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Open Access 01-12-2015 | Research article

Poor sleep quality is associated with increased arterial stiffness in Japanese patients with type 2 diabetes mellitus

Authors: Yusuke Osonoi, Tomoya Mita, Takeshi Osonoi, Miyoko Saito, Atsuko Tamasawa, Shiho Nakayama, Yuki Someya, Hidenori Ishida, Akio Kanazawa, Masahiko Gosho, Yoshio Fujitani, Hirotaka Watada

Published in: BMC Endocrine Disorders | Issue 1/2015

Abstract

Background

While poor sleep quality can worsen cardiovascular risk factors such as glucose and lipid profiles in patients with type 2 diabetes mellitus (T2DM), the relationship between sleep quality and atherosclerosis remains largely unknown. The aim of this study was to examine this relationship.

Methods

The study participants comprised 724 Japanese T2DM outpatients free of history of cardiovascular diseases. The relationships between sleep quality (assessed by the Pittsburgh Sleep Quality Index (PSQI)) and various clinical and laboratory parameters were investigated.

Results

The mean PSQI was 5.1 ± 3.0 (±SD). Patients were divided into three groups based on the total PSQI score; subjects with good sleep quality (n = 462), average sleep quality (n = 185), and poor sleep quality (n = 77). In the age/gender-adjusted model, patients with poor sleep quality tended to be obese, evening type and depressed. However, other lifestyles showed no significant trends. Alanine aminotransferase, fasting blood glucose, HbA1c, systolic blood pressure, urinary albumin excretion, and brachial-ankle pulse wave velocity (baPWV) tended to be higher in patients with poor sleep quality. High baPWV was the only parameter that correlated with poor sleep in a model adjusted for several other lifestyle factors.

Conclusions

Our study indicates that poor sleep quality in T2DM patients correlates with increased arterial wall stiffness, a marker of atherosclerosis and a risk factor for cardiovascular diseases.

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Title: Poor sleep quality is associated with increased arterial stiffness in Japanese patients with type 2 diabetes mellitus
Authors: Yusuke Osonoi
Tomoya Mita
Takeshi Osonoi
Miyoko Saito
Atsuko Tamasawa
Shiho Nakayama
Yuki Someya
Hidenori Ishida
Akio Kanazawa
Masahiko Gosho
Yoshio Fujitani
Hirotaka Watada
Publication date: 01-12-2015
Publisher: BioMed Central
Published in: BMC Endocrine Disorders / Issue 1/2015
Electronic ISSN: 1472-6823
DOI: https://doi.org/10.1186/s12902-015-0026-1

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Poor sleep quality is associated with increased arterial stiffness in Japanese patients with type 2 diabetes mellitus

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Methods

Results

Conclusions

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Abstract

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