi.org/10.1186/s12903-018-0598-z

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