Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on sleep in brain health

LIVE: Thursday 2nd May 2024, 18:00-19:30 (CEST)

Quality sleep is essential for health. But what happens to our brains when sleep patterns are disturbed? Join our experts to explore the interplay between sleep disruption and neurological diseases, and the questions that you need to be asking your patients to help you prevent the harmful effects of sleep deprivation.
ADVANCED SEARCH
Log in
Top
BMC Endocrine Disorders
Published in: BMC Endocrine Disorders 1/2018

Open Access 01-12-2018 | Research article

Associations between ERα/β gene polymorphisms and osteoporosis susceptibility and bone mineral density in postmenopausal women: a systematic review and meta-analysis

Authors: Heping Zhu, Jiannong Jiang, Qiang Wang, Jun Zong, Liang Zhang, Tieliang Ma, Youjia Xu, Leiyan Zhang

Published in: BMC Endocrine Disorders | Issue 1/2018

Login to get access

Abstract

Background

Many studies have reported associations between estrogen receptor (ER) gene polymorphisms and postmenopausal osteoporosis (PMOP) risk and bone mineral density (BMD), but the results are controversial. The aim of the present meta-analysis is to verify the association between ERα and ERβ gene polymorphisms and osteoporosis susceptibility and BMD in postmenopausal women.

Methods

PubMed, EMBASE, Web of Science, the Cochrane Library and China WeiPu Library were searched. OR and WMD with 95% CI were calculated to assess the association.

Results

Overall, no significant association was observed between ERα XbaI, ERα PvuII and PMOP susceptibility in either overall, Caucasian or Asian populations. ERα G2014A was significantly associated with a decreased risk of PMOP in Caucasian populations. There was a significant association between ERβ RsaI and PMOP risk in both overall and Asian populations. Caucasian PMOP women with ERα XbaI XX and Xx genotypes had a higher LS Z value than women with xx genotype. ERα XbaI XX genotype was associated with increased FN BMD in overall and Caucasian populations, an increased FN Z value in Asians, and a decreased FN Z value in Caucasians. There was also a significant association between ERα XbaI Xx genotype and an increased FN Z value in either Asians or Caucasians. ERα PvuII PP genotype was associated with a low LS Z value in Caucasians and a low FN BMD and Z value in Asians. Pp genotype in PMOP women was significantly correlated with low LS BMD in overall populations, a low FN Z value in either overall, Caucasian or Asian populations.

Conclusion

Each ERα and ERβ gene polymorphism might have different impact on PMOP risk and BMD in various ethnicities.
Literature
1.
Gokosmanoglu F, Varim C, Atmaca A, Atmaca MH, Colak R. The effects of zoledronic acid treatment on depression and quality of life in women with postmenopausal osteoporosis: a clinical trial study. Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences. 2016;21:112.CrossRef
2.
Bandeira L, Bilezikian JP. Novel therapies for postmenopausal osteoporosis. Endocrinol Metab Clin N Am. 2017;46(1):207–19.CrossRef
3.
Eastell R, O'Neill TW, Hofbauer LC, Langdahl B, Reid IR, Gold DT, Cummings SR. Postmenopausal osteoporosis. Nature reviews Disease primers. 2016;2:16069.CrossRefPubMed
4.
Wensel TM, Iranikhah MM, Wilborn TW. Effects of denosumab on bone mineral density and bone turnover in postmenopausal women. Pharmacotherapy. 2011;31(5):510–23.CrossRefPubMed
5.
Paschalis EP, Gamsjaeger S, Hassler N, Fahrleitner-Pammer A, Dobnig H, Stepan JJ, Pavo I, Eriksen EF, Klaushofer K. Vitamin D and calcium supplementation for three years in postmenopausal osteoporosis significantly alters bone mineral and organic matrix quality. Bone. 2017;95:41–6.CrossRefPubMed
6.
Ebina K, Kashii M, Hirao M, Hashimoto J, Noguchi T, Koizumi K, Kitaguchi K, Matsuoka H, Iwahashi T, Tsukamoto Y, et al. Comparison of the effects of denosumab between a native vitamin D combination and an active vitamin D combination in patients with postmenopausal osteoporosis. J Bone Miner Metab. 2016;
7.
Safer U, Safer VB, Demir SO, Yanikoglu I. Effects of bisphosphonates and calcium plus vitamin-D supplements on cognitive function in postmenopausal osteoporosis section sign. Endocrine, metabolic & immune disorders drug targets. 2016;16(1):56–60.CrossRef
8.
Gennari L, Rotatori S, Bianciardi S, Nuti R, Merlotti D. Treatment needs and current options for postmenopausal osteoporosis. Expert Opin Pharmacother. 2016;17(8):1141–52.CrossRefPubMed
9.
Xie W, Ji L, Zhao T, Gao P. Identification of transcriptional factors and key genes in primary osteoporosis by DNA microarray. Medical science monitor : international medical journal of experimental and clinical research. 2015;21:1333–44.CrossRef
10.
Macari S, Ajay Sharma L, Wyatt A, Knowles P, Szawka RE, Garlet GP, Grattan DR, Dias GJ, Silva TA. Osteoprotective effects of estrogen in the maxillary bone depend on ERalpha. J Dent Res. 2016;95(6):689–96.CrossRefPubMed
11.
Shang DP, Lian HY, Fu DP, Wu J, Hou SS, Lu JM. Relationship between estrogen receptor 1 gene polymorphisms and postmenopausal osteoporosis of the spine in Chinese women. Genetics and molecular research : GMR. 2016;15(2)
12.
Wang ZR. Age diference of estrogen receptor gene polymorphisms in the elderly women with hip osteoporosis. Chin. J.of Tissue Engmeenng Res. 2015;19(7):991–5.
13.
Hai L, Jishen X, Bingpu C, Hailing H, Jinhua W, Jianhai C, xiaoyan F. Estrogen receptor- alpha gene PvuII, XbaI polymorphism, camellia oil and post-menopausal osteoporosis relevance in Guangxi Zhuang. Chinese. J Anat. 2014;37(5):581–4.
14.
Erdogan MO, Yildiz H, Artan S, Solak M, Tascioglu F, Dundar U, Eser B, Colak E. Association of estrogen receptor alpha and collagen type I alpha 1 gene polymorphisms with bone mineral density in postmenopausal women. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. 2011;22(4):1219–25.CrossRef
15.
Jeedigunta Y, Bhoomi Reddy PR, Kolla VK, Munshi A, Ananthapur V, Narasimulu G, Akka J. Association of estrogen receptor alpha gene polymorphisms with BMD and their affect on estradiol levels in pre- and postmenopausal women in south Indian population from Andhra Pradesh. Clin. Chim. Acta ; Int. J. of clin. Chem. 2010;411(7–8):597–600.CrossRef
16.
Durusu Tanriover M, Bora Tatar G, Uluturk TD, Dayangac Erden D, Tanriover A, Kilicarslan A, Oz SG, Erdem Yurter H, Sozen T, Sain Guven G. Evaluation of the effects of vitamin D receptor and estrogen receptor 1 gene polymorphisms on bone mineral density in postmenopausal women. Clin Rheumatol. 2010;29(11):1285–93.CrossRefPubMed
17.
Harslof T, Husted LB, Carstens M, Stenkjaer L, Langdahl BL. Genotypes and haplotypes of the estrogen receptor genes, but not the retinoblastoma-interacting zinc finger protein 1 gene, are associated with osteoporosis. Calcif Tissue Int. 2010;87(1):25–35.CrossRefPubMed
18.
Musumeci M, Vadala G, Tringali G, Insirello E, Roccazzello AM, Simpore J, Musumeci S. Genetic and environmental factors in human osteoporosis from sub-Saharan to Mediterranean areas. J Bone Miner Metab. 2009;27(4):424–34.CrossRefPubMed
19.
Perez A, Ulla M, Garcia B, Lavezzo M, Elias E, Binci M, Rivoira M, Centeno V, Alisio A, Tolosa de Talamoni N. Genotypes and clinical aspects associated with bone mineral density in argentine postmenopausal women. J Bone Miner Metab. 2008;26(4):358–65.CrossRefPubMed
20.
Ivanova JT, Doukova PB, Boyanov MA, Popivanov PR. PvuII and XbaI polymorphisms of the estrogen receptor gene and bone mineral density in a Bulgarian population sample. Hormones (Athens, Greece). 2007;6(1):36–43.
21.
Wang W, Fu SJ, Wang XS, Zhang YP, Wang SW, Zhong B. The relationship between ER gene polymorphisms and postmenopause osteoporosis of spine in southern Chinese women. Jurnal of Clinical Orthopsedics. 2006;9(6):562–5.
22.
Nam HS, Shin MH, Kweon SS, Park KS, Sohn SJ, Rhee JA, Choi JS, Son MH. Association of estrogen receptor-alpha gene polymorphisms with bone mineral density in postmenopausal Korean women. J Bone Miner Metab. 2005;23(1):84–9.CrossRefPubMed
23.
Qin YJ, Zhang ZL, Huang QR, He JW, Zhou Q, Hu YQ, Li M, Liu YJ. Association of ER alpha gene PvuII and XbaI polymorphisms and related factors with osteoporosis in postmenopausal women: a case-control study. Chin J Geriatr. 2004;23(6):380–3.
24.
Aerssens J, Dequeker J, Peeters J, Breemans S, Broos P, Boonen S. Polymorphisms of the VDR, ER and COLIA1 genes and osteoporotic hip fracture in elderly postmenopausal women. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. 2000;11(7):583–91.CrossRef
25.
Sonoda T, Takada J, Iba K, Asakura S, Yamashita T, Mori M. Interaction between ESRα polymorphisms and environmental factors in osteoporosis. J Orthop Res. 2012;30(10):1529–34.CrossRefPubMed
26.
Wajanavisit W, Suppachokmongkorn S, Woratanarat P, Ongphiphadhanakul B, Tawonsawatruk T. The association of bone mineral density and G2014A polymorphism in the estrogen receptor alpha gene in osteoporotic hip fracture in Thai population. Journal of the Medical Association of Thailand = Chotmaihet thangphaet. 2015;98(Suppl 8):S82–7.PubMed
27.
Gomez R, Magana JJ, Cisneros B, Perez-Salazar E, Faugeron S, Veliz D, Castro C, Rubio J, Casas L, Valdes-Flores M. Association of the estrogen receptor alpha gene polymorphisms with osteoporosis in the Mexican population. Clin Genet. 2007;72(6):574–81.CrossRefPubMed
28.
Ongphiphadhanakul B, Chanprasertyothin S, Payattikul P, Saetung S, Rajatanavin R. The implication of assessing a polymorphism in estrogen receptor alpha gene in the risk assessment of osteoporosis using a screening tool for osteoporosis in Asians. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. 2003;14(10):863–7.CrossRef
29.
Ongphiphadhanakul B, Chanprasertyothin S, Payattikul P, Saetung S, Piaseu N, Chailurkit L, Rajatanavin R. Association of a G2014A transition in exon 8 of the estrogen receptor-alpha gene with postmenopausal osteoporosis. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. 2001;12(12):1015–9.CrossRef
30.
Shoukry A, Shalaby SM, Etewa RL, Ahmed HS, Abdelrahman HM. Association of estrogen receptor beta and estrogen-related receptor alpha gene polymorphisms with bone mineral density in postmenopausal women. Mol Cell Biochem. 2015;405(1–2):23–31.CrossRefPubMed
31.
Huang HL, Tan HH, Chen BP, Li H, Xie JS, Zhao QZ. Correlation of polymorphism of estrogen receptor-β and camellia oil with post-menopausal osteoporosis in Zhuang women of Guangxi. Chinese Journal of Anatomy. 2015;03:323–325,343.
32.
Moron FJ, Mendoza N, Vazquez F, Molero E, Quereda F, Salinas A, Fontes J, Martinez-Astorquiza T, Sanchez-Borrego R, Ruiz A. Multilocus analysis of estrogen-related genes in Spanish postmenopausal women suggests an interactive role of ESR1, ESR2 and NRIP1 genes in the pathogenesis of osteoporosis. Bone. 2006;39(1):213–21.CrossRefPubMed
33.
Albagha OM, FE MG, Reid DM, Ralston SH. Estrogen receptor alpha gene polymorphisms and bone mineral density: haplotype analysis in women from the United Kingdom. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2001;16(1):128–34.CrossRef
34.
Kurt O, Yilmaz-Aydogan H, Uyar M, Isbir T, Seyhan MF, Can A. Evaluation of ERalpha and VDR gene polymorphisms in relation to bone mineral density in Turkish postmenopausal women. Mol Biol Rep. 2012;39(6):6723–30.CrossRefPubMed
35.
Kurabayashi T, Tomita M, Matsushita H, Yahata T, Honda A, Takakuwa K, Tanaka K. Association of vitamin D and estrogen receptor gene polymorphism with the effect of hormone replacement therapy on bone mineral density in Japanese women. Am J Obstet Gynecol. 1999;180(5):1115–20.CrossRefPubMed
36.
Ge JR, Zhu XX, Chen K. Effect of estrogen receptor gene Px haplotype on bone mineral density in female postmenopausal osteoporosis. Chin J Geriatr. 2006;25(6):416–9.
37.
Ge JR, Wang HM, Zhu XX, Chen K. Effect of PvuIIpolymorphisms of estrogen receptor gene on filtering risk factors in postmenopansal osteoporosis. Chin J Osteoporos. 2006;12(1):38–40.
38.
An SJ, Li E, Tong XX, Liu K, Zhao JS. Study on relationship between estrogen receptor gene polymorphism and syndrome differentiation typing of female postmenopausal osteoporosis in traditional Chinese medicine. Chinese Journal of Integrated Traditional and Western Medicine. 2000;20(12):907–10.PubMed
39.
Wang KJ, Shi DQ, Sun LS, Jiang X, Lu YY, Dai J, Chen DY, Xu ZH, Jiang Q. Association of estrogen receptor alpha gene polymorphisms with bone mineral density: a meta-analysis. Chin Med J. 2012;125(14):2589–97.PubMed
40.
Wang CL, Tang XY, Chen WQ, Su YX, Zhang CX, Chen YM. Association of estrogen receptor alpha gene polymorphisms with bone mineral density in Chinese women: a meta-analysis. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. 2007;18(3):295–305.CrossRef
41.
Ioannidis JP, Stavrou I, Trikalinos TA, Zois C, Brandi ML, Gennari L, Albagha O, Ralston SH, Tsatsoulis A. Association of polymorphisms of the estrogen receptor alpha gene with bone mineral density and fracture risk in women: a meta-analysis. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2002;17(11):2048–60.CrossRef
Metadata
Title
Associations between ERα/β gene polymorphisms and osteoporosis susceptibility and bone mineral density in postmenopausal women: a systematic review and meta-analysis
Authors
Heping Zhu
Jiannong Jiang
Qiang Wang
Jun Zong
Liang Zhang
Tieliang Ma
Youjia Xu
Leiyan Zhang
Publication date
01-12-2018
Publisher
BioMed Central
Published in
BMC Endocrine Disorders / Issue 1/2018
Electronic ISSN: 1472-6823
DOI
https://doi.org/10.1186/s12902-018-0230-x

Other articles of this Issue 1/2018

BMC Endocrine Disorders 1/2018 Go to the issue

Research article

The effects of synbiotic supplementation on hormonal status, biomarkers of inflammation and oxidative stress in subjects with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial

Case report

The clinical course and pathophysiological investigation of adolescent gestational diabetes insipidus: a case report

Research article

Vitamin D status in healthy black African adults at a tertiary hospital in Nairobi, Kenya: a cross sectional study

Research article

Associations among IGF-1, IGF2, IGF-1R, IGF-2R, IGFBP-3, insulin genetic polymorphisms and central precocious puberty in girls

Research article

Predictors of vascular complications among type 2 diabetes mellitus patients at University of Gondar Referral Hospital: a retrospective follow-up study

Research article

Retrospective assessment of the quality of diabetes care in a rural diabetes clinic in Western Kenya

ACC 2024 Congress Coverage

Cardiology Video

Highlights from the ACC 2024 Congress

Watch now

Watch official videos from the ACC congress summarizing key highlights from the last year in heart failure, cardiomyopathies, valvular disease, pulmonary vascular disease, and pediatric cardiology.

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

16-04-2024 Type 2 Diabetes News

Incentivised to exercise

11-04-2024 Lifestyle Modifications News

New intervention for STEMI-related cardiogenic shock

10-04-2024 Myocardial Infarction News

» View more highlights on the ACC 2024 congress hub page

Image Credits