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BMC Oral Health
Published in: BMC Oral Health 1/2017

Open Access 01-12-2017 | Research article

Prevalence of oral manifestations in children and adolescents with cancer submitted to chemotherapy

Authors: Deise Berger Velten, Eliana Zandonade, Maria Helena Monteiro de Barros Miotto

Published in: BMC Oral Health | Issue 1/2017

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Abstract

Background

Oral complications may be observed during chemotherapy and are important side effects that may directly affect the anticancer treatment, even causing septicaemia in some cases. This research was done in order to evaluate changes in oral lesions during follow-up of children and adolescents in chemotherapy at Hospital Estadual Infantil Nossa Senhora da Glória (HEINSG).

Methods

The study design was longitudinal, 45 patients were evaluated and monitored for 1 month after the initiation of chemotherapy. Twenty-eight patients were male and 17 female, ranging from 3 months to 18 years old.

Results

The results show an increase in the number of mucositis cases and a decrease in xerostomia cases after the initiation of treatment, and other oral lesions were also found in low numbers.

Conclusions

It is possible to avoid oral complications by maintaining a good oral health, and reducing infectious outbreaks. It is also feasible to obtain an early diagnosis of, and treat these oral complications, preventing them from following a more severe clinical course that may negatively affect the individual’s treatment. This outcome requires the presence of a dental surgeon on the multidisciplinary cancer treatment team.
Literature
1.
Brasil Ministério da Saúde, Secretaria Nacional de Assistência à Saúde, Instituto Nacional do Câncer. Estimativa 2010: incidência do câncer no Brasil. Rio de Janeiro: INCA; 2009.
2.
3.
4.
Cheng KKF, Molassiotis A, Chang AM, Wai WC, Cheung SS. Evaluation of an oral care protocol intervention in the prevention of chemotherapy-induced oral mucositis in paediatric cancer patients. Eur J Cancer. 2001;37:2056–63.CrossRefPubMed
5.
Barbosa AM, Ribeiro DM, Caldo-Teixeira AS. Conhecimentos e práticas em saúde bucal com crianças hospitalizadas com câncer. Ciênc saúde coletiva. 2010;15(Supl.1):1113–22.CrossRef
6.
Sonis ST, Fazio RC, Fang L. Complicações bucais da terapia do câncer. In: Sonis ST, Fazio RC, Fang L, editors. Princípios e prática de medicina oral. 2nd ed. Rio de Janeiro: Guanabara Koogan; 1996. p. 358–83.
7.
Osterne RLV, Brito RGM, Nogueira RLM, Soares ECS, Alves APNN, Moura JFB, et al. Saúde bucal em pacientes portadores de neoplasias malignas: estudo clínico-epidemiológico e análise de necessidades odontológicas de 421 pacientes. Rev bras cancerol. 2008;54(3):221–26.
8.
Martins ACM, Caçador NP, Gaeti WP. Complicações bucais da quimioterapia antineoplásica. Acta Scientiarum. 2002;4(3):663–70.
9.
Sasada INV, Cancino CMH, Petersen RC, Hellwing I, Dillenburg CS. Prevenção de intercorrências estomatológicas em oncologia pediátrica. RFO. 2015;20(1):105–09.
10.
Lula ECO, Lula CEO, Alves CMCA, Lopes FF, Pereira AAP. Chemotherapy-induced oral complications in leukemic patients. Int J Pediatr Otorhinolaryngol. 2007;71:1681–85.CrossRef
11.
12.
13.
Feio M, Sapeta P. Xerostomia em cuidados paliativos. Acta Med Port. 2005;18:459–66.PubMed
14.
Jensen SB, Pedersen AM, Reibel J, et al. Xerostomia and hypofunction of the salivary glands in câncer therapy. Support Care Cancer. 2003;11:207–25.PubMed
15.
16.
Neville BW, Damm DD, Allen CM, Bouquot JE. Patologia oral & maxilofacial. 3rd ed. Rio de Janeiro: Ed. Elsevier; 2009.
17.
Ye Y, Carlsson G, Agholme MB, Sjoberg JK, Lindberg KP, Putsep K, et al. Pretherapeutic plasma pro- and anti-inflammatory mediators are related to high risk of oral mucositis in pediatric patients with acute leukemia: A prospective cohort study. Plos One. 2013;8(5):1–7.CrossRef
18.
Paiva MDEB, Biase RCCG, Moraes JJC, Ângelo AR, Honorato MCTM. Estudo retrospectivo das complicações orais decorrentes da terapia antineoplásica em pacientes do Hospital Napoleão Laureano, PB. Odontologia clín científ. 2007;6(1):51–5.
19.
Thomaz EBAF, Mouchrek Jr JCE, Silva AQ, Guerra RNM, Libério SA, Cruz MCFN. Longitudinal assessment of immunological and oral clinical conditions in patients undergoing anticancer treatment for leukemia. Int J Pediatr Otorhinolaryngol. 2013;77:1088–93.CrossRefPubMed
20.
Kreuger MRO, Savoldi LW, Hoffmann S, Diegoli NM. Complicações orais em pacientes em tratamento quimioterápico na UNACON, no município de Itajaí/SC. Revista da Faculdade de Odontologia de Lins. 2009; 21(1).
21.
Arisawa EAL, Silva CMOM, Cardoso CAC, Lemos NRPL, Pinto MC. Efeitos colaterais da terapia antitumoral em pacientes submetidos à quimio e à radioterapia. Rev biociên. 2005;11(1–2):55–61.
22.
Albuquerque RA, Morais VLL, Sobral APV. Avaliação clínica da frequência de complicações orais e sua relação com a qualidade de higiene bucal em pacientes pediátricos submetidos a tratamento antineoplásico. Arq Odontol. 2007;43(2):9–16.
23.
Hespanhol FL, Tinoco EMB, Teixeira HGC, Falabella MEV, Assis NMSP. Manifestações bucais em pacientes submetidos à quimioterapia. Ciência & Saúde Coletiva. 2010;15(Supl. 1):1085–94.CrossRef
24.
Alberth M, Majoros L, Kovalecz G, Borbás E, Szegedi I, Márton IJ, et al. Significance of oral cândida infections in children with cancer. Pathology Oncology Research. 2006;12(4):237–41.CrossRefPubMed
25.
Otmani N, Alami R, Hessissen L, Mokhtari A, Soulaymani A, Khattab. Determinants of severe oral mucositis in paediatric cancer patients: a prospective study. Int J Pediatr Otorhinolaryngol. 2011;21:210–16.
26.
Santos VI, Anbinder AL, Cavalcante ASR. Leucemia no paciente pediátrico: atuação odontológica. Cienc Odontol Bras. 2003;6(2):49–57.
27.
Cheng KKF, Goggins WB, Lee VWS, Thompson DR. Risk Factors for oral mucositis in children undergoing chemotherapy: A matched case–control study. Oral Oncol. 2008;44:1019–25.CrossRefPubMed
28.
Volpato LER, Silva TC, Oliveira TM, Sakai VT, Machado MAAM. Radiation therapy and chemotherapy-induced oral mucositis. Rev Bras Otorrinolaringol. 2007;73(4):562–68.CrossRef
29.
Qutob AF, GUE S, Revesz T, Logan RM, Keefe D. Prevention of oral mucositis in children receiving cancer therapy: A systematic review and evidence-based analysis. Oral Oncol. 2013;49:102–07.CrossRefPubMed
30.
Belfield PM, Dwyer AA. Oral complications of childhood cancer and its treatment: current best practice. Eur J Cancer. 2004;40:1035–41.CrossRefPubMed
31.
Plevová P. Prevention and treatment of chemotherapy and radiotherapy induced oral mucositis: a review. Oral Oncol. 1999;35:453–70.CrossRefPubMed
32.
Ribeiro Júnior O, Borba AM, Guimarães JJ. Prevenção e tratamento da mucosite bucal: o papel fundamental do cirurgião dentista: Revisão. Rev clín pesq odontol. 2010;6(1):57–62.
33.
Cruz LB, Ribeiro AS, Rech A, Rosa LGN, Castro Júnior CG, Brunetto AL. Influence of Low-Energy Laser in the Prevention of Oral Mucositis in Children with Cancer receiving Chemotherapy. Pediatr Blood Cancer. 2007;48:435–40.CrossRefPubMed
34.
Trindade AKF, De Biase RCCG, Filho GG, Pereira BC, Sousa EMD, Queiroga AS. Manifestações orais em pacientes pediátricos leucêmicos. Arq odontol. 2009;41(1):22–9.
35.
Ramirez-Amador V, Esquivel-Pedraza L, Mohar A, Reynoso-Gómez E, Volkow-Fernández P, Guarner J, et al. Chemotherapy-associated oral mucosal lesions in patients with leukaemia or lymphoma. Oral Oncol. 1996;32B(5):322–27.
Metadata
Title
Prevalence of oral manifestations in children and adolescents with cancer submitted to chemotherapy
Authors
Deise Berger Velten
Eliana Zandonade
Maria Helena Monteiro de Barros Miotto
Publication date
01-12-2017
Publisher
BioMed Central
Published in
BMC Oral Health / Issue 1/2017
Electronic ISSN: 1472-6831
DOI
https://doi.org/10.1186/s12903-016-0331-8

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